Is type 2 diabetes associated dementia a microvascular early-Alzheimer’s phenotype induced by aberrations in the peripheral metabolism of lipoprotein-amyloid?

Is type 2 diabetes associated dementia a microvascular early-Alzheimer’s phenotype induced by aberrations in the peripheral metabolism of lipoprotein-amyloid?

There is increasing evidence of a positive association of type 2 diabetes with Alzheimer’s disease (AD), the most prevalent form of dementia. Suggested pathways include cerebral vascular dysfunction; central insulin resistance, or exaggerated brain abundance of potentially cytotoxic amyloid-β (Aβ),...

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Bibliographic Details
Main Authors: Ryusuke Takechi, Arazu Sharif, Emily Brook, Maimuna Majimbi, Dick C. Chan, Virginie Lam, Gerald F. Watts, John C. L. Mamo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Endocrinology
Subjects:
amyloid
diabetes
Alzheimer’s
lipoprotein
triglycerides
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1127481/full

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