The Effect of Eight Weeks of Continuous Endurance Training on ICAM-1 and VCAM-1 Expression in the Heart Tissue of Rats
BACKGROUND AND OBJECTIVE: The expression of adhesion molecules in the heart tissue is considered as an important indicator in the estimation of coronary artery disease risk. Since physical activity is effective in reducing symptoms of cardiac disease, the purpose of the present study was to investig...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Babol University of Medical Sciences
2019-12-01
|
| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| Subjects: | |
| Online Access: | http://jbums.org/article-1-8229-en.html |
| _version_ | 1818404284562145280 |
|---|---|
| author | MR Asad M Sistani A Barzegari |
| author_facet | MR Asad M Sistani A Barzegari |
| author_sort | MR Asad |
| collection | DOAJ |
| description | BACKGROUND AND OBJECTIVE: The expression of adhesion molecules in the heart tissue is considered as an important indicator in the estimation of coronary artery disease risk. Since physical activity is effective in reducing symptoms of cardiac disease, the purpose of the present study was to investigate the effect of eight weeks of continuous endurance training on ICAM-1 and VCAM-1 expression in the heart tissue of rats.
METHODS: In this experimental study, 12 eight weeks male Wistar rats with an average weight of 263±12 g were randomly divided into 2 groups: control (n=6) and exercise (n=6) were divided. The training program included 8 weeks of running on a treadmill with a 70 to 75% VO2max intensity (five days a week and 30 minutes each day). The expression of ICAM-1 and VCAM-1 genes were measured by Real-time PCR and compared in two groups.
FINDINGS: The results showed that 8 weeks of continuous endurance training reduced the expression of ICAM-1 in the heart tissue. In comparison, there was a significant difference between the control group (0.29±0.05) and training (0.10±0.03) (p=0.017). In addition, it was shown that the expression of VCAM-1 in the heart tissue significantly increased in training group (0.85±0.04) compared to the control group (0.22±0.03) (p=0.001).
CONCLUSION: The results of this study showed that continuous endurance training altered the expression of adhesion molecules in heart tissue associated with systemic inflammation, which could be a suitable solution for reducing fat deposits in the heart tissue and preventing its harm. |
| first_indexed | 2024-12-14T08:37:43Z |
| format | Article |
| id | doaj.art-581590026c33462db2ba5806256d8050 |
| institution | Directory Open Access Journal |
| issn | 1561-4107 2251-7170 |
| language | English |
| last_indexed | 2024-12-14T08:37:43Z |
| publishDate | 2019-12-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| spelling | doaj.art-581590026c33462db2ba5806256d80502022-12-21T23:09:22ZengBabol University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul1561-41072251-71702019-12-01211230236The Effect of Eight Weeks of Continuous Endurance Training on ICAM-1 and VCAM-1 Expression in the Heart Tissue of RatsMR Asad0M Sistani1A Barzegari2 1. Department of Physical Education and Sport, Payame Noor University, Tehran, I.R.Iran 1. Department of Physical Education and Sport, Payame Noor University, Tehran, I.R.Iran 1. Department of Physical Education and Sport, Payame Noor University, Tehran, I.R.Iran BACKGROUND AND OBJECTIVE: The expression of adhesion molecules in the heart tissue is considered as an important indicator in the estimation of coronary artery disease risk. Since physical activity is effective in reducing symptoms of cardiac disease, the purpose of the present study was to investigate the effect of eight weeks of continuous endurance training on ICAM-1 and VCAM-1 expression in the heart tissue of rats. METHODS: In this experimental study, 12 eight weeks male Wistar rats with an average weight of 263±12 g were randomly divided into 2 groups: control (n=6) and exercise (n=6) were divided. The training program included 8 weeks of running on a treadmill with a 70 to 75% VO2max intensity (five days a week and 30 minutes each day). The expression of ICAM-1 and VCAM-1 genes were measured by Real-time PCR and compared in two groups. FINDINGS: The results showed that 8 weeks of continuous endurance training reduced the expression of ICAM-1 in the heart tissue. In comparison, there was a significant difference between the control group (0.29±0.05) and training (0.10±0.03) (p=0.017). In addition, it was shown that the expression of VCAM-1 in the heart tissue significantly increased in training group (0.85±0.04) compared to the control group (0.22±0.03) (p=0.001). CONCLUSION: The results of this study showed that continuous endurance training altered the expression of adhesion molecules in heart tissue associated with systemic inflammation, which could be a suitable solution for reducing fat deposits in the heart tissue and preventing its harm.http://jbums.org/article-1-8229-en.htmlendurance trainingratsintercellular adhesion molecule-1vascular cell adhesion molecule-1. |
| spellingShingle | MR Asad M Sistani A Barzegari The Effect of Eight Weeks of Continuous Endurance Training on ICAM-1 and VCAM-1 Expression in the Heart Tissue of Rats Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul endurance training rats intercellular adhesion molecule-1 vascular cell adhesion molecule-1. |
| title | The Effect of Eight Weeks of Continuous Endurance Training on ICAM-1 and VCAM-1 Expression in the Heart Tissue of Rats |
| title_full | The Effect of Eight Weeks of Continuous Endurance Training on ICAM-1 and VCAM-1 Expression in the Heart Tissue of Rats |
| title_fullStr | The Effect of Eight Weeks of Continuous Endurance Training on ICAM-1 and VCAM-1 Expression in the Heart Tissue of Rats |
| title_full_unstemmed | The Effect of Eight Weeks of Continuous Endurance Training on ICAM-1 and VCAM-1 Expression in the Heart Tissue of Rats |
| title_short | The Effect of Eight Weeks of Continuous Endurance Training on ICAM-1 and VCAM-1 Expression in the Heart Tissue of Rats |
| title_sort | effect of eight weeks of continuous endurance training on icam 1 and vcam 1 expression in the heart tissue of rats |
| topic | endurance training rats intercellular adhesion molecule-1 vascular cell adhesion molecule-1. |
| url | http://jbums.org/article-1-8229-en.html |
| work_keys_str_mv | AT mrasad theeffectofeightweeksofcontinuousendurancetrainingonicam1andvcam1expressioninthehearttissueofrats AT msistani theeffectofeightweeksofcontinuousendurancetrainingonicam1andvcam1expressioninthehearttissueofrats AT abarzegari theeffectofeightweeksofcontinuousendurancetrainingonicam1andvcam1expressioninthehearttissueofrats AT mrasad effectofeightweeksofcontinuousendurancetrainingonicam1andvcam1expressioninthehearttissueofrats AT msistani effectofeightweeksofcontinuousendurancetrainingonicam1andvcam1expressioninthehearttissueofrats AT abarzegari effectofeightweeksofcontinuousendurancetrainingonicam1andvcam1expressioninthehearttissueofrats |