Factors Influencing Microbiota in Modulating Vaccine Immune Response: A Long Way to Go
Vaccine immunogenicity still represents an unmet need in specific populations, such as people from developing countries and “edge populations”. Both intrinsic and extrinsic factors, such as the environment, age, and dietary habits, influence cellular and humoral immune responses. The human microbiot...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/11/10/1609 |
| _version_ | 1811153775440691200 |
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| author | Francesca Romana Ponziani Gaetano Coppola Pierluigi Rio Mario Caldarelli Raffaele Borriello Giovanni Gambassi Antonio Gasbarrini Rossella Cianci |
| author_facet | Francesca Romana Ponziani Gaetano Coppola Pierluigi Rio Mario Caldarelli Raffaele Borriello Giovanni Gambassi Antonio Gasbarrini Rossella Cianci |
| author_sort | Francesca Romana Ponziani |
| collection | DOAJ |
| description | Vaccine immunogenicity still represents an unmet need in specific populations, such as people from developing countries and “edge populations”. Both intrinsic and extrinsic factors, such as the environment, age, and dietary habits, influence cellular and humoral immune responses. The human microbiota represents a potential key to understanding how these factors impact the immune response to vaccination, with its modulation being a potential step to address vaccine immunogenicity. The aim of this narrative review is to explore the intricate interactions between the microbiota and the immune system in response to vaccines, highlighting the state of the art in gut microbiota modulation as a novel therapeutic approach to enhancing vaccine immunogenicity and laying the foundation for future, more solid data for its translation to the clinical practice. |
| first_indexed | 2024-03-10T20:49:51Z |
| format | Article |
| id | doaj.art-57ed603d3e0440bca83694ab992173c6 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T20:49:51Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-57ed603d3e0440bca83694ab992173c62023-11-19T18:25:19ZengMDPI AGVaccines2076-393X2023-10-011110160910.3390/vaccines11101609Factors Influencing Microbiota in Modulating Vaccine Immune Response: A Long Way to GoFrancesca Romana Ponziani0Gaetano Coppola1Pierluigi Rio2Mario Caldarelli3Raffaele Borriello4Giovanni Gambassi5Antonio Gasbarrini6Rossella Cianci7Department of Translational Medicine and Surgery, Catholic University, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Catholic University, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Catholic University, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Catholic University, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Catholic University, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Catholic University, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Catholic University, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Catholic University, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, ItalyVaccine immunogenicity still represents an unmet need in specific populations, such as people from developing countries and “edge populations”. Both intrinsic and extrinsic factors, such as the environment, age, and dietary habits, influence cellular and humoral immune responses. The human microbiota represents a potential key to understanding how these factors impact the immune response to vaccination, with its modulation being a potential step to address vaccine immunogenicity. The aim of this narrative review is to explore the intricate interactions between the microbiota and the immune system in response to vaccines, highlighting the state of the art in gut microbiota modulation as a novel therapeutic approach to enhancing vaccine immunogenicity and laying the foundation for future, more solid data for its translation to the clinical practice.https://www.mdpi.com/2076-393X/11/10/1609vaccine immunogenicitymicrobiotaimmune system |
| spellingShingle | Francesca Romana Ponziani Gaetano Coppola Pierluigi Rio Mario Caldarelli Raffaele Borriello Giovanni Gambassi Antonio Gasbarrini Rossella Cianci Factors Influencing Microbiota in Modulating Vaccine Immune Response: A Long Way to Go Vaccines vaccine immunogenicity microbiota immune system |
| title | Factors Influencing Microbiota in Modulating Vaccine Immune Response: A Long Way to Go |
| title_full | Factors Influencing Microbiota in Modulating Vaccine Immune Response: A Long Way to Go |
| title_fullStr | Factors Influencing Microbiota in Modulating Vaccine Immune Response: A Long Way to Go |
| title_full_unstemmed | Factors Influencing Microbiota in Modulating Vaccine Immune Response: A Long Way to Go |
| title_short | Factors Influencing Microbiota in Modulating Vaccine Immune Response: A Long Way to Go |
| title_sort | factors influencing microbiota in modulating vaccine immune response a long way to go |
| topic | vaccine immunogenicity microbiota immune system |
| url | https://www.mdpi.com/2076-393X/11/10/1609 |
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