Diverse roles of mitochondria in ischemic stroke
Stroke is the leading cause of adult disability and mortality in most developing and developed countries. The current best practices for patients with acute ischemic stroke include intravenous tissue plasminogen activator and endovascular thrombectomy for large-vessel occlusion to improve clinical o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-06-01
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| Series: | Redox Biology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231718300570 |
| _version_ | 1819104451708846080 |
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| author | Jenq-Lin Yang Sujira Mukda Shang-Der Chen |
| author_facet | Jenq-Lin Yang Sujira Mukda Shang-Der Chen |
| author_sort | Jenq-Lin Yang |
| collection | DOAJ |
| description | Stroke is the leading cause of adult disability and mortality in most developing and developed countries. The current best practices for patients with acute ischemic stroke include intravenous tissue plasminogen activator and endovascular thrombectomy for large-vessel occlusion to improve clinical outcomes. However, only a limited portion of patients receive thrombolytic therapy or endovascular treatment because the therapeutic time window after ischemic stroke is narrow. To address the current shortage of stroke management approaches, it is critical to identify new potential therapeutic targets. The mitochondrion is an often overlooked target for the clinical treatment of stroke. Early studies of mitochondria focused on their bioenergetic role; however, these organelles are now known to be important in a wide range of cellular functions and signaling events. This review aims to summarize the current knowledge on the mitochondrial molecular mechanisms underlying cerebral ischemia and involved in reactive oxygen species generation and scavenging, electron transport chain dysfunction, apoptosis, mitochondrial dynamics and biogenesis, and inflammation. A better understanding of the roles of mitochondria in ischemia-related neuronal death and protection may provide a rationale for the development of innovative therapeutic regimens for ischemic stroke and other stroke syndromes. Keywords: Mitochondria, Ischemic stroke, Apoptosis, Mitochondrial biogenesis, Mitochondrial dynamics, Mitophagy, Inflammation |
| first_indexed | 2024-12-22T02:06:34Z |
| format | Article |
| id | doaj.art-5818bae3581d4df3a9088301ad329d32 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-12-22T02:06:34Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-5818bae3581d4df3a9088301ad329d322022-12-21T18:42:30ZengElsevierRedox Biology2213-23172018-06-0116263275Diverse roles of mitochondria in ischemic strokeJenq-Lin Yang0Sujira Mukda1Shang-Der Chen2Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, 123 Dapi Road, Kaohsiung 83301, Taiwan, ROCInstitute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, 123 Dapi Road, Kaohsiung 83301, Taiwan, ROC; Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, 25/25 Phuttamonthon 4 Road, Salaya, Nakhon Pathom 73170, ThailandInstitute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, 123 Dapi Road, Kaohsiung 83301, Taiwan, ROC; Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, 123 Dapi Road, Kaohsiung 83301, Taiwan, ROC; College of Medicine, Chang Gung University, 259 Wenhua 1st Road, Taoyuan 33302, Taiwan, ROC; Corresponding author at: Department of Neurology and Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, 123 Dapi Road, Kaohsiung 83301, Taiwan.Stroke is the leading cause of adult disability and mortality in most developing and developed countries. The current best practices for patients with acute ischemic stroke include intravenous tissue plasminogen activator and endovascular thrombectomy for large-vessel occlusion to improve clinical outcomes. However, only a limited portion of patients receive thrombolytic therapy or endovascular treatment because the therapeutic time window after ischemic stroke is narrow. To address the current shortage of stroke management approaches, it is critical to identify new potential therapeutic targets. The mitochondrion is an often overlooked target for the clinical treatment of stroke. Early studies of mitochondria focused on their bioenergetic role; however, these organelles are now known to be important in a wide range of cellular functions and signaling events. This review aims to summarize the current knowledge on the mitochondrial molecular mechanisms underlying cerebral ischemia and involved in reactive oxygen species generation and scavenging, electron transport chain dysfunction, apoptosis, mitochondrial dynamics and biogenesis, and inflammation. A better understanding of the roles of mitochondria in ischemia-related neuronal death and protection may provide a rationale for the development of innovative therapeutic regimens for ischemic stroke and other stroke syndromes. Keywords: Mitochondria, Ischemic stroke, Apoptosis, Mitochondrial biogenesis, Mitochondrial dynamics, Mitophagy, Inflammationhttp://www.sciencedirect.com/science/article/pii/S2213231718300570 |
| spellingShingle | Jenq-Lin Yang Sujira Mukda Shang-Der Chen Diverse roles of mitochondria in ischemic stroke Redox Biology |
| title | Diverse roles of mitochondria in ischemic stroke |
| title_full | Diverse roles of mitochondria in ischemic stroke |
| title_fullStr | Diverse roles of mitochondria in ischemic stroke |
| title_full_unstemmed | Diverse roles of mitochondria in ischemic stroke |
| title_short | Diverse roles of mitochondria in ischemic stroke |
| title_sort | diverse roles of mitochondria in ischemic stroke |
| url | http://www.sciencedirect.com/science/article/pii/S2213231718300570 |
| work_keys_str_mv | AT jenqlinyang diverserolesofmitochondriainischemicstroke AT sujiramukda diverserolesofmitochondriainischemicstroke AT shangderchen diverserolesofmitochondriainischemicstroke |