Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline
The aim of this review is to highlight the beneficial attributes of flavonoids, a diverse family of widely-distributed polyphenolic phytochemicals that have beneficial cell and tissue protective properties. Phytochemicals are widely distributed in plants, herbs and shrubs used in traditional complim...
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| Format: | Article |
| Language: | English |
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IMR Press
2022-10-01
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| Series: | Frontiers in Bioscience-Elite |
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| Online Access: | https://www.imrpress.com/journal/FBE/14/4/10.31083/j.fbe1404027 |
| _version_ | 1797975736469946368 |
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| author | James Melrose Margaret M. Smith |
| author_facet | James Melrose Margaret M. Smith |
| author_sort | James Melrose |
| collection | DOAJ |
| description | The aim of this review is to highlight the beneficial attributes of flavonoids, a diverse family of widely-distributed polyphenolic phytochemicals that have beneficial cell and tissue protective properties. Phytochemicals are widely distributed in plants, herbs and shrubs used in traditional complimentary medical formulations for centuries. The bioactive components that convey beneficial medicinal effects in these complex herbal preparations are now being identified using network pharmacology and molecular docking procedures that identify their molecular targets. Flavonoids have anti-oxidant, anti-inflammatory, antiviral, antibacterial and anti-cancer properties that have inspired the development of potent multifunctional derivatised flavonoids of improved efficacy. The antiviral properties of flavonoids and the emergence of the severe acute respiratory syndrome (SARS-CoV-2) pandemic has resulted in a resurgence of interest in phytochemicals in the search for efficacious compounds that can prevent viral infection or replication, with many promising plant compounds identified. Promising semi-synthetic flavonoid derivatives have also been developed that inhibit multiple pathological neurodegenerative processes; these offer considerable promise in the treatment of diseases of cognitive decline. Clinical trials are currently being undertaken to evaluate the efficacy of dietary supplements rich in flavonoids for the treatment of virally-mediated diseases. Such trials are expected to identify flavonoids with cell and tissue protective properties that can be harnessed in biomedical applications that may serve as supportive adjunctive procedures to conventional anti-viral drug therapies against diseases such as COVID-19. |
| first_indexed | 2024-04-11T04:40:09Z |
| format | Article |
| id | doaj.art-57ecb6f7194c41a2b5911bf799aa8b85 |
| institution | Directory Open Access Journal |
| issn | 1945-0494 |
| language | English |
| last_indexed | 2024-04-11T04:40:09Z |
| publishDate | 2022-10-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Elite |
| spelling | doaj.art-57ecb6f7194c41a2b5911bf799aa8b852022-12-28T07:10:02ZengIMR PressFrontiers in Bioscience-Elite1945-04942022-10-011442710.31083/j.fbe1404027S1945-0494(22)00079-0Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive DeclineJames Melrose0Margaret M. Smith1Raymond Purves Laboratory, Institute of Bone and Joint Research, Kolling Institute of Medical Research, Faculty of Health and Science, University of Sydney at Royal North Shore Hospital, St. Leonards, NSW 2065, AustraliaRaymond Purves Laboratory, Institute of Bone and Joint Research, Kolling Institute of Medical Research, Faculty of Health and Science, University of Sydney at Royal North Shore Hospital, St. Leonards, NSW 2065, AustraliaThe aim of this review is to highlight the beneficial attributes of flavonoids, a diverse family of widely-distributed polyphenolic phytochemicals that have beneficial cell and tissue protective properties. Phytochemicals are widely distributed in plants, herbs and shrubs used in traditional complimentary medical formulations for centuries. The bioactive components that convey beneficial medicinal effects in these complex herbal preparations are now being identified using network pharmacology and molecular docking procedures that identify their molecular targets. Flavonoids have anti-oxidant, anti-inflammatory, antiviral, antibacterial and anti-cancer properties that have inspired the development of potent multifunctional derivatised flavonoids of improved efficacy. The antiviral properties of flavonoids and the emergence of the severe acute respiratory syndrome (SARS-CoV-2) pandemic has resulted in a resurgence of interest in phytochemicals in the search for efficacious compounds that can prevent viral infection or replication, with many promising plant compounds identified. Promising semi-synthetic flavonoid derivatives have also been developed that inhibit multiple pathological neurodegenerative processes; these offer considerable promise in the treatment of diseases of cognitive decline. Clinical trials are currently being undertaken to evaluate the efficacy of dietary supplements rich in flavonoids for the treatment of virally-mediated diseases. Such trials are expected to identify flavonoids with cell and tissue protective properties that can be harnessed in biomedical applications that may serve as supportive adjunctive procedures to conventional anti-viral drug therapies against diseases such as COVID-19.https://www.imrpress.com/journal/FBE/14/4/10.31083/j.fbe1404027flavoneschalconesanti-viral phytochemicalssars-cov-2long covid diseaseanti-inflammatoryanti-oxidantneuroinflammationneuroprotectioncognition and memorynrf2alzheimer's diseaseardsparkinson's disease |
| spellingShingle | James Melrose Margaret M. Smith Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline Frontiers in Bioscience-Elite flavones chalcones anti-viral phytochemicals sars-cov-2 long covid disease anti-inflammatory anti-oxidant neuroinflammation neuroprotection cognition and memory nrf2 alzheimer's disease ards parkinson's disease |
| title | Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline |
| title_full | Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline |
| title_fullStr | Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline |
| title_full_unstemmed | Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline |
| title_short | Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline |
| title_sort | natural and semi synthetic flavonoid anti sars cov 2 agents for the treatment of long covid 19 disease and neurodegenerative disorders of cognitive decline |
| topic | flavones chalcones anti-viral phytochemicals sars-cov-2 long covid disease anti-inflammatory anti-oxidant neuroinflammation neuroprotection cognition and memory nrf2 alzheimer's disease ards parkinson's disease |
| url | https://www.imrpress.com/journal/FBE/14/4/10.31083/j.fbe1404027 |
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