Hybrid Cyclobutane/Proline-Containing Peptidomimetics: The Conformational Constraint Influences Their Cell-Penetration Ability

Hybrid Cyclobutane/Proline-Containing Peptidomimetics: The Conformational Constraint Influences Their Cell-Penetration Ability

A new family of hybrid β,γ-peptidomimetics consisting of a repetitive unit formed by a chiral cyclobutane-containing <i>trans</i>-β-amino acid plus a <i>N</i><sup>α</sup>-functionalized <i>trans</i>-γ-amino-<span style="font-variant: small-caps...

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Bibliographic Details
Main Authors: Ona Illa, Jimena Ospina, José-Emilio Sánchez-Aparicio, Ximena Pulido, María Ángeles Abengozar, Nerea Gaztelumendi, Daniel Carbajo, Carme Nogués, Luis Rivas, Jean-Didier Maréchal, Miriam Royo, Rosa M. Ortuño
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
peptidomimetics
cell penetrating peptides
conformational bias
rigidity
charge-preorganization
Online Access:https://www.mdpi.com/1422-0067/22/10/5092

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