Comparing Kojic Acid Cream 2% with Glycolic Acid 10% and Hydroquinone Cream 2% in Treatment of Melasma
Background: Melasma is a common acquired hypermelanosis in areas exposed to sunlight, which exacerbates with sunlight, pregnancy, and endocrine diseases. Melasma is problematic regarding cosmetic especially in women. Many drugs have been used for its treatment, but regarding side effects, they have...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2014-03-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/2524 |
| _version_ | 1827843085492551680 |
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| author | Fariba Iraji Ali Asililan Fatemeh Fadaei Mohammad Ali Nilforoushzadeh |
| author_facet | Fariba Iraji Ali Asililan Fatemeh Fadaei Mohammad Ali Nilforoushzadeh |
| author_sort | Fariba Iraji |
| collection | DOAJ |
| description | Background: Melasma is a common acquired hypermelanosis in areas exposed to sunlight, which exacerbates with sunlight, pregnancy, and endocrine diseases. Melasma is problematic regarding cosmetic especially in women. Many drugs have been used for its treatment, but regarding side effects, they have limited relative usage. Therefore, testing a new drug with higher effectiveness and fewer side effects is necessary. This study attempted to evaluate the effectiveness of kojic acid on melasma.
Methods: In this study double-blind clinical trial study, 40 patients with melasma were enroled. One group of 20 people received kojic acid cream 2%, and the other used glycolic acid 10% and hydroquinone cream 2%. In the first group, 43 pigmented macules and in the second group, 21 pigmented macules existed. The changes of pigments in terms of recovery time, color tone and size of the pigments over a three-month treatment period was evaluated with clinical assessment, completing monthly questionnaire, and in a few cases with the aid of Wood's lamp. After the three-month treatment period, the collected data using the Friedman test, t-test were analyzed.
Findings: In total, 79% of the patients were cured after 3 months. According to Friedman test, regarding healing time of the pigment, there was a significant difference between the groups (P = 0.008). Regarding the color tone changes of the pigment at the end of the second and third months, there was a significant difference between the two groups.
Conclousion: Kojic acid 2% cream has a good efficacy in the treatment of melasma with no serious complications. |
| first_indexed | 2024-03-12T08:19:41Z |
| format | Article |
| id | doaj.art-5803fe1b6da9490a9480103d4c019592 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T08:19:41Z |
| publishDate | 2014-03-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-5803fe1b6da9490a9480103d4c0195922023-09-02T18:35:49ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2014-03-0131269229523301506Comparing Kojic Acid Cream 2% with Glycolic Acid 10% and Hydroquinone Cream 2% in Treatment of MelasmaFariba Iraji0Ali Asililan1Fatemeh Fadaei2Mohammad Ali Nilforoushzadeh3Associate Professor, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan,IranProfessor, Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudent of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran AND Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, IranBackground: Melasma is a common acquired hypermelanosis in areas exposed to sunlight, which exacerbates with sunlight, pregnancy, and endocrine diseases. Melasma is problematic regarding cosmetic especially in women. Many drugs have been used for its treatment, but regarding side effects, they have limited relative usage. Therefore, testing a new drug with higher effectiveness and fewer side effects is necessary. This study attempted to evaluate the effectiveness of kojic acid on melasma. Methods: In this study double-blind clinical trial study, 40 patients with melasma were enroled. One group of 20 people received kojic acid cream 2%, and the other used glycolic acid 10% and hydroquinone cream 2%. In the first group, 43 pigmented macules and in the second group, 21 pigmented macules existed. The changes of pigments in terms of recovery time, color tone and size of the pigments over a three-month treatment period was evaluated with clinical assessment, completing monthly questionnaire, and in a few cases with the aid of Wood's lamp. After the three-month treatment period, the collected data using the Friedman test, t-test were analyzed. Findings: In total, 79% of the patients were cured after 3 months. According to Friedman test, regarding healing time of the pigment, there was a significant difference between the groups (P = 0.008). Regarding the color tone changes of the pigment at the end of the second and third months, there was a significant difference between the two groups. Conclousion: Kojic acid 2% cream has a good efficacy in the treatment of melasma with no serious complications.http://jims.mui.ac.ir/index.php/jims/article/view/2524MelasmaTreatment of melasmaTopical treatment of melasmaKojic acid |
| spellingShingle | Fariba Iraji Ali Asililan Fatemeh Fadaei Mohammad Ali Nilforoushzadeh Comparing Kojic Acid Cream 2% with Glycolic Acid 10% and Hydroquinone Cream 2% in Treatment of Melasma مجله دانشکده پزشکی اصفهان Melasma Treatment of melasma Topical treatment of melasma Kojic acid |
| title | Comparing Kojic Acid Cream 2% with Glycolic Acid 10% and Hydroquinone Cream 2% in Treatment of Melasma |
| title_full | Comparing Kojic Acid Cream 2% with Glycolic Acid 10% and Hydroquinone Cream 2% in Treatment of Melasma |
| title_fullStr | Comparing Kojic Acid Cream 2% with Glycolic Acid 10% and Hydroquinone Cream 2% in Treatment of Melasma |
| title_full_unstemmed | Comparing Kojic Acid Cream 2% with Glycolic Acid 10% and Hydroquinone Cream 2% in Treatment of Melasma |
| title_short | Comparing Kojic Acid Cream 2% with Glycolic Acid 10% and Hydroquinone Cream 2% in Treatment of Melasma |
| title_sort | comparing kojic acid cream 2 with glycolic acid 10 and hydroquinone cream 2 in treatment of melasma |
| topic | Melasma Treatment of melasma Topical treatment of melasma Kojic acid |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/2524 |
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