Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis

Cost-effective animal models that accurately reflect the pathological progression of pulmonary tuberculosis are needed to screen and evaluate novel tuberculosis drugs and drug regimens. Pulmonary disease in humans is characterized by a number of heterogeneous lesion types that reflect differences in...

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Bibliographic Details
Main Authors: Scott M. Irwin, Emily Driver, Edward Lyon, Christopher Schrupp, Gavin Ryan, Mercedes Gonzalez-Juarrero, Randall J. Basaraba, Eric L. Nuermberger, Anne J. Lenaerts
Format: Article
Language:English
Published: The Company of Biologists 2015-06-01
Series:Disease Models & Mechanisms
Subjects:
C3HeB/FeJ
Tuberculosis
Mouse models
Chemotherapy
Neutrophil
Online Access:http://dmm.biologists.org/content/8/6/591

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