A case of benign immunoglobulin D monoclonal gammopathy of undetermined significance with 26 years of follow‐up
Abstract The presence of a serum immunoglobulin D (IgD) monoclonal protein (M‐protein) is seen in < 1% of patients with monoclonal gammopathies and is usually indicative of a malignant plasma cell disorder. Only a few cases of well‐documented benign monoclonal gammopathy of undetermined significa...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | eJHaem |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jha2.846 |
| _version_ | 1797296732409692160 |
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| author | Larry D. Anderson Jr. Joan Bladé Robert A. Kyle |
| author_facet | Larry D. Anderson Jr. Joan Bladé Robert A. Kyle |
| author_sort | Larry D. Anderson Jr. |
| collection | DOAJ |
| description | Abstract The presence of a serum immunoglobulin D (IgD) monoclonal protein (M‐protein) is seen in < 1% of patients with monoclonal gammopathies and is usually indicative of a malignant plasma cell disorder. Only a few cases of well‐documented benign monoclonal gammopathy of undetermined significance (MGUS) of IgD subtype have been reported, and only 2 of those had over 5 years of follow‐up at the time they were reported. Herein we describe longer‐term follow‐up of one of those 2 patients who has subsequently passed away from unrelated causes but never developed multiple myeloma or amyloidosis after 26 years of follow‐up. Although IgD MGUS is extremely rare, this case confirms that presence of an IgD M‐Protein is not always synonymous with a malignant plasma cell process. |
| first_indexed | 2024-03-07T22:09:03Z |
| format | Article |
| id | doaj.art-58010004b4124418a7ccc4c1797b5a59 |
| institution | Directory Open Access Journal |
| issn | 2688-6146 |
| language | English |
| last_indexed | 2024-03-07T22:09:03Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj.art-58010004b4124418a7ccc4c1797b5a592024-02-23T16:50:43ZengWileyeJHaem2688-61462024-02-015123523710.1002/jha2.846A case of benign immunoglobulin D monoclonal gammopathy of undetermined significance with 26 years of follow‐upLarry D. Anderson Jr.0Joan Bladé1Robert A. Kyle2Myeloma, Waldenstrom's, and Amyloidosis Program Hematologic Malignancies and Cellular Therapy Program Simmons Comprehensive Cancer Center UT Southwestern Medical Center Dallas Texas USADepartment of Hematology Amyloidosis and Myeloma Unit Institut d'Investigacions Biomèdiques August Pi i Sunyer Hospital Clínic de Barcelona University de Barcelona Barcelona SpainDivision of Hematology Mayo Clinic Rochester Minnesota USAAbstract The presence of a serum immunoglobulin D (IgD) monoclonal protein (M‐protein) is seen in < 1% of patients with monoclonal gammopathies and is usually indicative of a malignant plasma cell disorder. Only a few cases of well‐documented benign monoclonal gammopathy of undetermined significance (MGUS) of IgD subtype have been reported, and only 2 of those had over 5 years of follow‐up at the time they were reported. Herein we describe longer‐term follow‐up of one of those 2 patients who has subsequently passed away from unrelated causes but never developed multiple myeloma or amyloidosis after 26 years of follow‐up. Although IgD MGUS is extremely rare, this case confirms that presence of an IgD M‐Protein is not always synonymous with a malignant plasma cell process.https://doi.org/10.1002/jha2.846Immunoglobulin D (IgD)MGUSmonoclonal gammopathy |
| spellingShingle | Larry D. Anderson Jr. Joan Bladé Robert A. Kyle A case of benign immunoglobulin D monoclonal gammopathy of undetermined significance with 26 years of follow‐up eJHaem Immunoglobulin D (IgD) MGUS monoclonal gammopathy |
| title | A case of benign immunoglobulin D monoclonal gammopathy of undetermined significance with 26 years of follow‐up |
| title_full | A case of benign immunoglobulin D monoclonal gammopathy of undetermined significance with 26 years of follow‐up |
| title_fullStr | A case of benign immunoglobulin D monoclonal gammopathy of undetermined significance with 26 years of follow‐up |
| title_full_unstemmed | A case of benign immunoglobulin D monoclonal gammopathy of undetermined significance with 26 years of follow‐up |
| title_short | A case of benign immunoglobulin D monoclonal gammopathy of undetermined significance with 26 years of follow‐up |
| title_sort | case of benign immunoglobulin d monoclonal gammopathy of undetermined significance with 26 years of follow up |
| topic | Immunoglobulin D (IgD) MGUS monoclonal gammopathy |
| url | https://doi.org/10.1002/jha2.846 |
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