| Summary: | Paralytic shellfish toxins (PSTs) are an increasingly important source of pollution. Bivalves, as the main transmission medium, accumulate and metabolize PSTs while protecting themselves from damage. At present, the resistance mechanism of bivalves to PSTs is unclear. In this study, <i>Mytilus galloprovincialis</i> and <i>Argopecten irradians</i> were used as experimental shellfish species for in situ monitoring. We compared the inflammatory-related gene responses of the two shellfish during PSTs exposure by using transcriptomes. The results showed that the accumulation and metabolism rate of PSTs in <i>M. galloprovincialis</i> was five-fold higher than that in <i>A. irradians</i>. The inflammatory balance mechanism of <i>M. galloprovincialis</i> involved the co-regulation of the MAPK-based and AMPK-based anti-inflammatory pathways. <i>A. irradians</i> bore a higher risk of death because it did not have the balance system, and the regulation of apoptosis-related pathways such as the PI3K-AKT signaling pathway were upregulated. Taken together, the regulation of the inflammatory balance coincides with the ability of bivalves to cope with PSTs. Inflammation is an important factor that affects the metabolic pattern of PSTs in bivalves. This study provides new evidence to support the studies on the resistance mechanism of bivalves to PSTs.
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