Zero-Biased Photoelectrochemical Detection of Cardiac Biomarker Myoglobin Based on CdSeS/ZnS Quantum Dots and Barium Titanate Perovskite
Cardiovascular diseases are considered one of the leading causes of premature mortality of patients worldwide. Therefore, rapid diagnosis of these diseases is crucial to ensure the patient’s survival. During a heart attack or severe muscle damage, myoglobin is rapidly released in the body to constit...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/15/4778 |
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| author | Fernanda M. R. Lima Alan S. de Menezes Adeilton P. Maciel Francisco S. M. Sinfrônio Lauro T. Kubota Flávio S. Damos Rita C. S. Luz |
| author_facet | Fernanda M. R. Lima Alan S. de Menezes Adeilton P. Maciel Francisco S. M. Sinfrônio Lauro T. Kubota Flávio S. Damos Rita C. S. Luz |
| author_sort | Fernanda M. R. Lima |
| collection | DOAJ |
| description | Cardiovascular diseases are considered one of the leading causes of premature mortality of patients worldwide. Therefore, rapid diagnosis of these diseases is crucial to ensure the patient’s survival. During a heart attack or severe muscle damage, myoglobin is rapidly released in the body to constitute itself as a precise biomarker of acute myocardial infarction. Thus, we described the photoelectrochemical immunosensor development to detect myoglobin. It was based on fluorine-doped tin oxide modified with CdSeS/ZnSe quantum dots and barium titanate (BTO), designated as CdSeS/ZnSQDS/BTO. It was characterized by scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDX), transmission electron microscopy (TEM), X-ray diffraction (XRD), electrochemical impedance spectroscopy (EIS), and amperometry. The anodic photocurrent at the potential of 0 V (vs. Ag/AgCl) and pH 7.4 was found linearly related to the myoglobin (Mb) concentration from 0.01 to 1000 ng mL<sup>−1</sup>. Furthermore, the immunosensor showed an average recovery rate of 95.7–110.7% for the determination of myoglobin. |
| first_indexed | 2024-03-09T10:06:28Z |
| format | Article |
| id | doaj.art-5813d1ef96d44a6eb298757b944d4972 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T10:06:28Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5813d1ef96d44a6eb298757b944d49722023-12-01T23:03:00ZengMDPI AGMolecules1420-30492022-07-012715477810.3390/molecules27154778Zero-Biased Photoelectrochemical Detection of Cardiac Biomarker Myoglobin Based on CdSeS/ZnS Quantum Dots and Barium Titanate PerovskiteFernanda M. R. Lima0Alan S. de Menezes1Adeilton P. Maciel2Francisco S. M. Sinfrônio3Lauro T. Kubota4Flávio S. Damos5Rita C. S. Luz6Department of Chemistry, Federal University of Maranhão, São Luís 65080-805, BrazilDepartment of Physics, Federal University of Maranhão, São Luís 65080-805, BrazilDepartment of Chemistry, Federal University of Maranhão, São Luís 65080-805, BrazilDepartment of Electrical Engineering, Federal University of Maranhão, São Luís 65080-805, BrazilInstitute of Chemistry, State University of Campinas, Campinas 13083-970, BrazilDepartment of Chemistry, Federal University of Maranhão, São Luís 65080-805, BrazilDepartment of Chemistry, Federal University of Maranhão, São Luís 65080-805, BrazilCardiovascular diseases are considered one of the leading causes of premature mortality of patients worldwide. Therefore, rapid diagnosis of these diseases is crucial to ensure the patient’s survival. During a heart attack or severe muscle damage, myoglobin is rapidly released in the body to constitute itself as a precise biomarker of acute myocardial infarction. Thus, we described the photoelectrochemical immunosensor development to detect myoglobin. It was based on fluorine-doped tin oxide modified with CdSeS/ZnSe quantum dots and barium titanate (BTO), designated as CdSeS/ZnSQDS/BTO. It was characterized by scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDX), transmission electron microscopy (TEM), X-ray diffraction (XRD), electrochemical impedance spectroscopy (EIS), and amperometry. The anodic photocurrent at the potential of 0 V (vs. Ag/AgCl) and pH 7.4 was found linearly related to the myoglobin (Mb) concentration from 0.01 to 1000 ng mL<sup>−1</sup>. Furthermore, the immunosensor showed an average recovery rate of 95.7–110.7% for the determination of myoglobin.https://www.mdpi.com/1420-3049/27/15/4778immunosensorphotoelectrochemistrymyoglobinbarium titanateCdSeS/ZnS quantum dots |
| spellingShingle | Fernanda M. R. Lima Alan S. de Menezes Adeilton P. Maciel Francisco S. M. Sinfrônio Lauro T. Kubota Flávio S. Damos Rita C. S. Luz Zero-Biased Photoelectrochemical Detection of Cardiac Biomarker Myoglobin Based on CdSeS/ZnS Quantum Dots and Barium Titanate Perovskite Molecules immunosensor photoelectrochemistry myoglobin barium titanate CdSeS/ZnS quantum dots |
| title | Zero-Biased Photoelectrochemical Detection of Cardiac Biomarker Myoglobin Based on CdSeS/ZnS Quantum Dots and Barium Titanate Perovskite |
| title_full | Zero-Biased Photoelectrochemical Detection of Cardiac Biomarker Myoglobin Based on CdSeS/ZnS Quantum Dots and Barium Titanate Perovskite |
| title_fullStr | Zero-Biased Photoelectrochemical Detection of Cardiac Biomarker Myoglobin Based on CdSeS/ZnS Quantum Dots and Barium Titanate Perovskite |
| title_full_unstemmed | Zero-Biased Photoelectrochemical Detection of Cardiac Biomarker Myoglobin Based on CdSeS/ZnS Quantum Dots and Barium Titanate Perovskite |
| title_short | Zero-Biased Photoelectrochemical Detection of Cardiac Biomarker Myoglobin Based on CdSeS/ZnS Quantum Dots and Barium Titanate Perovskite |
| title_sort | zero biased photoelectrochemical detection of cardiac biomarker myoglobin based on cdses zns quantum dots and barium titanate perovskite |
| topic | immunosensor photoelectrochemistry myoglobin barium titanate CdSeS/ZnS quantum dots |
| url | https://www.mdpi.com/1420-3049/27/15/4778 |
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