Prevalence of hepatitis B markers seropositivity in sickle cell (SCA) children in ABUTH Shika, Kaduna State
Background: The study was carried out to determine the scope and pattern of hepatitis B infection among patient with sickle cell disease presenting at ABUTH Shika. Aims and objectives. This research work was conducted to determine the seropositivity of HBV infection amongst SCA patients and also to...
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| Language: | English |
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Nigerian Medical Association, Akwa Ibom State Branch
2021-07-01
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| Series: | Ibom Medical Journal |
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| Online Access: | https://ibommedicaljournal.org/index.php/imjhome/article/view/44 |
| _version_ | 1797271874001960960 |
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| author | Aliyu-zubair R Yakubu AM Ogurinde GO Ibrahim A Olayinka A |
| author_facet | Aliyu-zubair R Yakubu AM Ogurinde GO Ibrahim A Olayinka A |
| author_sort | Aliyu-zubair R |
| collection | DOAJ |
| description |
Background: The study was carried out to determine the scope and pattern of hepatitis B infection among patient with sickle cell disease presenting at ABUTH Shika. Aims and objectives. This research work was conducted to determine the seropositivity of HBV infection amongst SCA patients and also to determine the associated potential risk in the acquisition of the infection.
Patients and method: In order to determine the pattern of HBV infection among children with SCA aged 6 months to 12 years and associated risk factors; a random selection of 146 children was made at the paediatric haematology clinic of Ahmadu Bello University Teaching Hospital, Shika. For each SCA patient, an age-and sex- matched control with genotype AA presenting with minor ailments were selected from the paediatric outpatient of the hospital. The children were screened for various markers of hepatitis B virus using a spot test and ELISA test.
Results: The prevalence rates of hepatitis B infection documented in the SCA and control groups were 24.66% and 28.77% respectively. The prevalence was highest in 9 - 12 year age group for both SCA patients and controls with prevalence of 42.86% and 42.11% respectively. None of the risk factors studied which included blood transfusions, parenteral injections, hospitalization, ulcers, tattooing, traditional circumcision, ear piercing, traditional scarification and contact with known hepatitis case were significantly associated with HBV infection in either the SCA or control group. There was also no association between frequency of hospitalizations, transfusions and people sleeping in the same room with HBV infection in either SCA patients or the control groups. The most frequent marker found among both the SCA and control group was anti-HBc.
Conclusion: High prevalence of HBV infection was detected in both the subjects and controls. Children with SCA were not found to be at increased risk of contracting hepatitis B infection. It is recommended that all children should benefit from early vaccination.
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| first_indexed | 2024-03-07T14:16:28Z |
| format | Article |
| id | doaj.art-58089e05552e49a3b7e03e30f8bc1cae |
| institution | Directory Open Access Journal |
| issn | 1597-7188 2735-9964 |
| language | English |
| last_indexed | 2024-03-07T14:16:28Z |
| publishDate | 2021-07-01 |
| publisher | Nigerian Medical Association, Akwa Ibom State Branch |
| record_format | Article |
| series | Ibom Medical Journal |
| spelling | doaj.art-58089e05552e49a3b7e03e30f8bc1cae2024-03-06T12:03:23ZengNigerian Medical Association, Akwa Ibom State BranchIbom Medical Journal1597-71882735-99642021-07-0114310.61386/imj.v14i3.44Prevalence of hepatitis B markers seropositivity in sickle cell (SCA) children in ABUTH Shika, Kaduna StateAliyu-zubair R0Yakubu AMOgurinde GOIbrahim AOlayinka ADepartment of Paediatrics, Barau Dikko Teaching Hospital, Kaduna State University, Kaduna Nigeria Background: The study was carried out to determine the scope and pattern of hepatitis B infection among patient with sickle cell disease presenting at ABUTH Shika. Aims and objectives. This research work was conducted to determine the seropositivity of HBV infection amongst SCA patients and also to determine the associated potential risk in the acquisition of the infection. Patients and method: In order to determine the pattern of HBV infection among children with SCA aged 6 months to 12 years and associated risk factors; a random selection of 146 children was made at the paediatric haematology clinic of Ahmadu Bello University Teaching Hospital, Shika. For each SCA patient, an age-and sex- matched control with genotype AA presenting with minor ailments were selected from the paediatric outpatient of the hospital. The children were screened for various markers of hepatitis B virus using a spot test and ELISA test. Results: The prevalence rates of hepatitis B infection documented in the SCA and control groups were 24.66% and 28.77% respectively. The prevalence was highest in 9 - 12 year age group for both SCA patients and controls with prevalence of 42.86% and 42.11% respectively. None of the risk factors studied which included blood transfusions, parenteral injections, hospitalization, ulcers, tattooing, traditional circumcision, ear piercing, traditional scarification and contact with known hepatitis case were significantly associated with HBV infection in either the SCA or control group. There was also no association between frequency of hospitalizations, transfusions and people sleeping in the same room with HBV infection in either SCA patients or the control groups. The most frequent marker found among both the SCA and control group was anti-HBc. Conclusion: High prevalence of HBV infection was detected in both the subjects and controls. Children with SCA were not found to be at increased risk of contracting hepatitis B infection. It is recommended that all children should benefit from early vaccination. https://ibommedicaljournal.org/index.php/imjhome/article/view/44Hepatitis B virusSickle cell anaemiaPaediatric outpatient departmentEnzyme linked immunosorbent assay Introduction |
| spellingShingle | Aliyu-zubair R Yakubu AM Ogurinde GO Ibrahim A Olayinka A Prevalence of hepatitis B markers seropositivity in sickle cell (SCA) children in ABUTH Shika, Kaduna State Ibom Medical Journal Hepatitis B virus Sickle cell anaemia Paediatric outpatient department Enzyme linked immunosorbent assay Introduction |
| title | Prevalence of hepatitis B markers seropositivity in sickle cell (SCA) children in ABUTH Shika, Kaduna State |
| title_full | Prevalence of hepatitis B markers seropositivity in sickle cell (SCA) children in ABUTH Shika, Kaduna State |
| title_fullStr | Prevalence of hepatitis B markers seropositivity in sickle cell (SCA) children in ABUTH Shika, Kaduna State |
| title_full_unstemmed | Prevalence of hepatitis B markers seropositivity in sickle cell (SCA) children in ABUTH Shika, Kaduna State |
| title_short | Prevalence of hepatitis B markers seropositivity in sickle cell (SCA) children in ABUTH Shika, Kaduna State |
| title_sort | prevalence of hepatitis b markers seropositivity in sickle cell sca children in abuth shika kaduna state |
| topic | Hepatitis B virus Sickle cell anaemia Paediatric outpatient department Enzyme linked immunosorbent assay Introduction |
| url | https://ibommedicaljournal.org/index.php/imjhome/article/view/44 |
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