Can Inhibin B Reflect Ovarian Reserve of Healthy Reproductive Age Women Effectively?
ObjectiveThe reference range and potential value of inhibin B are still unclear and controversial. This study aimed to define the variation trend of inhibin B in healthy women with age and explore its value in the reflection of ovarian reserve.MethodsA total of 2524 healthy reproductive age women fr...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.626534/full |
| _version_ | 1818726978484699136 |
|---|---|
| author | Jingyi Wen Kecheng Huang Xiaofang Du Hanwang Zhang Ting Ding Cuilian Zhang Wenmin Ma Ying Zhong Wenyu Qu Yi Liu Zhiying Li Song Deng Aiyue Luo Yan Jin Jinjin Zhang Shixuan Wang |
| author_facet | Jingyi Wen Kecheng Huang Xiaofang Du Hanwang Zhang Ting Ding Cuilian Zhang Wenmin Ma Ying Zhong Wenyu Qu Yi Liu Zhiying Li Song Deng Aiyue Luo Yan Jin Jinjin Zhang Shixuan Wang |
| author_sort | Jingyi Wen |
| collection | DOAJ |
| description | ObjectiveThe reference range and potential value of inhibin B are still unclear and controversial. This study aimed to define the variation trend of inhibin B in healthy women with age and explore its value in the reflection of ovarian reserve.MethodsA total of 2524 healthy reproductive age women from eight medical institutes nationwide were recruited. The variation tendency of inhibin B with age was primarily established in the first group of 948 women and validated in another 605. We evaluated the relationship between inhibin B and classic ovarian reserve and function markers. The potency of inhibin B in predicting AFC <5-7 was also estimated and compared with FSH.ResultsThe nomogram showed that serum levels of inhibin B rapidly decreased after the age of 40. Inhibin B was positively correlated with AMH (R = 0.57, P < 0.001), AFC (R = 0.34, P < 0.001) and testosterone (R = 0.10, P = 0.002), and negatively correlated with FSH (R = -0.41, P < 0.001) and LH (R = -0.20, P < 0.001) and FSH/LH (R=-0.18, P < 0.001), while no correlation was found with PRL. Unexpectedly, Inhibin B (AUC = 0.74, P < 0.001 for the establishment population; AUC = 0.78, P < 0.001 for the validation population) had a slightly higher value than FSH (AUC = 0.71, P < 0.001 for the establishment population; AUC = 0.72, P < 0.001 for the validation population) in diagnosing AFC <5-7.ConclusionsFor healthy reproductive age women, the decline of inhibin B can reflect decreased ovarian reserve effectively, having a good consistency with AMH and AFC. More importantly, inhibin B had an advantage in predicting AFC <5-7 compared with FSH, which suggested the potential of inhibin B in predicting ovarian response. These results will be helpful to the clinical application of inhibin B in the evaluation of female ovarian reserve and the assessment of their reproductive capacity. Trial registration: http://clinicaltrials.gov; NCT02294500. |
| first_indexed | 2024-12-17T22:06:47Z |
| format | Article |
| id | doaj.art-57fe3ce69c004e158a4b2429a1b5b5f3 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-17T22:06:47Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-57fe3ce69c004e158a4b2429a1b5b5f32022-12-21T21:30:51ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-04-011210.3389/fendo.2021.626534626534Can Inhibin B Reflect Ovarian Reserve of Healthy Reproductive Age Women Effectively?Jingyi Wen0Kecheng Huang1Xiaofang Du2Hanwang Zhang3Ting Ding4Cuilian Zhang5Wenmin Ma6Ying Zhong7Wenyu Qu8Yi Liu9Zhiying Li10Song Deng11Aiyue Luo12Yan Jin13Jinjin Zhang14Shixuan Wang15Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaReproductive Medical Center, Henan Provincial People’s Hospital, Zhengzhou, ChinaReproductive Medical Center, Foshan Maternal and Child Health Care Hospital, Foshan, ChinaReproductive Medical Center, Chengdu Jinjiang Maternal and Child Health Hospital, Chengdu, ChinaReproductive Medical Center, Shenyang Women’s and Children’s Hospital, Shenyang, ChinaDepartment of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Renhe Hospital, China Three Gorges University, Yichang, ChinaDepartment of Gynecology, Minda Hospital of Hubei Minzu University, Enshi, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaObjectiveThe reference range and potential value of inhibin B are still unclear and controversial. This study aimed to define the variation trend of inhibin B in healthy women with age and explore its value in the reflection of ovarian reserve.MethodsA total of 2524 healthy reproductive age women from eight medical institutes nationwide were recruited. The variation tendency of inhibin B with age was primarily established in the first group of 948 women and validated in another 605. We evaluated the relationship between inhibin B and classic ovarian reserve and function markers. The potency of inhibin B in predicting AFC <5-7 was also estimated and compared with FSH.ResultsThe nomogram showed that serum levels of inhibin B rapidly decreased after the age of 40. Inhibin B was positively correlated with AMH (R = 0.57, P < 0.001), AFC (R = 0.34, P < 0.001) and testosterone (R = 0.10, P = 0.002), and negatively correlated with FSH (R = -0.41, P < 0.001) and LH (R = -0.20, P < 0.001) and FSH/LH (R=-0.18, P < 0.001), while no correlation was found with PRL. Unexpectedly, Inhibin B (AUC = 0.74, P < 0.001 for the establishment population; AUC = 0.78, P < 0.001 for the validation population) had a slightly higher value than FSH (AUC = 0.71, P < 0.001 for the establishment population; AUC = 0.72, P < 0.001 for the validation population) in diagnosing AFC <5-7.ConclusionsFor healthy reproductive age women, the decline of inhibin B can reflect decreased ovarian reserve effectively, having a good consistency with AMH and AFC. More importantly, inhibin B had an advantage in predicting AFC <5-7 compared with FSH, which suggested the potential of inhibin B in predicting ovarian response. These results will be helpful to the clinical application of inhibin B in the evaluation of female ovarian reserve and the assessment of their reproductive capacity. Trial registration: http://clinicaltrials.gov; NCT02294500.https://www.frontiersin.org/articles/10.3389/fendo.2021.626534/fullInhibin Bfollicle-stimulating hormoneanti-Mullerian hormoneantral follicle countovarian reservefertility |
| spellingShingle | Jingyi Wen Kecheng Huang Xiaofang Du Hanwang Zhang Ting Ding Cuilian Zhang Wenmin Ma Ying Zhong Wenyu Qu Yi Liu Zhiying Li Song Deng Aiyue Luo Yan Jin Jinjin Zhang Shixuan Wang Can Inhibin B Reflect Ovarian Reserve of Healthy Reproductive Age Women Effectively? Frontiers in Endocrinology Inhibin B follicle-stimulating hormone anti-Mullerian hormone antral follicle count ovarian reserve fertility |
| title | Can Inhibin B Reflect Ovarian Reserve of Healthy Reproductive Age Women Effectively? |
| title_full | Can Inhibin B Reflect Ovarian Reserve of Healthy Reproductive Age Women Effectively? |
| title_fullStr | Can Inhibin B Reflect Ovarian Reserve of Healthy Reproductive Age Women Effectively? |
| title_full_unstemmed | Can Inhibin B Reflect Ovarian Reserve of Healthy Reproductive Age Women Effectively? |
| title_short | Can Inhibin B Reflect Ovarian Reserve of Healthy Reproductive Age Women Effectively? |
| title_sort | can inhibin b reflect ovarian reserve of healthy reproductive age women effectively |
| topic | Inhibin B follicle-stimulating hormone anti-Mullerian hormone antral follicle count ovarian reserve fertility |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.626534/full |
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