Transferrin receptor-1 and VEGF are prognostic factors for osteosarcoma
Abstract Background Osteosarcoma is aggressive and prognostic biomarkers are important to predict the outcomes of surgery and chemotherapy. Here, we investigated the potential of transferrin receptor-1 (TfR1) and vascular endothelial growth factor (VEGF) as prognostic markers of osteosarcoma. Method...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-09-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13018-019-1301-z |
| _version_ | 1797999194929102848 |
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| author | Hongzeng Wu Jinming Zhang Ruoheng Dai Jianfa Xu Helin Feng |
| author_facet | Hongzeng Wu Jinming Zhang Ruoheng Dai Jianfa Xu Helin Feng |
| author_sort | Hongzeng Wu |
| collection | DOAJ |
| description | Abstract Background Osteosarcoma is aggressive and prognostic biomarkers are important to predict the outcomes of surgery and chemotherapy. Here, we investigated the potential of transferrin receptor-1 (TfR1) and vascular endothelial growth factor (VEGF) as prognostic markers of osteosarcoma. Methods TfR1 and VEGF in osteosarcoma samples from a cohort of 53 osteosarcoma patients were detected by immunohistochemistry analysis. The correlation of TfR1 and VEGF levels with clinicopathological parameters was analyzed by Pearson chi-square and Spearman-rho tests. Overall patient survival was analyzed by the Kaplan-Meier method. Results We found that TfR1 and VEGF expression levels were low in 20.8% and 18.9%; modest in 35.8% and 35.8%; and high in 43.4% and 45.3% of osteosarcoma patients, respectively. TfR1 and VEGF expression was significantly correlated to histologic grade, Enneking stage, and distant metastasis. TfR1 expression was significantly correlated to VEGF expression and both TfR1 expression and VEGF expression were correlated to shorter overall survival. Conclusions TfR1 and VEGF are potential prognostic factors for osteosarcoma. |
| first_indexed | 2024-04-11T11:00:50Z |
| format | Article |
| id | doaj.art-5819d8d9d23f40859cc150a21942f6be |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T11:00:50Z |
| publishDate | 2019-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-5819d8d9d23f40859cc150a21942f6be2022-12-22T04:28:38ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2019-09-011411510.1186/s13018-019-1301-zTransferrin receptor-1 and VEGF are prognostic factors for osteosarcomaHongzeng Wu0Jinming Zhang1Ruoheng Dai2Jianfa Xu3Helin Feng4Department of Orthopedics, The Fourth Hospital of Hebei Medical UniversityDepartment of Orthopedics, The Fourth Hospital of Hebei Medical UniversityDepartment of Pediatrics, The Fourth Hospital of Hebei Medical UniversityDepartment of Orthopedics, The Fourth Hospital of Hebei Medical UniversityDepartment of Orthopedics, The Fourth Hospital of Hebei Medical UniversityAbstract Background Osteosarcoma is aggressive and prognostic biomarkers are important to predict the outcomes of surgery and chemotherapy. Here, we investigated the potential of transferrin receptor-1 (TfR1) and vascular endothelial growth factor (VEGF) as prognostic markers of osteosarcoma. Methods TfR1 and VEGF in osteosarcoma samples from a cohort of 53 osteosarcoma patients were detected by immunohistochemistry analysis. The correlation of TfR1 and VEGF levels with clinicopathological parameters was analyzed by Pearson chi-square and Spearman-rho tests. Overall patient survival was analyzed by the Kaplan-Meier method. Results We found that TfR1 and VEGF expression levels were low in 20.8% and 18.9%; modest in 35.8% and 35.8%; and high in 43.4% and 45.3% of osteosarcoma patients, respectively. TfR1 and VEGF expression was significantly correlated to histologic grade, Enneking stage, and distant metastasis. TfR1 expression was significantly correlated to VEGF expression and both TfR1 expression and VEGF expression were correlated to shorter overall survival. Conclusions TfR1 and VEGF are potential prognostic factors for osteosarcoma.http://link.springer.com/article/10.1186/s13018-019-1301-zTransferrin receptor-1VEGFPrognosisOsteosarcoma |
| spellingShingle | Hongzeng Wu Jinming Zhang Ruoheng Dai Jianfa Xu Helin Feng Transferrin receptor-1 and VEGF are prognostic factors for osteosarcoma Journal of Orthopaedic Surgery and Research Transferrin receptor-1 VEGF Prognosis Osteosarcoma |
| title | Transferrin receptor-1 and VEGF are prognostic factors for osteosarcoma |
| title_full | Transferrin receptor-1 and VEGF are prognostic factors for osteosarcoma |
| title_fullStr | Transferrin receptor-1 and VEGF are prognostic factors for osteosarcoma |
| title_full_unstemmed | Transferrin receptor-1 and VEGF are prognostic factors for osteosarcoma |
| title_short | Transferrin receptor-1 and VEGF are prognostic factors for osteosarcoma |
| title_sort | transferrin receptor 1 and vegf are prognostic factors for osteosarcoma |
| topic | Transferrin receptor-1 VEGF Prognosis Osteosarcoma |
| url | http://link.springer.com/article/10.1186/s13018-019-1301-z |
| work_keys_str_mv | AT hongzengwu transferrinreceptor1andvegfareprognosticfactorsforosteosarcoma AT jinmingzhang transferrinreceptor1andvegfareprognosticfactorsforosteosarcoma AT ruohengdai transferrinreceptor1andvegfareprognosticfactorsforosteosarcoma AT jianfaxu transferrinreceptor1andvegfareprognosticfactorsforosteosarcoma AT helinfeng transferrinreceptor1andvegfareprognosticfactorsforosteosarcoma |