Cyclophosphamide-induced hepatotoxicity in wistar rats: The modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemical
Background: Gallic acid (GA) is an endogenous plant phenol known to have antioxidant, free radical scavenging ability, anti-inflammatory, anti-cancer, and anti-fungal properties. The aim of this study was to assess the protective effect of GA on cyclophosphamide (CPA)-induced hepatotoxicity in male...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | International Journal of Preventive Medicine |
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| Online Access: | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2016;volume=7;issue=1;spage=51;epage=51;aulast=Oyagbemi |
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| author | Ademola Adetokunbo Oyagbemi Olutayo Temidayo Omobowale Ebunoluwa Rachael Asenuga Akinrinde Stephen Akinleye Rachael Omolola Ogunsanwo Adebowale Bernard Saba Ademola Adetokunbo Oyagbemi Olutayo Temidayo Omobowale Ebunoluwa Rachael Asenuga Akinrinde Stephen Akinleye Rachael Omolola Ogunsanwo Adebowale Bernard Saba |
| author_facet | Ademola Adetokunbo Oyagbemi Olutayo Temidayo Omobowale Ebunoluwa Rachael Asenuga Akinrinde Stephen Akinleye Rachael Omolola Ogunsanwo Adebowale Bernard Saba Ademola Adetokunbo Oyagbemi Olutayo Temidayo Omobowale Ebunoluwa Rachael Asenuga Akinrinde Stephen Akinleye Rachael Omolola Ogunsanwo Adebowale Bernard Saba |
| author_sort | Ademola Adetokunbo Oyagbemi |
| collection | DOAJ |
| description | Background: Gallic acid (GA) is an endogenous plant phenol known to have antioxidant, free radical scavenging ability, anti-inflammatory, anti-cancer, and anti-fungal properties. The aim of this study was to assess the protective effect of GA on cyclophosphamide (CPA)-induced hepatotoxicity in male Wistar rats.
Methods: Sixty rats were grouped into six groups of 10 rats per group. Group 1 received distilled water. Group 2 received CPA at 200 mg/kg single dose intraperitoneally on day 1. Groups 3 and 4 received a single dose of CPA (200 mg/kg) intraperitoneally on day 1 and then were treated with GA at 60 and 120 mg/kg body weight for 14 days, respectively. Rats in Groups 5 and 6 only received GA at 60 and 120 mg/kg body weight for 14 days, respectively. GA was administered orally.
Results: CPA induced hepatic damage as indicated by significant elevation (P < 0.05) in aspartate aminotransferase, organ weight, and evidence by the histological study. CPA also induced hepatic oxidative stress as indicated by significant elevation (P < 0.05) in malondialdehyde content, hydrogen peroxide (H 2 O 2 ) generation, nitrite level, and the level of glutathione (GSH) peroxidase crashed in the CPA-treated group. GA enhanced the antioxidant defense system as indicated by significant elevation (P < 0.05) in GSH level, catalase activity, and GSH-S-transferase activity.
Conclusions: Taken together, the result of this present study shows that GA has a protective effect on CPA-induced hepatotoxicity. |
| first_indexed | 2024-04-13T09:31:05Z |
| format | Article |
| id | doaj.art-58115b6afc434ad1b746ef699ea409b3 |
| institution | Directory Open Access Journal |
| issn | 2008-7802 2008-8213 |
| language | English |
| last_indexed | 2024-04-13T09:31:05Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Preventive Medicine |
| spelling | doaj.art-58115b6afc434ad1b746ef699ea409b32022-12-22T02:52:14ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132016-01-0171515110.4103/2008-7802.177898Cyclophosphamide-induced hepatotoxicity in wistar rats: The modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemicalAdemola Adetokunbo OyagbemiOlutayo Temidayo OmobowaleEbunoluwa Rachael AsenugaAkinrinde Stephen AkinleyeRachael Omolola OgunsanwoAdebowale Bernard SabaAdemola Adetokunbo OyagbemiOlutayo Temidayo OmobowaleEbunoluwa Rachael AsenugaAkinrinde Stephen AkinleyeRachael Omolola OgunsanwoAdebowale Bernard SabaBackground: Gallic acid (GA) is an endogenous plant phenol known to have antioxidant, free radical scavenging ability, anti-inflammatory, anti-cancer, and anti-fungal properties. The aim of this study was to assess the protective effect of GA on cyclophosphamide (CPA)-induced hepatotoxicity in male Wistar rats. Methods: Sixty rats were grouped into six groups of 10 rats per group. Group 1 received distilled water. Group 2 received CPA at 200 mg/kg single dose intraperitoneally on day 1. Groups 3 and 4 received a single dose of CPA (200 mg/kg) intraperitoneally on day 1 and then were treated with GA at 60 and 120 mg/kg body weight for 14 days, respectively. Rats in Groups 5 and 6 only received GA at 60 and 120 mg/kg body weight for 14 days, respectively. GA was administered orally. Results: CPA induced hepatic damage as indicated by significant elevation (P < 0.05) in aspartate aminotransferase, organ weight, and evidence by the histological study. CPA also induced hepatic oxidative stress as indicated by significant elevation (P < 0.05) in malondialdehyde content, hydrogen peroxide (H 2 O 2 ) generation, nitrite level, and the level of glutathione (GSH) peroxidase crashed in the CPA-treated group. GA enhanced the antioxidant defense system as indicated by significant elevation (P < 0.05) in GSH level, catalase activity, and GSH-S-transferase activity. Conclusions: Taken together, the result of this present study shows that GA has a protective effect on CPA-induced hepatotoxicity.http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2016;volume=7;issue=1;spage=51;epage=51;aulast=OyagbemiAntioxidantcyclophosphamidegallic acidhepatotoxicityoxidative stress |
| spellingShingle | Ademola Adetokunbo Oyagbemi Olutayo Temidayo Omobowale Ebunoluwa Rachael Asenuga Akinrinde Stephen Akinleye Rachael Omolola Ogunsanwo Adebowale Bernard Saba Ademola Adetokunbo Oyagbemi Olutayo Temidayo Omobowale Ebunoluwa Rachael Asenuga Akinrinde Stephen Akinleye Rachael Omolola Ogunsanwo Adebowale Bernard Saba Cyclophosphamide-induced hepatotoxicity in wistar rats: The modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemical International Journal of Preventive Medicine Antioxidant cyclophosphamide gallic acid hepatotoxicity oxidative stress |
| title | Cyclophosphamide-induced hepatotoxicity in wistar rats: The modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemical |
| title_full | Cyclophosphamide-induced hepatotoxicity in wistar rats: The modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemical |
| title_fullStr | Cyclophosphamide-induced hepatotoxicity in wistar rats: The modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemical |
| title_full_unstemmed | Cyclophosphamide-induced hepatotoxicity in wistar rats: The modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemical |
| title_short | Cyclophosphamide-induced hepatotoxicity in wistar rats: The modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemical |
| title_sort | cyclophosphamide induced hepatotoxicity in wistar rats the modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemical |
| topic | Antioxidant cyclophosphamide gallic acid hepatotoxicity oxidative stress |
| url | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2016;volume=7;issue=1;spage=51;epage=51;aulast=Oyagbemi |
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