Clinical prediction models of rheumatoid arthritis and its complications: focus on cardiovascular disease and interstitial lung disease
Abstract Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disease of unknown etiology with erosive, symmetric polyarthritis as the main clinical manifestations. Its basic pathological changes are the formation of synovitis, and patients gradually develop destruction of articular cartilag...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13075-023-03140-5 |
| _version_ | 1797451889336385536 |
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| author | Yubo Shao Hong Zhang Qi Shi Yongjun Wang Qianqian Liang |
| author_facet | Yubo Shao Hong Zhang Qi Shi Yongjun Wang Qianqian Liang |
| author_sort | Yubo Shao |
| collection | DOAJ |
| description | Abstract Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disease of unknown etiology with erosive, symmetric polyarthritis as the main clinical manifestations. Its basic pathological changes are the formation of synovitis, and patients gradually develop destruction of articular cartilage destruction and bone erosion, which eventually leads to joint deformity, disability, and various extra-articular manifestations. Clinical prediction models (CPMs), also known as risk prediction models or risk scores, are mathematical formulas used to estimate the probability that a given individual will have a disease or an outcome in the future. The models are mainly divided into two categories: diagnostic models and prognostic models, which can be used to provide information on disease diagnosis or prognosis to help make better medical decisions. Currently, there is no cure for RA, but effective early diagnosis and treatment are crucial for limiting the severity of the disease and preventing the occurrence and development of complications. This paper reviews the CPMs associated with RA and its related complications, including cardiovascular disease (CVD) and interstitial lung disease (ILD), in order to provide reference and evidence for the early diagnosis and treatment of these diseases and personalized medicine for patients. In addition, the possible pathogenesis and risk factors of these comorbidities are summarized, and possible directions for future related research are prospected. |
| first_indexed | 2024-03-09T15:00:57Z |
| format | Article |
| id | doaj.art-58065b41319b40d49055369264929680 |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-03-09T15:00:57Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-58065b41319b40d490553692649296802023-11-26T13:54:38ZengBMCArthritis Research & Therapy1478-63622023-09-0125111410.1186/s13075-023-03140-5Clinical prediction models of rheumatoid arthritis and its complications: focus on cardiovascular disease and interstitial lung diseaseYubo Shao0Hong Zhang1Qi Shi2Yongjun Wang3Qianqian Liang4Longhua Hospital, Shanghai University of Traditional Chinese MedicineLonghua Hospital, Shanghai University of Traditional Chinese MedicineLonghua Hospital, Shanghai University of Traditional Chinese MedicineLonghua Hospital, Shanghai University of Traditional Chinese MedicineLonghua Hospital, Shanghai University of Traditional Chinese MedicineAbstract Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disease of unknown etiology with erosive, symmetric polyarthritis as the main clinical manifestations. Its basic pathological changes are the formation of synovitis, and patients gradually develop destruction of articular cartilage destruction and bone erosion, which eventually leads to joint deformity, disability, and various extra-articular manifestations. Clinical prediction models (CPMs), also known as risk prediction models or risk scores, are mathematical formulas used to estimate the probability that a given individual will have a disease or an outcome in the future. The models are mainly divided into two categories: diagnostic models and prognostic models, which can be used to provide information on disease diagnosis or prognosis to help make better medical decisions. Currently, there is no cure for RA, but effective early diagnosis and treatment are crucial for limiting the severity of the disease and preventing the occurrence and development of complications. This paper reviews the CPMs associated with RA and its related complications, including cardiovascular disease (CVD) and interstitial lung disease (ILD), in order to provide reference and evidence for the early diagnosis and treatment of these diseases and personalized medicine for patients. In addition, the possible pathogenesis and risk factors of these comorbidities are summarized, and possible directions for future related research are prospected.https://doi.org/10.1186/s13075-023-03140-5Rheumatoid arthritisCardiovascular diseaseInterstitial lung diseasePrediction modelsPathogenesis |
| spellingShingle | Yubo Shao Hong Zhang Qi Shi Yongjun Wang Qianqian Liang Clinical prediction models of rheumatoid arthritis and its complications: focus on cardiovascular disease and interstitial lung disease Arthritis Research & Therapy Rheumatoid arthritis Cardiovascular disease Interstitial lung disease Prediction models Pathogenesis |
| title | Clinical prediction models of rheumatoid arthritis and its complications: focus on cardiovascular disease and interstitial lung disease |
| title_full | Clinical prediction models of rheumatoid arthritis and its complications: focus on cardiovascular disease and interstitial lung disease |
| title_fullStr | Clinical prediction models of rheumatoid arthritis and its complications: focus on cardiovascular disease and interstitial lung disease |
| title_full_unstemmed | Clinical prediction models of rheumatoid arthritis and its complications: focus on cardiovascular disease and interstitial lung disease |
| title_short | Clinical prediction models of rheumatoid arthritis and its complications: focus on cardiovascular disease and interstitial lung disease |
| title_sort | clinical prediction models of rheumatoid arthritis and its complications focus on cardiovascular disease and interstitial lung disease |
| topic | Rheumatoid arthritis Cardiovascular disease Interstitial lung disease Prediction models Pathogenesis |
| url | https://doi.org/10.1186/s13075-023-03140-5 |
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