Nanomedicine-based co-delivery of a calcium channel inhibitor and a small molecule targeting CD47 for lung cancer immunotherapy
Abstract Pro-tumoral macrophages in lung tumors present a significant challenge in immunotherapy. Here, we introduce a pH-responsive nanomedicine approach for activating anti-tumoral macrophages and dendritic cells. Using a layered double hydroxide nanosheet carrier, we co-deliver a T-type calcium c...
Main Authors: | Yuedong Guo, Qunqun Bao, Ping Hu, Jianlin Shi |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-11-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-42972-2 |
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