Association between ABO blood group and unfavorable prostate cancer features after radical prostatectomy: Retrospective study of 1149 patients
Abstract. Objectives. To test hypothesized associations between the ABO blood group (ABO-bg) system and the pathological features of prostate cancer (PCa). Material and methods. Between January 2013 and September 2019, 1173 patients underwent radical prostatectomy. Associations between ABO-bg levels...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health
2022-12-01
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| Series: | Current Urology |
| Online Access: | http://journals.lww.com/10.1097/CU9.0000000000000146 |
| _version_ | 1797945039125479424 |
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| author | Antonio Benito Porcaro Nelia Amigoni Riccardo Rizzetto Filippo Migliorini Alessandro Tafuri Pierluigi Piccoli Leone Tiso Mario De Michele Alberto Bianchi Sebastian Gallina Paola Irene Ornaghi Rossella Orlando Francesco Cianflone Alessandra Gozzo Stefano Zecchini Antoniolli Vincenzo Lacola Matteo Brunelli Maria Angela Cerruto Walter Artibani Alessandro Antonelli |
| author_facet | Antonio Benito Porcaro Nelia Amigoni Riccardo Rizzetto Filippo Migliorini Alessandro Tafuri Pierluigi Piccoli Leone Tiso Mario De Michele Alberto Bianchi Sebastian Gallina Paola Irene Ornaghi Rossella Orlando Francesco Cianflone Alessandra Gozzo Stefano Zecchini Antoniolli Vincenzo Lacola Matteo Brunelli Maria Angela Cerruto Walter Artibani Alessandro Antonelli |
| author_sort | Antonio Benito Porcaro |
| collection | DOAJ |
| description | Abstract. Objectives. To test hypothesized associations between the ABO blood group (ABO-bg) system and the pathological features of prostate cancer (PCa).
Material and methods. Between January 2013 and September 2019, 1173 patients underwent radical prostatectomy. Associations between ABO-bg levels and pathological features were evaluated using statistical methods.
Results. Overall, 1149 consecutive patients were evaluated using the ABO-bg system, which was represented by O-bg (42.8%) and A-bg (41.3%), followed by B-bg (11.1%) and AB-bg (4.8%). Only positive surgical margins (PSMs) was correlated with ABO-bg (Pearson correlation coefficient, r = 0.071; p = 0.017), and the risk was increased in group-O (odds ratio [OR], 1.497; 95% confidence interval, 1.149–1.950; p = 0.003) versus non–O-bg. In clinical and pathological models, O-bg was at increased risk of PSM after the adjustment for prostate-specific antigen, percentage of biopsy-positive cores, and high surgical volume (adjusted OR, 1.546; 95% confidence interval, 1.180–2.026; p = 0.002); however, the adjusted OR did not change after the adjustment for tumor load and stage as well as high surgical volume.
Conclusions. In clinical PCa, the risk of PSM was higher in O-bg versus non–O-bg patients after the adjustment for standard predictors. Confirmatory studies are needed to confirm the association between ABO-bg and unfavorable PCa features. |
| first_indexed | 2024-04-10T20:47:55Z |
| format | Article |
| id | doaj.art-5809d0fac62f4126ac2e50b431f12ad5 |
| institution | Directory Open Access Journal |
| issn | 1661-7649 |
| language | English |
| last_indexed | 2024-04-10T20:47:55Z |
| publishDate | 2022-12-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Current Urology |
| spelling | doaj.art-5809d0fac62f4126ac2e50b431f12ad52023-01-24T00:57:27ZengWolters Kluwer HealthCurrent Urology1661-76492022-12-0116425626110.1097/CU9.0000000000000146202212000-00010Association between ABO blood group and unfavorable prostate cancer features after radical prostatectomy: Retrospective study of 1149 patientsAntonio Benito Porcaro0Nelia Amigoni1Riccardo Rizzetto2Filippo Migliorini3Alessandro Tafuri4Pierluigi Piccoli5Leone Tiso6Mario De Michele7Alberto Bianchi8Sebastian Gallina9Paola Irene Ornaghi10Rossella Orlando11Francesco Cianflone12Alessandra Gozzo13Stefano Zecchini Antoniolli14Vincenzo Lacola15Matteo Brunelli16Maria Angela Cerruto17Walter Artibani18Alessandro Antonelli19a Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italya Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italya Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italya Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italya Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italyc Department of Transfusion Medicine, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italya Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italya Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italya Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italya Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italya Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italya Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italya Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italya Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italya Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italya Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italyd Department of Pathology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italya Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italya Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italya Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, ItalyAbstract. Objectives. To test hypothesized associations between the ABO blood group (ABO-bg) system and the pathological features of prostate cancer (PCa). Material and methods. Between January 2013 and September 2019, 1173 patients underwent radical prostatectomy. Associations between ABO-bg levels and pathological features were evaluated using statistical methods. Results. Overall, 1149 consecutive patients were evaluated using the ABO-bg system, which was represented by O-bg (42.8%) and A-bg (41.3%), followed by B-bg (11.1%) and AB-bg (4.8%). Only positive surgical margins (PSMs) was correlated with ABO-bg (Pearson correlation coefficient, r = 0.071; p = 0.017), and the risk was increased in group-O (odds ratio [OR], 1.497; 95% confidence interval, 1.149–1.950; p = 0.003) versus non–O-bg. In clinical and pathological models, O-bg was at increased risk of PSM after the adjustment for prostate-specific antigen, percentage of biopsy-positive cores, and high surgical volume (adjusted OR, 1.546; 95% confidence interval, 1.180–2.026; p = 0.002); however, the adjusted OR did not change after the adjustment for tumor load and stage as well as high surgical volume. Conclusions. In clinical PCa, the risk of PSM was higher in O-bg versus non–O-bg patients after the adjustment for standard predictors. Confirmatory studies are needed to confirm the association between ABO-bg and unfavorable PCa features.http://journals.lww.com/10.1097/CU9.0000000000000146 |
| spellingShingle | Antonio Benito Porcaro Nelia Amigoni Riccardo Rizzetto Filippo Migliorini Alessandro Tafuri Pierluigi Piccoli Leone Tiso Mario De Michele Alberto Bianchi Sebastian Gallina Paola Irene Ornaghi Rossella Orlando Francesco Cianflone Alessandra Gozzo Stefano Zecchini Antoniolli Vincenzo Lacola Matteo Brunelli Maria Angela Cerruto Walter Artibani Alessandro Antonelli Association between ABO blood group and unfavorable prostate cancer features after radical prostatectomy: Retrospective study of 1149 patients Current Urology |
| title | Association between ABO blood group and unfavorable prostate cancer features after radical prostatectomy: Retrospective study of 1149 patients |
| title_full | Association between ABO blood group and unfavorable prostate cancer features after radical prostatectomy: Retrospective study of 1149 patients |
| title_fullStr | Association between ABO blood group and unfavorable prostate cancer features after radical prostatectomy: Retrospective study of 1149 patients |
| title_full_unstemmed | Association between ABO blood group and unfavorable prostate cancer features after radical prostatectomy: Retrospective study of 1149 patients |
| title_short | Association between ABO blood group and unfavorable prostate cancer features after radical prostatectomy: Retrospective study of 1149 patients |
| title_sort | association between abo blood group and unfavorable prostate cancer features after radical prostatectomy retrospective study of 1149 patients |
| url | http://journals.lww.com/10.1097/CU9.0000000000000146 |
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