Effects of sacral nerve stimulation on postpartum urinary retention-related changes in rat bladder
Objective: To examine the effect of sacral nerve stimulation (SNS) on the urodynamic function and molecular structure of bladders in rats following acute urinary retention (AUR) after parturition. Material and methods: Thirty primiparous rats were divided into three groups: postpartum, postpartum+AU...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-12-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455915002272 |
| _version_ | 1818304288693157888 |
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| author | Shuenn-Dhy Chang Yi-hao Lin Ching-Chung Liang Tse-Ching Chen |
| author_facet | Shuenn-Dhy Chang Yi-hao Lin Ching-Chung Liang Tse-Ching Chen |
| author_sort | Shuenn-Dhy Chang |
| collection | DOAJ |
| description | Objective: To examine the effect of sacral nerve stimulation (SNS) on the urodynamic function and molecular structure of bladders in rats following acute urinary retention (AUR) after parturition.
Material and methods: Thirty primiparous rats were divided into three groups: postpartum, postpartum+AUR, and postpartum+AUR+SNS. AUR was achieved by clamping the distal urethra of a rat for 60 minutes. The postpartum+AUR+SNS group received electrical stimulation 60 minutes daily for 3 days after AUR. In addition to cystometric studies and external urethral sphincter electromyography, the expression of caveolins and nerve growth factor (NGF) and caveolae number in bladder muscle were analyzed.
Results: The postpartum+AUR group has significantly greater residual volume than the postpartum group, but the residual volume decreased significantly after SNS treatment. The postpartum+AUR group had significantly lower peak voiding pressure, a longer bursting period and lower amplitude of electromyograms of external urethral sphincter activity than the postpartum and postpartum+AUR+SNS groups. The postpartum+AUR rats had higher NGF expression, lower caveolin-1 expression, and fewer caveolae in bladder muscle compared with the postpartum rats. Conversely, the caveolin-1 expression and caveolae number increased, and the NGF expression decreased after SNS treatment.
Conclusion: Bladder dysfunction after parturition in a rat model caused by AUR may be restored to the non-AUR structural and functional level after SNS treatment. |
| first_indexed | 2024-12-13T06:08:19Z |
| format | Article |
| id | doaj.art-57f0dbd634f049338efaa8367f5fdc91 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-13T06:08:19Z |
| publishDate | 2015-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-57f0dbd634f049338efaa8367f5fdc912022-12-21T23:57:10ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592015-12-0154667167710.1016/j.tjog.2015.10.001Effects of sacral nerve stimulation on postpartum urinary retention-related changes in rat bladderShuenn-Dhy Chang0Yi-hao Lin1Ching-Chung Liang2Tse-Ching Chen3Division of Urogynecology, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, TaiwanDivision of Urogynecology, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, TaiwanDivision of Urogynecology, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanObjective: To examine the effect of sacral nerve stimulation (SNS) on the urodynamic function and molecular structure of bladders in rats following acute urinary retention (AUR) after parturition. Material and methods: Thirty primiparous rats were divided into three groups: postpartum, postpartum+AUR, and postpartum+AUR+SNS. AUR was achieved by clamping the distal urethra of a rat for 60 minutes. The postpartum+AUR+SNS group received electrical stimulation 60 minutes daily for 3 days after AUR. In addition to cystometric studies and external urethral sphincter electromyography, the expression of caveolins and nerve growth factor (NGF) and caveolae number in bladder muscle were analyzed. Results: The postpartum+AUR group has significantly greater residual volume than the postpartum group, but the residual volume decreased significantly after SNS treatment. The postpartum+AUR group had significantly lower peak voiding pressure, a longer bursting period and lower amplitude of electromyograms of external urethral sphincter activity than the postpartum and postpartum+AUR+SNS groups. The postpartum+AUR rats had higher NGF expression, lower caveolin-1 expression, and fewer caveolae in bladder muscle compared with the postpartum rats. Conversely, the caveolin-1 expression and caveolae number increased, and the NGF expression decreased after SNS treatment. Conclusion: Bladder dysfunction after parturition in a rat model caused by AUR may be restored to the non-AUR structural and functional level after SNS treatment.http://www.sciencedirect.com/science/article/pii/S1028455915002272caveolincystometric studynerve growth factorsacral nerve stimulationurinary retention |
| spellingShingle | Shuenn-Dhy Chang Yi-hao Lin Ching-Chung Liang Tse-Ching Chen Effects of sacral nerve stimulation on postpartum urinary retention-related changes in rat bladder Taiwanese Journal of Obstetrics & Gynecology caveolin cystometric study nerve growth factor sacral nerve stimulation urinary retention |
| title | Effects of sacral nerve stimulation on postpartum urinary retention-related changes in rat bladder |
| title_full | Effects of sacral nerve stimulation on postpartum urinary retention-related changes in rat bladder |
| title_fullStr | Effects of sacral nerve stimulation on postpartum urinary retention-related changes in rat bladder |
| title_full_unstemmed | Effects of sacral nerve stimulation on postpartum urinary retention-related changes in rat bladder |
| title_short | Effects of sacral nerve stimulation on postpartum urinary retention-related changes in rat bladder |
| title_sort | effects of sacral nerve stimulation on postpartum urinary retention related changes in rat bladder |
| topic | caveolin cystometric study nerve growth factor sacral nerve stimulation urinary retention |
| url | http://www.sciencedirect.com/science/article/pii/S1028455915002272 |
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