Multiplex malaria antigen detection by bead-based assay and molecular confirmation by PCR shows no evidence of Pfhrp2 and Pfhrp3 deletion in Haiti

Multiplex malaria antigen detection by bead-based assay and molecular confirmation by PCR shows no evidence of Pfhrp2 and Pfhrp3 deletion in Haiti

Abstract Background The Plasmodium falciparum parasite is the only human malaria that produces the histidine-rich protein 2 and 3 (HRP2/3) antigens. Currently, HRP2/3 are widely used in malaria rapid diagnostic tests (RDTs), but several global reports have recently emerged showing genetic deletion o...

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Bibliographic Details
Main Authors: Camelia Herman, Curtis S. Huber, Sophie Jones, Laura Steinhardt, Mateusz M. Plucinski, Jean F. Lemoine, Michelle Chang, John W. Barnwell, Venkatachalam Udhayakumar, Eric Rogier
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Malaria Journal
Subjects:
Haiti
Rapid diagnostic test
HRP2 deletion
Plasmodium aldolase
Plasmodium lactate dehydrogenase
Pfhrp2
Online Access:http://link.springer.com/article/10.1186/s12936-019-3010-9

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