The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis
Mechanical factors play critical roles in the pathogenesis of joint disorders like osteoarthritis (OA), a prevalent progressive degenerative joint disease that causes debilitating pain. Chondrocytes in the cartilage are responsible for extracellular matrix (ECM) turnover, and mechanical stimuli heav...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-05-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.885224/full |
| _version_ | 1828795488376193024 |
|---|---|
| author | Winni Gao Hamza Hasan Devon E. Anderson Devon E. Anderson Whasil Lee Whasil Lee Whasil Lee Whasil Lee |
| author_facet | Winni Gao Hamza Hasan Devon E. Anderson Devon E. Anderson Whasil Lee Whasil Lee Whasil Lee Whasil Lee |
| author_sort | Winni Gao |
| collection | DOAJ |
| description | Mechanical factors play critical roles in the pathogenesis of joint disorders like osteoarthritis (OA), a prevalent progressive degenerative joint disease that causes debilitating pain. Chondrocytes in the cartilage are responsible for extracellular matrix (ECM) turnover, and mechanical stimuli heavily influence cartilage maintenance, degeneration, and regeneration via mechanotransduction of chondrocytes. Thus, understanding the disease-associated mechanotransduction mechanisms can shed light on developing effective therapeutic strategies for OA through targeting mechanotransducers to halt progressive cartilage degeneration. Mechanosensitive Ca2+-permeating channels are robustly expressed in primary articular chondrocytes and trigger force-dependent cartilage remodeling and injury responses. This review discusses the current understanding of the roles of Piezo1, Piezo2, and TRPV4 mechanosensitive ion channels in cartilage health and disease with a highlight on the potential mechanotheraputic strategies to target these channels and prevent cartilage degeneration associated with OA. |
| first_indexed | 2024-12-12T04:06:02Z |
| format | Article |
| id | doaj.art-57fe20ee6d95468e97d72a6df018270f |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T04:06:02Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-57fe20ee6d95468e97d72a6df018270f2022-12-22T00:38:47ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-05-011010.3389/fcell.2022.885224885224The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for OsteoarthritisWinni Gao0Hamza Hasan1Devon E. Anderson2Devon E. Anderson3Whasil Lee4Whasil Lee5Whasil Lee6Whasil Lee7Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, United StatesDepartment of Biomedical Engineering, University of Rochester, Rochester, NY, United StatesDepartment of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY, United StatesCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United StatesDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, United StatesDepartment of Biomedical Engineering, University of Rochester, Rochester, NY, United StatesDepartment of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY, United StatesCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United StatesMechanical factors play critical roles in the pathogenesis of joint disorders like osteoarthritis (OA), a prevalent progressive degenerative joint disease that causes debilitating pain. Chondrocytes in the cartilage are responsible for extracellular matrix (ECM) turnover, and mechanical stimuli heavily influence cartilage maintenance, degeneration, and regeneration via mechanotransduction of chondrocytes. Thus, understanding the disease-associated mechanotransduction mechanisms can shed light on developing effective therapeutic strategies for OA through targeting mechanotransducers to halt progressive cartilage degeneration. Mechanosensitive Ca2+-permeating channels are robustly expressed in primary articular chondrocytes and trigger force-dependent cartilage remodeling and injury responses. This review discusses the current understanding of the roles of Piezo1, Piezo2, and TRPV4 mechanosensitive ion channels in cartilage health and disease with a highlight on the potential mechanotheraputic strategies to target these channels and prevent cartilage degeneration associated with OA.https://www.frontiersin.org/articles/10.3389/fcell.2022.885224/fullchondrocytemechanotransductionosteoarthritismechanically-activated calcium channelsPiezo1Piezo2 |
| spellingShingle | Winni Gao Hamza Hasan Devon E. Anderson Devon E. Anderson Whasil Lee Whasil Lee Whasil Lee Whasil Lee The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis Frontiers in Cell and Developmental Biology chondrocyte mechanotransduction osteoarthritis mechanically-activated calcium channels Piezo1 Piezo2 |
| title | The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis |
| title_full | The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis |
| title_fullStr | The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis |
| title_full_unstemmed | The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis |
| title_short | The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis |
| title_sort | role of mechanically activated ion channels piezo1 piezo2 and trpv4 in chondrocyte mechanotransduction and mechano therapeutics for osteoarthritis |
| topic | chondrocyte mechanotransduction osteoarthritis mechanically-activated calcium channels Piezo1 Piezo2 |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.885224/full |
| work_keys_str_mv | AT winnigao theroleofmechanicallyactivatedionchannelspiezo1piezo2andtrpv4inchondrocytemechanotransductionandmechanotherapeuticsforosteoarthritis AT hamzahasan theroleofmechanicallyactivatedionchannelspiezo1piezo2andtrpv4inchondrocytemechanotransductionandmechanotherapeuticsforosteoarthritis AT devoneanderson theroleofmechanicallyactivatedionchannelspiezo1piezo2andtrpv4inchondrocytemechanotransductionandmechanotherapeuticsforosteoarthritis AT devoneanderson theroleofmechanicallyactivatedionchannelspiezo1piezo2andtrpv4inchondrocytemechanotransductionandmechanotherapeuticsforosteoarthritis AT whasillee theroleofmechanicallyactivatedionchannelspiezo1piezo2andtrpv4inchondrocytemechanotransductionandmechanotherapeuticsforosteoarthritis AT whasillee theroleofmechanicallyactivatedionchannelspiezo1piezo2andtrpv4inchondrocytemechanotransductionandmechanotherapeuticsforosteoarthritis AT whasillee theroleofmechanicallyactivatedionchannelspiezo1piezo2andtrpv4inchondrocytemechanotransductionandmechanotherapeuticsforosteoarthritis AT whasillee theroleofmechanicallyactivatedionchannelspiezo1piezo2andtrpv4inchondrocytemechanotransductionandmechanotherapeuticsforosteoarthritis AT winnigao roleofmechanicallyactivatedionchannelspiezo1piezo2andtrpv4inchondrocytemechanotransductionandmechanotherapeuticsforosteoarthritis AT hamzahasan roleofmechanicallyactivatedionchannelspiezo1piezo2andtrpv4inchondrocytemechanotransductionandmechanotherapeuticsforosteoarthritis AT devoneanderson roleofmechanicallyactivatedionchannelspiezo1piezo2andtrpv4inchondrocytemechanotransductionandmechanotherapeuticsforosteoarthritis AT devoneanderson roleofmechanicallyactivatedionchannelspiezo1piezo2andtrpv4inchondrocytemechanotransductionandmechanotherapeuticsforosteoarthritis AT whasillee roleofmechanicallyactivatedionchannelspiezo1piezo2andtrpv4inchondrocytemechanotransductionandmechanotherapeuticsforosteoarthritis AT whasillee roleofmechanicallyactivatedionchannelspiezo1piezo2andtrpv4inchondrocytemechanotransductionandmechanotherapeuticsforosteoarthritis AT whasillee roleofmechanicallyactivatedionchannelspiezo1piezo2andtrpv4inchondrocytemechanotransductionandmechanotherapeuticsforosteoarthritis AT whasillee roleofmechanicallyactivatedionchannelspiezo1piezo2andtrpv4inchondrocytemechanotransductionandmechanotherapeuticsforosteoarthritis |