Effects of Thermal Relaxation on Temperature Elevation in Ex Vivo Tissues During High Intensity Focused Ultrasound
The introduction of thermal relaxation makes non-Fourier heat transfer more effective than Pennes equation to reflect rapid bio-heat transferring during HIFU, however, the contribution of thermal relaxation in specific tissues needs to be further clarified. In this study, we first measured the therm...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IEEE
2020-01-01
|
| Series: | IEEE Access |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/9269383/ |
| _version_ | 1818579352015601664 |
|---|---|
| author | Chenghai Li Siyao Chen Qi Wang Hao Li Shuai Xiao Faqi Li |
| author_facet | Chenghai Li Siyao Chen Qi Wang Hao Li Shuai Xiao Faqi Li |
| author_sort | Chenghai Li |
| collection | DOAJ |
| description | The introduction of thermal relaxation makes non-Fourier heat transfer more effective than Pennes equation to reflect rapid bio-heat transferring during HIFU, however, the contribution of thermal relaxation in specific tissues needs to be further clarified. In this study, we first measured the thermal relaxation times of porcine muscle and porcine fat. Combining with experimental measurements, the effects of thermal relaxation on temperature elevation in the tissues were investigated by using Pennes equation, thermal wave model of bio-heat transfer (TWMBT) and dual phase-lag (DPL) bio-heat transfer. Results showed that: a) The thermal relaxation times of porcine muscle and porcine fat are experimentally determined as 5.71± 0.11 s and 5.02± 0.06 s, respectively. b) In the absence of cavitation, DPL bio-heat transfer is more accurate to predict the temperature elevation at the focus and 2 mm from the focus than Pennes equation and TWMBT. Particularly, comparing with the reported of bologna (16 s) used in most of the theoretical analysis, the utilization of the measured thermal relaxation time for a specific tissue in DPL bio-heat transfer is more effective in predicting the temperature elevation during HIFU. c) Acoustic cavitation and nonlinear propagation is easier to happen in fat, under which all bio-heat transfer models are failed to forecast the temperature elevation induced by HIFU. The results demonstrate that different tissues have different thermal relaxation, DPL bio-heat transfer with the measured thermal relaxation times of specific tissues can accurately predict the temperature elevation during HIFU without cavitation. |
| first_indexed | 2024-12-16T07:00:20Z |
| format | Article |
| id | doaj.art-5811bdd774934e7780a492e3b51f3ae6 |
| institution | Directory Open Access Journal |
| issn | 2169-3536 |
| language | English |
| last_indexed | 2024-12-16T07:00:20Z |
| publishDate | 2020-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Access |
| spelling | doaj.art-5811bdd774934e7780a492e3b51f3ae62022-12-21T22:40:11ZengIEEEIEEE Access2169-35362020-01-01821201321202110.1109/ACCESS.2020.30401029269383Effects of Thermal Relaxation on Temperature Elevation in Ex Vivo Tissues During High Intensity Focused UltrasoundChenghai Li0https://orcid.org/0000-0002-8674-1621Siyao Chen1https://orcid.org/0000-0002-4291-8181Qi Wang2Hao Li3https://orcid.org/0000-0001-7294-2337Shuai Xiao4https://orcid.org/0000-0003-4688-2080Faqi Li5State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaState Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, ChinaThe introduction of thermal relaxation makes non-Fourier heat transfer more effective than Pennes equation to reflect rapid bio-heat transferring during HIFU, however, the contribution of thermal relaxation in specific tissues needs to be further clarified. In this study, we first measured the thermal relaxation times of porcine muscle and porcine fat. Combining with experimental measurements, the effects of thermal relaxation on temperature elevation in the tissues were investigated by using Pennes equation, thermal wave model of bio-heat transfer (TWMBT) and dual phase-lag (DPL) bio-heat transfer. Results showed that: a) The thermal relaxation times of porcine muscle and porcine fat are experimentally determined as 5.71± 0.11 s and 5.02± 0.06 s, respectively. b) In the absence of cavitation, DPL bio-heat transfer is more accurate to predict the temperature elevation at the focus and 2 mm from the focus than Pennes equation and TWMBT. Particularly, comparing with the reported of bologna (16 s) used in most of the theoretical analysis, the utilization of the measured thermal relaxation time for a specific tissue in DPL bio-heat transfer is more effective in predicting the temperature elevation during HIFU. c) Acoustic cavitation and nonlinear propagation is easier to happen in fat, under which all bio-heat transfer models are failed to forecast the temperature elevation induced by HIFU. The results demonstrate that different tissues have different thermal relaxation, DPL bio-heat transfer with the measured thermal relaxation times of specific tissues can accurately predict the temperature elevation during HIFU without cavitation.https://ieeexplore.ieee.org/document/9269383/Bio-heat transferthermal relaxationhigh intensity focused ultrasound |
| spellingShingle | Chenghai Li Siyao Chen Qi Wang Hao Li Shuai Xiao Faqi Li Effects of Thermal Relaxation on Temperature Elevation in Ex Vivo Tissues During High Intensity Focused Ultrasound IEEE Access Bio-heat transfer thermal relaxation high intensity focused ultrasound |
| title | Effects of Thermal Relaxation on Temperature Elevation in Ex Vivo Tissues During High Intensity Focused Ultrasound |
| title_full | Effects of Thermal Relaxation on Temperature Elevation in Ex Vivo Tissues During High Intensity Focused Ultrasound |
| title_fullStr | Effects of Thermal Relaxation on Temperature Elevation in Ex Vivo Tissues During High Intensity Focused Ultrasound |
| title_full_unstemmed | Effects of Thermal Relaxation on Temperature Elevation in Ex Vivo Tissues During High Intensity Focused Ultrasound |
| title_short | Effects of Thermal Relaxation on Temperature Elevation in Ex Vivo Tissues During High Intensity Focused Ultrasound |
| title_sort | effects of thermal relaxation on temperature elevation in ex vivo tissues during high intensity focused ultrasound |
| topic | Bio-heat transfer thermal relaxation high intensity focused ultrasound |
| url | https://ieeexplore.ieee.org/document/9269383/ |
| work_keys_str_mv | AT chenghaili effectsofthermalrelaxationontemperatureelevationinexvivotissuesduringhighintensityfocusedultrasound AT siyaochen effectsofthermalrelaxationontemperatureelevationinexvivotissuesduringhighintensityfocusedultrasound AT qiwang effectsofthermalrelaxationontemperatureelevationinexvivotissuesduringhighintensityfocusedultrasound AT haoli effectsofthermalrelaxationontemperatureelevationinexvivotissuesduringhighintensityfocusedultrasound AT shuaixiao effectsofthermalrelaxationontemperatureelevationinexvivotissuesduringhighintensityfocusedultrasound AT faqili effectsofthermalrelaxationontemperatureelevationinexvivotissuesduringhighintensityfocusedultrasound |