Multifaceted Factors Causing Conflicting Outcomes in Herb-Drug Interactions
Metabolic enzyme and/or transporter-mediated pharmacokinetic (PK) changes in a drug caused by concomitant herbal products have been a primary issue of herb and drug interactions (HDIs), because PK changes of a drug may result in the alternation of efficacy and toxicity. Studies on HDIs have been car...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/1/43 |
| _version_ | 1797543079700332544 |
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| author | Young Hee Choi Young-Won Chin |
| author_facet | Young Hee Choi Young-Won Chin |
| author_sort | Young Hee Choi |
| collection | DOAJ |
| description | Metabolic enzyme and/or transporter-mediated pharmacokinetic (PK) changes in a drug caused by concomitant herbal products have been a primary issue of herb and drug interactions (HDIs), because PK changes of a drug may result in the alternation of efficacy and toxicity. Studies on HDIs have been carried out by predictive in vitro and in vivo preclinical studies, and clinical trials. Nevertheless, the discrepancies between predictive data and the clinical significance on HDIs still exist, and different reports of HDIs add to rather than clarify the confusion regarding the use of herbal products and drug combinations. Here, we briefly review the underlying mechanisms causing PK-based HDIs, and more importantly summarize challenging issues, such as dose and treatment period effects, to be considered in study designs and interpretations of HDI evaluations. |
| first_indexed | 2024-03-10T13:39:36Z |
| format | Article |
| id | doaj.art-58143aa73351498a93a79900ce072d27 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T13:39:36Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-58143aa73351498a93a79900ce072d272023-11-21T03:07:52ZengMDPI AGPharmaceutics1999-49232020-12-011314310.3390/pharmaceutics13010043Multifaceted Factors Causing Conflicting Outcomes in Herb-Drug InteractionsYoung Hee Choi0Young-Won Chin1College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University_Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang-si, Gyeonggi-do 10326, KoreaCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, KoreaMetabolic enzyme and/or transporter-mediated pharmacokinetic (PK) changes in a drug caused by concomitant herbal products have been a primary issue of herb and drug interactions (HDIs), because PK changes of a drug may result in the alternation of efficacy and toxicity. Studies on HDIs have been carried out by predictive in vitro and in vivo preclinical studies, and clinical trials. Nevertheless, the discrepancies between predictive data and the clinical significance on HDIs still exist, and different reports of HDIs add to rather than clarify the confusion regarding the use of herbal products and drug combinations. Here, we briefly review the underlying mechanisms causing PK-based HDIs, and more importantly summarize challenging issues, such as dose and treatment period effects, to be considered in study designs and interpretations of HDI evaluations.https://www.mdpi.com/1999-4923/13/1/43herb-drug interactionpharmacokineticsdosetreatment period |
| spellingShingle | Young Hee Choi Young-Won Chin Multifaceted Factors Causing Conflicting Outcomes in Herb-Drug Interactions Pharmaceutics herb-drug interaction pharmacokinetics dose treatment period |
| title | Multifaceted Factors Causing Conflicting Outcomes in Herb-Drug Interactions |
| title_full | Multifaceted Factors Causing Conflicting Outcomes in Herb-Drug Interactions |
| title_fullStr | Multifaceted Factors Causing Conflicting Outcomes in Herb-Drug Interactions |
| title_full_unstemmed | Multifaceted Factors Causing Conflicting Outcomes in Herb-Drug Interactions |
| title_short | Multifaceted Factors Causing Conflicting Outcomes in Herb-Drug Interactions |
| title_sort | multifaceted factors causing conflicting outcomes in herb drug interactions |
| topic | herb-drug interaction pharmacokinetics dose treatment period |
| url | https://www.mdpi.com/1999-4923/13/1/43 |
| work_keys_str_mv | AT youngheechoi multifacetedfactorscausingconflictingoutcomesinherbdruginteractions AT youngwonchin multifacetedfactorscausingconflictingoutcomesinherbdruginteractions |