Oral melanocytic nevi: Report of two cases with immunohistochemical elaboration of their probable origin and maturation
Oral melanocytic nevi are localized developmental tissue malformations of nevus cells in the oral mucosa. Relatively rare in occurrence compared to their dermal counterparts, considerable debate exists in the literature related to their origin, development and maturation, and their relationship to o...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Indian Journal of Dermatopathology and Diagnostic Dermatology |
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| Online Access: | http://www.ijdpdd.com/article.asp?issn=2349-6029;year=2015;volume=2;issue=2;spage=29;epage=33;aulast=Dutta |
| _version_ | 1828760179481509888 |
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| author | Dipti Dutta Venkatesh V Kamath Komali Rajkumar |
| author_facet | Dipti Dutta Venkatesh V Kamath Komali Rajkumar |
| author_sort | Dipti Dutta |
| collection | DOAJ |
| description | Oral melanocytic nevi are localized developmental tissue malformations of nevus cells in the oral mucosa. Relatively rare in occurrence compared to their dermal counterparts, considerable debate exists in the literature related to their origin, development and maturation, and their relationship to oral melanocytes.We report two cases of oral melanocytic nevi with classical clinical presentation. The histopathology was consistent with the known patterns of oral melanocytic nevi. Special stains such as Masson Fontana, further substantiated the observation. S-100 and HMB-45 were applied to immunohistochemically elaborate the cell population. Interestingly two distinct cell populations were detected in the lesions. "Type A" cells in the center of the lesion were S-100 positive, indicating a neural origin and immaturity in development, while peripheral "type B" cells stained positive with HMB-45, indicating melanocytic origin and mature development. |
| first_indexed | 2024-12-11T01:09:42Z |
| format | Article |
| id | doaj.art-57f8342b240f4563ae0120300c1bfc3b |
| institution | Directory Open Access Journal |
| issn | 2349-6029 2349-6029 |
| language | English |
| last_indexed | 2024-12-11T01:09:42Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatopathology and Diagnostic Dermatology |
| spelling | doaj.art-57f8342b240f4563ae0120300c1bfc3b2022-12-22T01:26:05ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatopathology and Diagnostic Dermatology2349-60292349-60292015-01-0122293310.4103/2349-6029.173413Oral melanocytic nevi: Report of two cases with immunohistochemical elaboration of their probable origin and maturationDipti DuttaVenkatesh V KamathKomali RajkumarOral melanocytic nevi are localized developmental tissue malformations of nevus cells in the oral mucosa. Relatively rare in occurrence compared to their dermal counterparts, considerable debate exists in the literature related to their origin, development and maturation, and their relationship to oral melanocytes.We report two cases of oral melanocytic nevi with classical clinical presentation. The histopathology was consistent with the known patterns of oral melanocytic nevi. Special stains such as Masson Fontana, further substantiated the observation. S-100 and HMB-45 were applied to immunohistochemically elaborate the cell population. Interestingly two distinct cell populations were detected in the lesions. "Type A" cells in the center of the lesion were S-100 positive, indicating a neural origin and immaturity in development, while peripheral "type B" cells stained positive with HMB-45, indicating melanocytic origin and mature development.http://www.ijdpdd.com/article.asp?issn=2349-6029;year=2015;volume=2;issue=2;spage=29;epage=33;aulast=DuttaHMB-45immunohistochemistryoral melanocytic neviS-100 |
| spellingShingle | Dipti Dutta Venkatesh V Kamath Komali Rajkumar Oral melanocytic nevi: Report of two cases with immunohistochemical elaboration of their probable origin and maturation Indian Journal of Dermatopathology and Diagnostic Dermatology HMB-45 immunohistochemistry oral melanocytic nevi S-100 |
| title | Oral melanocytic nevi: Report of two cases with immunohistochemical elaboration of their probable origin and maturation |
| title_full | Oral melanocytic nevi: Report of two cases with immunohistochemical elaboration of their probable origin and maturation |
| title_fullStr | Oral melanocytic nevi: Report of two cases with immunohistochemical elaboration of their probable origin and maturation |
| title_full_unstemmed | Oral melanocytic nevi: Report of two cases with immunohistochemical elaboration of their probable origin and maturation |
| title_short | Oral melanocytic nevi: Report of two cases with immunohistochemical elaboration of their probable origin and maturation |
| title_sort | oral melanocytic nevi report of two cases with immunohistochemical elaboration of their probable origin and maturation |
| topic | HMB-45 immunohistochemistry oral melanocytic nevi S-100 |
| url | http://www.ijdpdd.com/article.asp?issn=2349-6029;year=2015;volume=2;issue=2;spage=29;epage=33;aulast=Dutta |
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