Erythrocytes and Nanoparticles: New Therapeutic Systems
Nano-delivery systems represent one of the most studied fields, thanks to the associated improvement in the treatment of human diseases. The functionality of nanostructures is a crucial point, which the effectiveness of nanodrugs depends on. A hybrid approach strategy using synthetic nanoparticles (...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/5/2173 |
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| author | Clara Guido Gabriele Maiorano Carmen Gutiérrez-Millán Barbara Cortese Adriana Trapani Stefania D’Amone Giuseppe Gigli Ilaria Elena Palamà |
| author_facet | Clara Guido Gabriele Maiorano Carmen Gutiérrez-Millán Barbara Cortese Adriana Trapani Stefania D’Amone Giuseppe Gigli Ilaria Elena Palamà |
| author_sort | Clara Guido |
| collection | DOAJ |
| description | Nano-delivery systems represent one of the most studied fields, thanks to the associated improvement in the treatment of human diseases. The functionality of nanostructures is a crucial point, which the effectiveness of nanodrugs depends on. A hybrid approach strategy using synthetic nanoparticles (NPs) and erythrocytes offers an optimal blend of natural and synthetic materials. This, in turn, allows medical practitioners to exploit the combined advantages of erythrocytes and NPs. Erythrocyte-based drug delivery systems have been investigated for their biocompatibility, as well as the long circulation time allowed by specific surface receptors that inhibit immune clearance. In this review, we will discuss several methods—whole erythrocytes as drug carriers, red blood cell membrane-camouflaged nanoparticles and nano-erythrosomes (NERs)—while paying attention to their application and specific preparation methods. The ability to target cells makes erythrocytes excellent drug delivery systems. They can carry a wide range of therapeutic molecules while also acting as bioreactors; thus, they have many applications in therapy and in the diagnosis of many diseases. |
| first_indexed | 2024-03-09T06:01:10Z |
| format | Article |
| id | doaj.art-580902c98e1645d2b19863620cc40758 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T06:01:10Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-580902c98e1645d2b19863620cc407582023-12-03T12:08:37ZengMDPI AGApplied Sciences2076-34172021-03-01115217310.3390/app11052173Erythrocytes and Nanoparticles: New Therapeutic SystemsClara Guido0Gabriele Maiorano1Carmen Gutiérrez-Millán2Barbara Cortese3Adriana Trapani4Stefania D’Amone5Giuseppe Gigli6Ilaria Elena Palamà7Department of Mathematics and Physics, University of Salento, Monteroni Street, 73100 Lecce, ItalyNanotechnology Institute, CNR-NANOTEC, Monteroni Street, 73100 Lecce, ItalyArea of Pharmacy and Pharmaceutical Technology, Department of Pharmaceutical Sciences, The Institute for Biomedical Research of Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, SpainNanotechnology Institute, CNR-NANOTEC, c/o La Sapienza University, Piazzale A. Moro, 00185 Roma, ItalyDepartment of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, 70125 Bari, ItalyNanotechnology Institute, CNR-NANOTEC, Monteroni Street, 73100 Lecce, ItalyDepartment of Mathematics and Physics, University of Salento, Monteroni Street, 73100 Lecce, ItalyNanotechnology Institute, CNR-NANOTEC, Monteroni Street, 73100 Lecce, ItalyNano-delivery systems represent one of the most studied fields, thanks to the associated improvement in the treatment of human diseases. The functionality of nanostructures is a crucial point, which the effectiveness of nanodrugs depends on. A hybrid approach strategy using synthetic nanoparticles (NPs) and erythrocytes offers an optimal blend of natural and synthetic materials. This, in turn, allows medical practitioners to exploit the combined advantages of erythrocytes and NPs. Erythrocyte-based drug delivery systems have been investigated for their biocompatibility, as well as the long circulation time allowed by specific surface receptors that inhibit immune clearance. In this review, we will discuss several methods—whole erythrocytes as drug carriers, red blood cell membrane-camouflaged nanoparticles and nano-erythrosomes (NERs)—while paying attention to their application and specific preparation methods. The ability to target cells makes erythrocytes excellent drug delivery systems. They can carry a wide range of therapeutic molecules while also acting as bioreactors; thus, they have many applications in therapy and in the diagnosis of many diseases.https://www.mdpi.com/2076-3417/11/5/2173erythrocytenanoparticlescarrier into carrier |
| spellingShingle | Clara Guido Gabriele Maiorano Carmen Gutiérrez-Millán Barbara Cortese Adriana Trapani Stefania D’Amone Giuseppe Gigli Ilaria Elena Palamà Erythrocytes and Nanoparticles: New Therapeutic Systems Applied Sciences erythrocyte nanoparticles carrier into carrier |
| title | Erythrocytes and Nanoparticles: New Therapeutic Systems |
| title_full | Erythrocytes and Nanoparticles: New Therapeutic Systems |
| title_fullStr | Erythrocytes and Nanoparticles: New Therapeutic Systems |
| title_full_unstemmed | Erythrocytes and Nanoparticles: New Therapeutic Systems |
| title_short | Erythrocytes and Nanoparticles: New Therapeutic Systems |
| title_sort | erythrocytes and nanoparticles new therapeutic systems |
| topic | erythrocyte nanoparticles carrier into carrier |
| url | https://www.mdpi.com/2076-3417/11/5/2173 |
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