Structural basis for specific inhibition of the deubiquitinase UCHL1
The deubiquitinase UCHL1 has been linked to cancer invasiveness and neurodegeneration yet its molecular roles have remained poorly defined. Here the authors reveal the structural basis for how UCHL1 can be specifically inhibited and how chemogenomic probes can be used to dissect its functions in liv...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33559-4 |
| _version_ | 1798029924945100800 |
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| author | Christian Grethe Mirko Schmidt Gian-Marvin Kipka Rachel O’Dea Kai Gallant Petra Janning Malte Gersch |
| author_facet | Christian Grethe Mirko Schmidt Gian-Marvin Kipka Rachel O’Dea Kai Gallant Petra Janning Malte Gersch |
| author_sort | Christian Grethe |
| collection | DOAJ |
| description | The deubiquitinase UCHL1 has been linked to cancer invasiveness and neurodegeneration yet its molecular roles have remained poorly defined. Here the authors reveal the structural basis for how UCHL1 can be specifically inhibited and how chemogenomic probes can be used to dissect its functions in living cells. |
| first_indexed | 2024-04-11T19:32:50Z |
| format | Article |
| id | doaj.art-580159e76e74442fa75b07a808c4dac7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T19:32:50Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-580159e76e74442fa75b07a808c4dac72022-12-22T04:06:57ZengNature PortfolioNature Communications2041-17232022-10-0113111710.1038/s41467-022-33559-4Structural basis for specific inhibition of the deubiquitinase UCHL1Christian Grethe0Mirko Schmidt1Gian-Marvin Kipka2Rachel O’Dea3Kai Gallant4Petra Janning5Malte Gersch6Max Planck Institute of Molecular Physiology, Chemical Genomics CentreMax Planck Institute of Molecular Physiology, Chemical Genomics CentreMax Planck Institute of Molecular Physiology, Chemical Genomics CentreMax Planck Institute of Molecular Physiology, Chemical Genomics CentreMax Planck Institute of Molecular Physiology, Chemical Genomics CentreMax Planck Institute of Molecular Physiology, Department of Chemical BiologyMax Planck Institute of Molecular Physiology, Chemical Genomics CentreThe deubiquitinase UCHL1 has been linked to cancer invasiveness and neurodegeneration yet its molecular roles have remained poorly defined. Here the authors reveal the structural basis for how UCHL1 can be specifically inhibited and how chemogenomic probes can be used to dissect its functions in living cells.https://doi.org/10.1038/s41467-022-33559-4 |
| spellingShingle | Christian Grethe Mirko Schmidt Gian-Marvin Kipka Rachel O’Dea Kai Gallant Petra Janning Malte Gersch Structural basis for specific inhibition of the deubiquitinase UCHL1 Nature Communications |
| title | Structural basis for specific inhibition of the deubiquitinase UCHL1 |
| title_full | Structural basis for specific inhibition of the deubiquitinase UCHL1 |
| title_fullStr | Structural basis for specific inhibition of the deubiquitinase UCHL1 |
| title_full_unstemmed | Structural basis for specific inhibition of the deubiquitinase UCHL1 |
| title_short | Structural basis for specific inhibition of the deubiquitinase UCHL1 |
| title_sort | structural basis for specific inhibition of the deubiquitinase uchl1 |
| url | https://doi.org/10.1038/s41467-022-33559-4 |
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