Global serum profiling: an opportunity for earlier cancer detection
Abstract The advances in cancer research achieved in the last 50 years have been remarkable and have provided a deeper knowledge of this disease in many of its conceptual and biochemical aspects. From viewing a tumor as a ‘simple’ aggregate of mutant cells and focusing on detecting key cell changes...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-023-02786-y |
| _version_ | 1797555664401203200 |
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| author | Alexandra Sala James M. Cameron Paul M. Brennan Emma J. Crosbie Tom Curran Ewan Gray Pierre Martin-Hirsch David S. Palmer Ihtesham U. Rehman Nicholas J. W. Rattray Matthew J. Baker |
| author_facet | Alexandra Sala James M. Cameron Paul M. Brennan Emma J. Crosbie Tom Curran Ewan Gray Pierre Martin-Hirsch David S. Palmer Ihtesham U. Rehman Nicholas J. W. Rattray Matthew J. Baker |
| author_sort | Alexandra Sala |
| collection | DOAJ |
| description | Abstract The advances in cancer research achieved in the last 50 years have been remarkable and have provided a deeper knowledge of this disease in many of its conceptual and biochemical aspects. From viewing a tumor as a ‘simple’ aggregate of mutant cells and focusing on detecting key cell changes leading to the tumorigenesis, the understanding of cancer has broadened to consider it as a complex organ interacting with its close and far surroundings through tumor and non-tumor cells, metabolic mechanisms, and immune processes. Metabolism and the immune system have been linked to tumorigenesis and malignancy progression along with cancer-specific genetic mutations. However, most technologies developed to overcome the barriers to earlier detection are focused solely on genetic information. The concept of cancer as a complex organ has led to research on other analytical techniques, with the quest of finding a more sensitive and cost-effective comprehensive approach. Furthermore, artificial intelligence has gained broader consensus in the oncology community as a powerful tool with the potential to revolutionize cancer diagnosis for physicians. We herein explore the relevance of the concept of cancer as a complex organ interacting with the bodily surroundings, and focus on promising emerging technologies seeking to diagnose cancer earlier, such as liquid biopsies. We highlight the importance of a comprehensive approach to encompass all the tumor and non-tumor derived information salient to earlier cancer detection. |
| first_indexed | 2024-03-10T16:50:43Z |
| format | Article |
| id | doaj.art-580b7a572fd543ac8ff0b8e90d364bf2 |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-03-10T16:50:43Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-580b7a572fd543ac8ff0b8e90d364bf22023-11-20T11:18:15ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662023-08-0142111510.1186/s13046-023-02786-yGlobal serum profiling: an opportunity for earlier cancer detectionAlexandra Sala0James M. Cameron1Paul M. Brennan2Emma J. Crosbie3Tom Curran4Ewan Gray5Pierre Martin-Hirsch6David S. Palmer7Ihtesham U. Rehman8Nicholas J. W. Rattray9Matthew J. Baker10Dxcover LimitedDxcover LimitedTranslational Neurosurgery, Department of Clinical Neurosciences, Royal Infirmary of EdinburghDivision of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of ManchesterChildren’s Mercy Research Institute, Children’s Mercy Kansas CityIndependent Health Economics ConsultantGynecological Oncology, Clinical Research Facility, Lancashire Teaching HospitalsDxcover LimitedSchool of Medicine, Faculty of Clinical and Biomedical Sciences, University of Central LancashireStrathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of StrathclydeDxcover LimitedAbstract The advances in cancer research achieved in the last 50 years have been remarkable and have provided a deeper knowledge of this disease in many of its conceptual and biochemical aspects. From viewing a tumor as a ‘simple’ aggregate of mutant cells and focusing on detecting key cell changes leading to the tumorigenesis, the understanding of cancer has broadened to consider it as a complex organ interacting with its close and far surroundings through tumor and non-tumor cells, metabolic mechanisms, and immune processes. Metabolism and the immune system have been linked to tumorigenesis and malignancy progression along with cancer-specific genetic mutations. However, most technologies developed to overcome the barriers to earlier detection are focused solely on genetic information. The concept of cancer as a complex organ has led to research on other analytical techniques, with the quest of finding a more sensitive and cost-effective comprehensive approach. Furthermore, artificial intelligence has gained broader consensus in the oncology community as a powerful tool with the potential to revolutionize cancer diagnosis for physicians. We herein explore the relevance of the concept of cancer as a complex organ interacting with the bodily surroundings, and focus on promising emerging technologies seeking to diagnose cancer earlier, such as liquid biopsies. We highlight the importance of a comprehensive approach to encompass all the tumor and non-tumor derived information salient to earlier cancer detection.https://doi.org/10.1186/s13046-023-02786-yLiquid biopsyBlood serumCancer detectionDiagnosisTumorigenesisMetabolism |
| spellingShingle | Alexandra Sala James M. Cameron Paul M. Brennan Emma J. Crosbie Tom Curran Ewan Gray Pierre Martin-Hirsch David S. Palmer Ihtesham U. Rehman Nicholas J. W. Rattray Matthew J. Baker Global serum profiling: an opportunity for earlier cancer detection Journal of Experimental & Clinical Cancer Research Liquid biopsy Blood serum Cancer detection Diagnosis Tumorigenesis Metabolism |
| title | Global serum profiling: an opportunity for earlier cancer detection |
| title_full | Global serum profiling: an opportunity for earlier cancer detection |
| title_fullStr | Global serum profiling: an opportunity for earlier cancer detection |
| title_full_unstemmed | Global serum profiling: an opportunity for earlier cancer detection |
| title_short | Global serum profiling: an opportunity for earlier cancer detection |
| title_sort | global serum profiling an opportunity for earlier cancer detection |
| topic | Liquid biopsy Blood serum Cancer detection Diagnosis Tumorigenesis Metabolism |
| url | https://doi.org/10.1186/s13046-023-02786-y |
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