Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex
Abstract Sensory systems are organized hierarchically, but feedback projections frequently disrupt this order. In the olfactory bulb (OB), cortical feedback projections numerically match sensory inputs. To unravel information carried by these two streams, we imaged the activity of olfactory sensory...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-47366-6 |
| _version_ | 1827277025933524992 |
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| author | Joseph D. Zak Gautam Reddy Vaibhav Konanur Venkatesh N. Murthy |
| author_facet | Joseph D. Zak Gautam Reddy Vaibhav Konanur Venkatesh N. Murthy |
| author_sort | Joseph D. Zak |
| collection | DOAJ |
| description | Abstract Sensory systems are organized hierarchically, but feedback projections frequently disrupt this order. In the olfactory bulb (OB), cortical feedback projections numerically match sensory inputs. To unravel information carried by these two streams, we imaged the activity of olfactory sensory neurons (OSNs) and cortical axons in the mouse OB using calcium indicators, multiphoton microscopy, and diverse olfactory stimuli. Here, we show that odorant mixtures of increasing complexity evoke progressively denser OSN activity, yet cortical feedback activity is of similar sparsity for all stimuli. Also, representations of complex mixtures are similar in OSNs but are decorrelated in cortical axons. While OSN responses to increasing odorant concentrations exhibit a sigmoidal relationship, cortical axonal responses are complex and nonmonotonic, which can be explained by a model with activity-dependent feedback inhibition in the cortex. Our study indicates that early-stage olfactory circuits have access to local feedforward signals and global, efficiently formatted information about odor scenes through cortical feedback. |
| first_indexed | 2024-04-24T07:14:02Z |
| format | Article |
| id | doaj.art-57ec30064d9d418cad7b1d3aca5d3bb8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-24T07:14:02Z |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-57ec30064d9d418cad7b1d3aca5d3bb82024-04-21T11:24:27ZengNature PortfolioNature Communications2041-17232024-04-0115111610.1038/s41467-024-47366-6Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortexJoseph D. Zak0Gautam Reddy1Vaibhav Konanur2Venkatesh N. Murthy3Department of Biological Sciences, University of Illinois ChicagoPhysics & Informatics Laboratories, NTT Research, Inc.Department of Biological Sciences, University of Illinois ChicagoCenter for Brain Science, Harvard UniversityAbstract Sensory systems are organized hierarchically, but feedback projections frequently disrupt this order. In the olfactory bulb (OB), cortical feedback projections numerically match sensory inputs. To unravel information carried by these two streams, we imaged the activity of olfactory sensory neurons (OSNs) and cortical axons in the mouse OB using calcium indicators, multiphoton microscopy, and diverse olfactory stimuli. Here, we show that odorant mixtures of increasing complexity evoke progressively denser OSN activity, yet cortical feedback activity is of similar sparsity for all stimuli. Also, representations of complex mixtures are similar in OSNs but are decorrelated in cortical axons. While OSN responses to increasing odorant concentrations exhibit a sigmoidal relationship, cortical axonal responses are complex and nonmonotonic, which can be explained by a model with activity-dependent feedback inhibition in the cortex. Our study indicates that early-stage olfactory circuits have access to local feedforward signals and global, efficiently formatted information about odor scenes through cortical feedback.https://doi.org/10.1038/s41467-024-47366-6 |
| spellingShingle | Joseph D. Zak Gautam Reddy Vaibhav Konanur Venkatesh N. Murthy Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex Nature Communications |
| title | Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex |
| title_full | Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex |
| title_fullStr | Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex |
| title_full_unstemmed | Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex |
| title_short | Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex |
| title_sort | distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex |
| url | https://doi.org/10.1038/s41467-024-47366-6 |
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