Deficiency of the RIβ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats

Deficiency of the RIβ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats

Abstract The RIβ subunit of cAMP-dependent protein kinase (PKA), encoded by Prkar1b, is a neuronal isoform of the type I regulatory subunit of PKA. Mice lacking the RIβ subunit exhibit normal long-term potentiation (LTP) in the Schaffer collateral pathway of the hippocampus and normal behavior in th...

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Main Authors: Hieu Hoang Trung, Toru Yoshihara, Akito Nakao, Katsumi Hayashida, Yoshiki Hirata, Koumei Shirasuna, Mitsuru Kuwamura, Yuki Nakagawa, Takehito Kaneko, Yasuo Mori, Masahide Asano, Takashi Kuramoto
Format: Article
Language:English
Published: Nature Portfolio 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-81515-x

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