Oxytocin Receptor Polymorphism Decreases Midline Neural Activations to Social Stimuli in Anorexia Nervosa
Oxytocin is a neurotransmitter related to both feeding and social behavior; anorexia nervosa is a psychiatric illness defined by reduced food intake, weight loss, and problems in social perceptions. Oxytocin receptor single nucleotide polymorphisms rs2254298 or rs53576 and neural responses to social...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyg.2018.02183/full |
| _version_ | 1818274632755576832 |
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| author | Margarita Sala Kihwan Han Summer Acevedo Daniel C. Krawczyk Daniel C. Krawczyk Carrie J. McAdams |
| author_facet | Margarita Sala Kihwan Han Summer Acevedo Daniel C. Krawczyk Daniel C. Krawczyk Carrie J. McAdams |
| author_sort | Margarita Sala |
| collection | DOAJ |
| description | Oxytocin is a neurotransmitter related to both feeding and social behavior; anorexia nervosa is a psychiatric illness defined by reduced food intake, weight loss, and problems in social perceptions. Oxytocin receptor single nucleotide polymorphisms rs2254298 or rs53576 and neural responses to social stimuli were evaluated in adult women with or recovered from anorexia nervosa using functional magnetic resonance imaging. Carriers of the A allele for OXTR rs2254298 (2 AA and 10 AG) showed significantly reduced activation of portions of the posterior cingulate cortex and medial prefrontal cortex for social stimuli as well as greater negative connectivity between the posterior cingulate and the occipital lobe relative to the GG subjects for rs2254298. Differences in the other OXTR SNP, rs53576, did not result in detectable neural differences in either whole brain or region of interest analyses. Development of a mechanistic, biological model of how social behavior is impacted by mental illness requires linking genes to functional brain activations in disease. This pilot study suggests that in anorexia nervosa, differences related to OXTR SNP rs2254298 may alter neural responses to social stimuli and disrupt the engagement and disengagement of the default mode network. |
| first_indexed | 2024-12-12T22:16:57Z |
| format | Article |
| id | doaj.art-580c53bbd85d42b1b1a70a676557b1f4 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-12-12T22:16:57Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-580c53bbd85d42b1b1a70a676557b1f42022-12-22T00:10:02ZengFrontiers Media S.A.Frontiers in Psychology1664-10782018-11-01910.3389/fpsyg.2018.02183418694Oxytocin Receptor Polymorphism Decreases Midline Neural Activations to Social Stimuli in Anorexia NervosaMargarita Sala0Kihwan Han1Summer Acevedo2Daniel C. Krawczyk3Daniel C. Krawczyk4Carrie J. McAdams5Department of Psychology, Southern Methodist University, Dallas, TX, United StatesCenter for Brain Health, University of Texas at Dallas, Dallas, TX, United StatesDepartment of Psychiatry, University of Texas at Southwestern Medical School, Dallas, TX, United StatesCenter for Brain Health, University of Texas at Dallas, Dallas, TX, United StatesDepartment of Psychiatry, University of Texas at Southwestern Medical School, Dallas, TX, United StatesDepartment of Psychiatry, University of Texas at Southwestern Medical School, Dallas, TX, United StatesOxytocin is a neurotransmitter related to both feeding and social behavior; anorexia nervosa is a psychiatric illness defined by reduced food intake, weight loss, and problems in social perceptions. Oxytocin receptor single nucleotide polymorphisms rs2254298 or rs53576 and neural responses to social stimuli were evaluated in adult women with or recovered from anorexia nervosa using functional magnetic resonance imaging. Carriers of the A allele for OXTR rs2254298 (2 AA and 10 AG) showed significantly reduced activation of portions of the posterior cingulate cortex and medial prefrontal cortex for social stimuli as well as greater negative connectivity between the posterior cingulate and the occipital lobe relative to the GG subjects for rs2254298. Differences in the other OXTR SNP, rs53576, did not result in detectable neural differences in either whole brain or region of interest analyses. Development of a mechanistic, biological model of how social behavior is impacted by mental illness requires linking genes to functional brain activations in disease. This pilot study suggests that in anorexia nervosa, differences related to OXTR SNP rs2254298 may alter neural responses to social stimuli and disrupt the engagement and disengagement of the default mode network.https://www.frontiersin.org/article/10.3389/fpsyg.2018.02183/fullsocial cognitionfMRIeating disordersneuroimagingself-perceptiondepression |
| spellingShingle | Margarita Sala Kihwan Han Summer Acevedo Daniel C. Krawczyk Daniel C. Krawczyk Carrie J. McAdams Oxytocin Receptor Polymorphism Decreases Midline Neural Activations to Social Stimuli in Anorexia Nervosa Frontiers in Psychology social cognition fMRI eating disorders neuroimaging self-perception depression |
| title | Oxytocin Receptor Polymorphism Decreases Midline Neural Activations to Social Stimuli in Anorexia Nervosa |
| title_full | Oxytocin Receptor Polymorphism Decreases Midline Neural Activations to Social Stimuli in Anorexia Nervosa |
| title_fullStr | Oxytocin Receptor Polymorphism Decreases Midline Neural Activations to Social Stimuli in Anorexia Nervosa |
| title_full_unstemmed | Oxytocin Receptor Polymorphism Decreases Midline Neural Activations to Social Stimuli in Anorexia Nervosa |
| title_short | Oxytocin Receptor Polymorphism Decreases Midline Neural Activations to Social Stimuli in Anorexia Nervosa |
| title_sort | oxytocin receptor polymorphism decreases midline neural activations to social stimuli in anorexia nervosa |
| topic | social cognition fMRI eating disorders neuroimaging self-perception depression |
| url | https://www.frontiersin.org/article/10.3389/fpsyg.2018.02183/full |
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