Preparation, characterization, and pharmacodynamics of insulin-loaded fumaryl diketopiperazine microparticle dry powder inhalation
Purpose: With the increase of population aging and the proportion of overweight and obese, a growing number of people are suffering from diabetes. Insulin (INS) as the most widely used hypoglycemic agent was always chosen as the most effective treatment method of diabetes. In this study, fumaryl dik...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2019.1631408 |
| _version_ | 1828853902418640896 |
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| author | Yun Xia Yipeng Su Qiyue Wang Chen Yang Baoqiang Tang Yue Zhang Jiasheng Tu Yan Shen |
| author_facet | Yun Xia Yipeng Su Qiyue Wang Chen Yang Baoqiang Tang Yue Zhang Jiasheng Tu Yan Shen |
| author_sort | Yun Xia |
| collection | DOAJ |
| description | Purpose: With the increase of population aging and the proportion of overweight and obese, a growing number of people are suffering from diabetes. Insulin (INS) as the most widely used hypoglycemic agent was always chosen as the most effective treatment method of diabetes. In this study, fumaryl diketopiperazine (FDKP) was used as a carrier for the pulmonary delivery of insulin. Patients and methods: The INS-loaded FDKP microspheres (INS@FDKP-MPs) were prepared by spray drying and physicochemical properties (drug loading, particle size, flowability, moisture content, morphology, and crystalline state) were further investigated. Pharmacodynamics was investigated on diabetic model rats administrated by intratracheal insufflation. Results: The INS-loaded FDKP microspheres show satisfied flowability and in vitro deposition with FPF 50.2% and MMAD 3.45 ± 0.13 μm, and the blood glucose level was significantly decreased. Moreover, no inflammatory reaction was observed during the safety study. Conclusion: To sum up, the aim was to develop a non-injection system for insulin, INS@FDKP-MPs powder inhalation with high dose, low toxicity, and good lung deposition inhalation could rapidly decrease the blood glucose level without immune stimulation, which shows remarkably potential on diabetes treatment by pulmonary delivery route. |
| first_indexed | 2024-12-13T00:23:24Z |
| format | Article |
| id | doaj.art-57f7fac78be043a8929053c75c70c8e9 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-13T00:23:24Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-57f7fac78be043a8929053c75c70c8e92022-12-22T00:05:29ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642019-01-0126165066010.1080/10717544.2019.16314081631408Preparation, characterization, and pharmacodynamics of insulin-loaded fumaryl diketopiperazine microparticle dry powder inhalationYun Xia0Yipeng Su1Qiyue Wang2Chen Yang3Baoqiang Tang4Yue Zhang5Jiasheng Tu6Yan Shen7China Pharmaceutical UniversityChina Pharmaceutical UniversityChina Pharmaceutical UniversityChina Pharmaceutical UniversityChina Pharmaceutical UniversityChina Pharmaceutical UniversityChina Pharmaceutical UniversityChina Pharmaceutical UniversityPurpose: With the increase of population aging and the proportion of overweight and obese, a growing number of people are suffering from diabetes. Insulin (INS) as the most widely used hypoglycemic agent was always chosen as the most effective treatment method of diabetes. In this study, fumaryl diketopiperazine (FDKP) was used as a carrier for the pulmonary delivery of insulin. Patients and methods: The INS-loaded FDKP microspheres (INS@FDKP-MPs) were prepared by spray drying and physicochemical properties (drug loading, particle size, flowability, moisture content, morphology, and crystalline state) were further investigated. Pharmacodynamics was investigated on diabetic model rats administrated by intratracheal insufflation. Results: The INS-loaded FDKP microspheres show satisfied flowability and in vitro deposition with FPF 50.2% and MMAD 3.45 ± 0.13 μm, and the blood glucose level was significantly decreased. Moreover, no inflammatory reaction was observed during the safety study. Conclusion: To sum up, the aim was to develop a non-injection system for insulin, INS@FDKP-MPs powder inhalation with high dose, low toxicity, and good lung deposition inhalation could rapidly decrease the blood glucose level without immune stimulation, which shows remarkably potential on diabetes treatment by pulmonary delivery route.http://dx.doi.org/10.1080/10717544.2019.1631408insulinfdkpdiabeticinhalationpharmacodynamic |
| spellingShingle | Yun Xia Yipeng Su Qiyue Wang Chen Yang Baoqiang Tang Yue Zhang Jiasheng Tu Yan Shen Preparation, characterization, and pharmacodynamics of insulin-loaded fumaryl diketopiperazine microparticle dry powder inhalation Drug Delivery insulin fdkp diabetic inhalation pharmacodynamic |
| title | Preparation, characterization, and pharmacodynamics of insulin-loaded fumaryl diketopiperazine microparticle dry powder inhalation |
| title_full | Preparation, characterization, and pharmacodynamics of insulin-loaded fumaryl diketopiperazine microparticle dry powder inhalation |
| title_fullStr | Preparation, characterization, and pharmacodynamics of insulin-loaded fumaryl diketopiperazine microparticle dry powder inhalation |
| title_full_unstemmed | Preparation, characterization, and pharmacodynamics of insulin-loaded fumaryl diketopiperazine microparticle dry powder inhalation |
| title_short | Preparation, characterization, and pharmacodynamics of insulin-loaded fumaryl diketopiperazine microparticle dry powder inhalation |
| title_sort | preparation characterization and pharmacodynamics of insulin loaded fumaryl diketopiperazine microparticle dry powder inhalation |
| topic | insulin fdkp diabetic inhalation pharmacodynamic |
| url | http://dx.doi.org/10.1080/10717544.2019.1631408 |
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