Radiotherapy-induced cell death activates paracrine HMGB1-TLR2 signaling and accelerates pancreatic carcinoma metastasis

Radiotherapy-induced cell death activates paracrine HMGB1-TLR2 signaling and accelerates pancreatic carcinoma metastasis

Abstract Background Dying cells after irradiation could promote the repopulation of surviving cancer cells leading to tumor recurrence. We aim to define the role of dying cells in promoting pancreatic cancer cells metastasis following radiotherapy. Methods Using the transwell system as the in vitro...

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Bibliographic Details
Main Authors: Xuelian Chen, Lirong Zhang, Yujie Jiang, Lian Song, Yanfang Liu, Fang Cheng, Xin Fan, Xiongfeng Cao, Aihua Gong, Dongqing Wang, Haitao Zhu
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pancreatic carcinoma
HMGB1
Metastasis
Radiotherapy
Online Access:http://link.springer.com/article/10.1186/s13046-018-0726-2

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