Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells

Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells

Abstract The network of thymic stromal cells provides essential niches with unique molecular cues controlling T cell development and selection. Recent single-cell RNA sequencing studies have uncovered previously unappreciated transcriptional heterogeneity among thymic epithelial cells (TEC). However...

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Bibliographic Details
Main Authors: Fabian Klein, Clara Veiga-Villauriz, Anastasiya Börsch, Stefano Maio, Sam Palmer, Fatima Dhalla, Adam E. Handel, Saulius Zuklys, Irene Calvo-Asensio, Lucas Musette, Mary E. Deadman, Andrea J. White, Beth Lucas, Graham Anderson, Georg A. Holländer
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39722-9

Internet

https://doi.org/10.1038/s41467-023-39722-9

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