Dopamine Is a Siderophore-Like Iron Chelator That Promotes <italic toggle="yes">Salmonella enterica</italic> Serovar Typhimurium Virulence in Mice

Dopamine Is a Siderophore-Like Iron Chelator That Promotes <italic toggle="yes">Salmonella enterica</italic> Serovar Typhimurium Virulence in Mice

ABSTRACT We have recently shown that the catecholamine dopamine regulates cellular iron homeostasis in macrophages. As iron is an essential nutrient for microbes, and intracellular iron availability affects the growth of intracellular bacteria, we studied whether dopamine administration impacts the...

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Bibliographic Details
Main Authors: Stefanie Dichtl, Egon Demetz, David Haschka, Piotr Tymoszuk, Verena Petzer, Manfred Nairz, Markus Seifert, Alexander Hoffmann, Natascha Brigo, Reinhard Würzner, Igor Theurl, Joyce E. Karlinsey, Ferric C. Fang, Günter Weiss
Format: Article
Language:English
Published: American Society for Microbiology 2019-02-01
Series:mBio
Subjects:
Salmonella Typhimurium
catecholamine
dopamine
iron
qseC
sepsis
Online Access:https://journals.asm.org/doi/10.1128/mBio.02624-18

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