The varicella-zoster virus ORF47 kinase interferes with host innate immune response by inhibiting the activation of IRF3.

The varicella-zoster virus ORF47 kinase interferes with host innate immune response by inhibiting the activation of IRF3.

The innate immune response constitutes the first line of host defence that limits viral spread and plays an important role in the activation of adaptive immune response. Viral components are recognized by specific host pathogen recognition receptors triggering the activation of IRF3. IRF3, along wit...

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Bibliographic Details
Main Authors: Patricia Vandevenne, Marielle Lebrun, Nadia El Mjiyad, Isabelle Ote, Emmanuel Di Valentin, Yvette Habraken, Estelle Dortu, Jacques Piette, Catherine Sadzot-Delvaux
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21347389/?tool=EBI

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