MDCT-Based Finite Element Analyses: Are Measurements at the Lumbar Spine Associated with the Biomechanical Strength of Functional Spinal Units of Incidental Osteoporotic Fractures along the Thoracolumbar Spine?
Assessment of osteoporosis-associated fracture risk during clinical routine is based on the evaluation of clinical risk factors and T-scores, as derived from measurements of areal bone mineral density (aBMD). However, these parameters are limited in their ability to identify patients at high fractur...
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MDPI AG
2021-03-01
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| Online Access: | https://www.mdpi.com/2075-4418/11/3/455 |
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| author | Nico Sollmann Nithin Manohar Rayudu Long Yu Yeung Anjany Sekuboyina Egon Burian Michael Dieckmeyer Maximilian T. Löffler Benedikt J. Schwaiger Alexandra S. Gersing Jan S. Kirschke Thomas Baum Karupppasamy Subburaj |
| author_facet | Nico Sollmann Nithin Manohar Rayudu Long Yu Yeung Anjany Sekuboyina Egon Burian Michael Dieckmeyer Maximilian T. Löffler Benedikt J. Schwaiger Alexandra S. Gersing Jan S. Kirschke Thomas Baum Karupppasamy Subburaj |
| author_sort | Nico Sollmann |
| collection | DOAJ |
| description | Assessment of osteoporosis-associated fracture risk during clinical routine is based on the evaluation of clinical risk factors and T-scores, as derived from measurements of areal bone mineral density (aBMD). However, these parameters are limited in their ability to identify patients at high fracture risk. Finite element models (FEMs) have shown to improve bone strength prediction beyond aBMD. This study aims to investigate whether FEM measurements at the lumbar spine can predict the biomechanical strength of functional spinal units (FSUs) with incidental osteoporotic vertebral fractures (VFs) along the thoracolumbar spine. Multi-detector computed tomography (MDCT) data of 11 patients (5 females and 6 males, median age: 67 years) who underwent MDCT twice (median interval between baseline and follow-up MDCT: 18 months) and sustained an incidental osteoporotic VF between baseline and follow-up scanning were used. Based on baseline MDCT data, two FSUs consisting of vertebral bodies and intervertebral discs (IVDs) were modeled: one standardly capturing L1-IVD–L2-IVD–L3 (FSU_L1–L3) and one modeling the incidentally fractured vertebral body at the center of the FSU (FSU_F). Furthermore, volumetric BMD (vBMD) derived from MDCT, FEM-based displacement, and FEM-based load of the single vertebrae L1 to L3 were determined. Statistically significant correlations (adjusted for a BMD ratio of fracture/L1–L3 segments) were revealed between the FSU_F and mean load of L1 to L3 (r = 0.814, <i>p</i> = 0.004) and the mean vBMD of L1 to L3 (r = 0.745, <i>p</i> = 0.013), whereas there was no statistically significant association between the FSU_F and FSU_L1–L3 or between FSU_F and the mean displacement of L1 to L3 (<i>p</i> > 0.05). In conclusion, FEM measurements of single vertebrae at the lumbar spine may be able to predict the biomechanical strength of incidentally fractured vertebral segments along the thoracolumbar spine, while FSUs seem to predict only segment-specific fracture risk. |
| first_indexed | 2024-03-09T05:10:56Z |
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| id | doaj.art-57f0c26cdf4f499497fcb9a342f2a191 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T05:10:56Z |
| publishDate | 2021-03-01 |
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| spelling | doaj.art-57f0c26cdf4f499497fcb9a342f2a1912023-12-03T12:49:48ZengMDPI AGDiagnostics2075-44182021-03-0111345510.3390/diagnostics11030455MDCT-Based Finite Element Analyses: Are Measurements at the Lumbar Spine Associated with the Biomechanical Strength of Functional Spinal Units of Incidental Osteoporotic Fractures along the Thoracolumbar Spine?Nico Sollmann0Nithin Manohar Rayudu1Long Yu Yeung2Anjany Sekuboyina3Egon Burian4Michael Dieckmeyer5Maximilian T. Löffler6Benedikt J. Schwaiger7Alexandra S. Gersing8Jan S. Kirschke9Thomas Baum10Karupppasamy Subburaj11Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyEngineering Product Development (EPD) Pillar, Singapore University of Technology and Design (SUTD), Singapore 487372, SingaporeEngineering Product Development (EPD) Pillar, Singapore University of Technology and Design (SUTD), Singapore 487372, SingaporeDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyInstitute of Neuroradiology, University Hospital, LMU Munich, Marchioninistrasse 15, 81377 Munich, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, GermanyEngineering Product Development (EPD) Pillar, Singapore University of Technology and Design (SUTD), Singapore 487372, SingaporeAssessment of osteoporosis-associated fracture risk during clinical routine is based on the evaluation of clinical risk factors and T-scores, as derived from measurements of areal bone mineral density (aBMD). However, these parameters are limited in their ability to identify patients at high fracture risk. Finite element models (FEMs) have shown to improve bone strength prediction beyond aBMD. This study aims to investigate whether FEM measurements at the lumbar spine can predict the biomechanical strength of functional spinal units (FSUs) with incidental osteoporotic vertebral fractures (VFs) along the thoracolumbar spine. Multi-detector computed tomography (MDCT) data of 11 patients (5 females and 6 males, median age: 67 years) who underwent MDCT twice (median interval between baseline and follow-up MDCT: 18 months) and sustained an incidental osteoporotic VF between baseline and follow-up scanning were used. Based on baseline MDCT data, two FSUs consisting of vertebral bodies and intervertebral discs (IVDs) were modeled: one standardly capturing L1-IVD–L2-IVD–L3 (FSU_L1–L3) and one modeling the incidentally fractured vertebral body at the center of the FSU (FSU_F). Furthermore, volumetric BMD (vBMD) derived from MDCT, FEM-based displacement, and FEM-based load of the single vertebrae L1 to L3 were determined. Statistically significant correlations (adjusted for a BMD ratio of fracture/L1–L3 segments) were revealed between the FSU_F and mean load of L1 to L3 (r = 0.814, <i>p</i> = 0.004) and the mean vBMD of L1 to L3 (r = 0.745, <i>p</i> = 0.013), whereas there was no statistically significant association between the FSU_F and FSU_L1–L3 or between FSU_F and the mean displacement of L1 to L3 (<i>p</i> > 0.05). In conclusion, FEM measurements of single vertebrae at the lumbar spine may be able to predict the biomechanical strength of incidentally fractured vertebral segments along the thoracolumbar spine, while FSUs seem to predict only segment-specific fracture risk.https://www.mdpi.com/2075-4418/11/3/455bone mineral densityfinite element analysisfunctional spinal unitincidental fracturemulti-detector computed tomographyosteoporosis |
| spellingShingle | Nico Sollmann Nithin Manohar Rayudu Long Yu Yeung Anjany Sekuboyina Egon Burian Michael Dieckmeyer Maximilian T. Löffler Benedikt J. Schwaiger Alexandra S. Gersing Jan S. Kirschke Thomas Baum Karupppasamy Subburaj MDCT-Based Finite Element Analyses: Are Measurements at the Lumbar Spine Associated with the Biomechanical Strength of Functional Spinal Units of Incidental Osteoporotic Fractures along the Thoracolumbar Spine? Diagnostics bone mineral density finite element analysis functional spinal unit incidental fracture multi-detector computed tomography osteoporosis |
| title | MDCT-Based Finite Element Analyses: Are Measurements at the Lumbar Spine Associated with the Biomechanical Strength of Functional Spinal Units of Incidental Osteoporotic Fractures along the Thoracolumbar Spine? |
| title_full | MDCT-Based Finite Element Analyses: Are Measurements at the Lumbar Spine Associated with the Biomechanical Strength of Functional Spinal Units of Incidental Osteoporotic Fractures along the Thoracolumbar Spine? |
| title_fullStr | MDCT-Based Finite Element Analyses: Are Measurements at the Lumbar Spine Associated with the Biomechanical Strength of Functional Spinal Units of Incidental Osteoporotic Fractures along the Thoracolumbar Spine? |
| title_full_unstemmed | MDCT-Based Finite Element Analyses: Are Measurements at the Lumbar Spine Associated with the Biomechanical Strength of Functional Spinal Units of Incidental Osteoporotic Fractures along the Thoracolumbar Spine? |
| title_short | MDCT-Based Finite Element Analyses: Are Measurements at the Lumbar Spine Associated with the Biomechanical Strength of Functional Spinal Units of Incidental Osteoporotic Fractures along the Thoracolumbar Spine? |
| title_sort | mdct based finite element analyses are measurements at the lumbar spine associated with the biomechanical strength of functional spinal units of incidental osteoporotic fractures along the thoracolumbar spine |
| topic | bone mineral density finite element analysis functional spinal unit incidental fracture multi-detector computed tomography osteoporosis |
| url | https://www.mdpi.com/2075-4418/11/3/455 |
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