The Onco-Nephrology Field: The Role of Personalized Chemotherapy to Prevent Kidney Damage
In recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena af...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/8/2254 |
| _version_ | 1797606060009193472 |
|---|---|
| author | Annalisa Noce Giulia Marrone Manuela Di Lauro Anna Paola Mitterhofer Maria Josè Ceravolo Nicola Di Daniele Guglielmo Manenti Antonino De Lorenzo |
| author_facet | Annalisa Noce Giulia Marrone Manuela Di Lauro Anna Paola Mitterhofer Maria Josè Ceravolo Nicola Di Daniele Guglielmo Manenti Antonino De Lorenzo |
| author_sort | Annalisa Noce |
| collection | DOAJ |
| description | In recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena affecting the excretory tract or by neoplastic dissemination) or by chemotherapy, as it is potentially nephrotoxic. Kidney damage can manifest as acute kidney injury or represent a worsening of pre-existing chronic kidney disease. In cancer patients, physicians should try to set preventive strategies to safeguard the renal function, avoiding the concomitant use of nephrotoxic drugs, personalizing the dose of chemotherapy according to the glomerular filtration rate (GFR) and using an appropriate hydration therapy in combination with nephroprotective compounds. To prevent renal dysfunction, a new possible tool useful in the field of onco-nephrology would be the development of a personalized algorithm for the patient based on body composition parameters, gender, nutritional status, GFR and genetic polymorphisms. |
| first_indexed | 2024-03-11T05:10:00Z |
| format | Article |
| id | doaj.art-57f1f4511f4140ab9bdb78fe6afd4ee1 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T05:10:00Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-57f1f4511f4140ab9bdb78fe6afd4ee12023-11-17T18:38:26ZengMDPI AGCancers2072-66942023-04-01158225410.3390/cancers15082254The Onco-Nephrology Field: The Role of Personalized Chemotherapy to Prevent Kidney DamageAnnalisa Noce0Giulia Marrone1Manuela Di Lauro2Anna Paola Mitterhofer3Maria Josè Ceravolo4Nicola Di Daniele5Guglielmo Manenti6Antonino De Lorenzo7Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, ItalyNephrology and Dialysis Unit, Policlinico Tor Vergata, 00133 Rome, ItalyDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Diagnostic Imaging and Interventional Radiology, University of Rome Tor Vergata, 00133 Rome, ItalySection of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyIn recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena affecting the excretory tract or by neoplastic dissemination) or by chemotherapy, as it is potentially nephrotoxic. Kidney damage can manifest as acute kidney injury or represent a worsening of pre-existing chronic kidney disease. In cancer patients, physicians should try to set preventive strategies to safeguard the renal function, avoiding the concomitant use of nephrotoxic drugs, personalizing the dose of chemotherapy according to the glomerular filtration rate (GFR) and using an appropriate hydration therapy in combination with nephroprotective compounds. To prevent renal dysfunction, a new possible tool useful in the field of onco-nephrology would be the development of a personalized algorithm for the patient based on body composition parameters, gender, nutritional status, GFR and genetic polymorphisms.https://www.mdpi.com/2072-6694/15/8/2254acute kidney injurychemotherapeutic drugschronic kidney diseaserenal insufficiencypredictive algorithm |
| spellingShingle | Annalisa Noce Giulia Marrone Manuela Di Lauro Anna Paola Mitterhofer Maria Josè Ceravolo Nicola Di Daniele Guglielmo Manenti Antonino De Lorenzo The Onco-Nephrology Field: The Role of Personalized Chemotherapy to Prevent Kidney Damage Cancers acute kidney injury chemotherapeutic drugs chronic kidney disease renal insufficiency predictive algorithm |
| title | The Onco-Nephrology Field: The Role of Personalized Chemotherapy to Prevent Kidney Damage |
| title_full | The Onco-Nephrology Field: The Role of Personalized Chemotherapy to Prevent Kidney Damage |
| title_fullStr | The Onco-Nephrology Field: The Role of Personalized Chemotherapy to Prevent Kidney Damage |
| title_full_unstemmed | The Onco-Nephrology Field: The Role of Personalized Chemotherapy to Prevent Kidney Damage |
| title_short | The Onco-Nephrology Field: The Role of Personalized Chemotherapy to Prevent Kidney Damage |
| title_sort | onco nephrology field the role of personalized chemotherapy to prevent kidney damage |
| topic | acute kidney injury chemotherapeutic drugs chronic kidney disease renal insufficiency predictive algorithm |
| url | https://www.mdpi.com/2072-6694/15/8/2254 |
| work_keys_str_mv | AT annalisanoce theonconephrologyfieldtheroleofpersonalizedchemotherapytopreventkidneydamage AT giuliamarrone theonconephrologyfieldtheroleofpersonalizedchemotherapytopreventkidneydamage AT manueladilauro theonconephrologyfieldtheroleofpersonalizedchemotherapytopreventkidneydamage AT annapaolamitterhofer theonconephrologyfieldtheroleofpersonalizedchemotherapytopreventkidneydamage AT mariajoseceravolo theonconephrologyfieldtheroleofpersonalizedchemotherapytopreventkidneydamage AT nicoladidaniele theonconephrologyfieldtheroleofpersonalizedchemotherapytopreventkidneydamage AT guglielmomanenti theonconephrologyfieldtheroleofpersonalizedchemotherapytopreventkidneydamage AT antoninodelorenzo theonconephrologyfieldtheroleofpersonalizedchemotherapytopreventkidneydamage AT annalisanoce onconephrologyfieldtheroleofpersonalizedchemotherapytopreventkidneydamage AT giuliamarrone onconephrologyfieldtheroleofpersonalizedchemotherapytopreventkidneydamage AT manueladilauro onconephrologyfieldtheroleofpersonalizedchemotherapytopreventkidneydamage AT annapaolamitterhofer onconephrologyfieldtheroleofpersonalizedchemotherapytopreventkidneydamage AT mariajoseceravolo onconephrologyfieldtheroleofpersonalizedchemotherapytopreventkidneydamage AT nicoladidaniele onconephrologyfieldtheroleofpersonalizedchemotherapytopreventkidneydamage AT guglielmomanenti onconephrologyfieldtheroleofpersonalizedchemotherapytopreventkidneydamage AT antoninodelorenzo onconephrologyfieldtheroleofpersonalizedchemotherapytopreventkidneydamage |