Regulation of Cancer Stem Cells and Epithelial-Mesenchymal Transition by CTNNAL1 in Lung Cancer and Glioblastoma
CTNNAL1 is a protein known to be involved in cell–cell adhesion and cell adhesion. Alterations in the expression or function of CTNNAL1 have been reported to contribute to the development and progression of various types of cancer. In breast cancer, CTNNAL1 has been reported as a cancer suppressor g...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/11/5/1462 |
| _version_ | 1797600922055999488 |
|---|---|
| author | Yeon-Jee Kahm Uhee Jung Rae-Kwon Kim |
| author_facet | Yeon-Jee Kahm Uhee Jung Rae-Kwon Kim |
| author_sort | Yeon-Jee Kahm |
| collection | DOAJ |
| description | CTNNAL1 is a protein known to be involved in cell–cell adhesion and cell adhesion. Alterations in the expression or function of CTNNAL1 have been reported to contribute to the development and progression of various types of cancer. In breast cancer, CTNNAL1 has been reported as a cancer suppressor gene, and in melanoma and lung cancer, it has been reported as a cancer driver gene. However, due to a lack of research, its function remains unclear. In this study, it is shown that CTNNAL1 regulates cancer stem cells (CSCs) in lung cancer and glioblastoma and modulates their migration and invasion abilities. CSCs are known to play an important role in the malignant transformation of cancer. They have the ability to resist chemotherapeutic drugs and irradiation, which is a known obstacle to cancer treatment. We found that CTNNAL1 regulates the ability to resist irradiation. In addition, we observed that CTNNAL1 regulates the ability of cells to migrate and invade, a key feature of the epithelial to mesenchymal transition phenomenon associated with cancer metastasis. CTNNAL1 was also involved in the secretion of C–C motif chemokine ligand 2 (CCL2), one of the chemokines. CCL2 plays a role in the recruitment of immune cells to the tumor microenvironment, but in cancer, it is known to influence malignancy and metastasis. CTNNAL1 may be a novel target for treating lung CSCs and glioma stem cells and may be used as a marker of malignancy. |
| first_indexed | 2024-03-11T03:54:41Z |
| format | Article |
| id | doaj.art-580f503919214c35a564595a089e8ae8 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T03:54:41Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-580f503919214c35a564595a089e8ae82023-11-18T00:37:29ZengMDPI AGBiomedicines2227-90592023-05-01115146210.3390/biomedicines11051462Regulation of Cancer Stem Cells and Epithelial-Mesenchymal Transition by CTNNAL1 in Lung Cancer and GlioblastomaYeon-Jee Kahm0Uhee Jung1Rae-Kwon Kim2Department of Radiation Biology, Environmental Safety Technology Research Division, Korea Atomic Energy Research Institute, Yuseong-Gu, Daejeon 34057, Republic of KoreaDepartment of Radiation Biology, Environmental Safety Technology Research Division, Korea Atomic Energy Research Institute, Yuseong-Gu, Daejeon 34057, Republic of KoreaDepartment of Radiation Biology, Environmental Safety Technology Research Division, Korea Atomic Energy Research Institute, Yuseong-Gu, Daejeon 34057, Republic of KoreaCTNNAL1 is a protein known to be involved in cell–cell adhesion and cell adhesion. Alterations in the expression or function of CTNNAL1 have been reported to contribute to the development and progression of various types of cancer. In breast cancer, CTNNAL1 has been reported as a cancer suppressor gene, and in melanoma and lung cancer, it has been reported as a cancer driver gene. However, due to a lack of research, its function remains unclear. In this study, it is shown that CTNNAL1 regulates cancer stem cells (CSCs) in lung cancer and glioblastoma and modulates their migration and invasion abilities. CSCs are known to play an important role in the malignant transformation of cancer. They have the ability to resist chemotherapeutic drugs and irradiation, which is a known obstacle to cancer treatment. We found that CTNNAL1 regulates the ability to resist irradiation. In addition, we observed that CTNNAL1 regulates the ability of cells to migrate and invade, a key feature of the epithelial to mesenchymal transition phenomenon associated with cancer metastasis. CTNNAL1 was also involved in the secretion of C–C motif chemokine ligand 2 (CCL2), one of the chemokines. CCL2 plays a role in the recruitment of immune cells to the tumor microenvironment, but in cancer, it is known to influence malignancy and metastasis. CTNNAL1 may be a novel target for treating lung CSCs and glioma stem cells and may be used as a marker of malignancy.https://www.mdpi.com/2227-9059/11/5/1462CTNNAL1catenin alpha-like 1cancer stem cellsepithelial-mesenchymal transitionCCL2 |
| spellingShingle | Yeon-Jee Kahm Uhee Jung Rae-Kwon Kim Regulation of Cancer Stem Cells and Epithelial-Mesenchymal Transition by CTNNAL1 in Lung Cancer and Glioblastoma Biomedicines CTNNAL1 catenin alpha-like 1 cancer stem cells epithelial-mesenchymal transition CCL2 |
| title | Regulation of Cancer Stem Cells and Epithelial-Mesenchymal Transition by CTNNAL1 in Lung Cancer and Glioblastoma |
| title_full | Regulation of Cancer Stem Cells and Epithelial-Mesenchymal Transition by CTNNAL1 in Lung Cancer and Glioblastoma |
| title_fullStr | Regulation of Cancer Stem Cells and Epithelial-Mesenchymal Transition by CTNNAL1 in Lung Cancer and Glioblastoma |
| title_full_unstemmed | Regulation of Cancer Stem Cells and Epithelial-Mesenchymal Transition by CTNNAL1 in Lung Cancer and Glioblastoma |
| title_short | Regulation of Cancer Stem Cells and Epithelial-Mesenchymal Transition by CTNNAL1 in Lung Cancer and Glioblastoma |
| title_sort | regulation of cancer stem cells and epithelial mesenchymal transition by ctnnal1 in lung cancer and glioblastoma |
| topic | CTNNAL1 catenin alpha-like 1 cancer stem cells epithelial-mesenchymal transition CCL2 |
| url | https://www.mdpi.com/2227-9059/11/5/1462 |
| work_keys_str_mv | AT yeonjeekahm regulationofcancerstemcellsandepithelialmesenchymaltransitionbyctnnal1inlungcancerandglioblastoma AT uheejung regulationofcancerstemcellsandepithelialmesenchymaltransitionbyctnnal1inlungcancerandglioblastoma AT raekwonkim regulationofcancerstemcellsandepithelialmesenchymaltransitionbyctnnal1inlungcancerandglioblastoma |