Bivalent Vaccine against <i>Streptococcus agalactiae</i> and <i>Aeromonas hydrophila</i> in Nile Tilapia (<i>Oreochromis niloticus</i>): A Laboratory-Phase and Large-Scale Study
One of the main factors limiting tilapia’s production is the occurrence of infections caused by <i>Aeromonas</i> and <i>Streptococcus</i> species. This work intended to evaluate a bivalent vaccine against <i>A. hydrophila</i> and <i>S. agalactiae</i> b...
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| Format: | Article |
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MDPI AG
2023-10-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/21/3338 |
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| author | Açucena Veleh Rivas Angelo Gabriel Vidal dos Santos Adrieli Barboza de Souza Gilson Bueno Junior Gabriela Fernandes de Souza Estevam Martins de Souza Louisiane de Carvalho Nunes Kelvinson Fernandes Viana |
| author_facet | Açucena Veleh Rivas Angelo Gabriel Vidal dos Santos Adrieli Barboza de Souza Gilson Bueno Junior Gabriela Fernandes de Souza Estevam Martins de Souza Louisiane de Carvalho Nunes Kelvinson Fernandes Viana |
| author_sort | Açucena Veleh Rivas |
| collection | DOAJ |
| description | One of the main factors limiting tilapia’s production is the occurrence of infections caused by <i>Aeromonas</i> and <i>Streptococcus</i> species. This work intended to evaluate a bivalent vaccine against <i>A. hydrophila</i> and <i>S. agalactiae</i> by intraperitoneal (i.p) administration in Nile tilapia (<i>Oreochromis niloticus</i>) in Brazil. The study was carried out in two phases: one in the laboratory, on a small scale, and from the results obtained, the study was expanded to a large scale in a production system in cages. The vaccine proved to be safe and effective in laboratory tests, with a vaccine efficacy (VE) of 93.66%. However, in large-scale tests with 12,000 tilapias, the VE was 59.14%, with a better food conversion ratio (1.54 kg) in the vaccinated group compared to the control group (1.27 kg). These results corroborate the efficiency of this tested vaccine; however, they indicate the need for field tests to attest to real protection. |
| first_indexed | 2024-03-11T11:34:36Z |
| format | Article |
| id | doaj.art-581a9a8c90ce4126bf6e113169f83900 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-11T11:34:36Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-581a9a8c90ce4126bf6e113169f839002023-11-10T14:57:46ZengMDPI AGAnimals2076-26152023-10-011321333810.3390/ani13213338Bivalent Vaccine against <i>Streptococcus agalactiae</i> and <i>Aeromonas hydrophila</i> in Nile Tilapia (<i>Oreochromis niloticus</i>): A Laboratory-Phase and Large-Scale StudyAçucena Veleh Rivas0Angelo Gabriel Vidal dos Santos1Adrieli Barboza de Souza2Gilson Bueno Junior3Gabriela Fernandes de Souza4Estevam Martins de Souza5Louisiane de Carvalho Nunes6Kelvinson Fernandes Viana7Vaccine Development Technology Laboratory, Latin American Institute of Life and Nature Sciences, Federal University of Latin American Integration, Foz do Iguaçu 85870-650, BrazilVaccine Development Technology Laboratory, Latin American Institute of Life and Nature Sciences, Federal University of Latin American Integration, Foz do Iguaçu 85870-650, BrazilVaccine Development Technology Laboratory, Latin American Institute of Life and Nature Sciences, Federal University of Latin American Integration, Foz do Iguaçu 85870-650, BrazilVaccine Development Technology Laboratory, Latin American Institute of Life and Nature Sciences, Federal University of Latin American Integration, Foz do Iguaçu 85870-650, BrazilAlquimia Pescados, Foz do Iguaçu 85870-180, BrazilAlquimia Pescados, Foz do Iguaçu 85870-180, BrazilDepartment of Veterinary Medicine, Agricultural Sciences and Engineer Center, Federal University of Espírito Santo, Alegre 29500-000, BrazilVaccine Development Technology Laboratory, Latin American Institute of Life and Nature Sciences, Federal University of Latin American Integration, Foz do Iguaçu 85870-650, BrazilOne of the main factors limiting tilapia’s production is the occurrence of infections caused by <i>Aeromonas</i> and <i>Streptococcus</i> species. This work intended to evaluate a bivalent vaccine against <i>A. hydrophila</i> and <i>S. agalactiae</i> by intraperitoneal (i.p) administration in Nile tilapia (<i>Oreochromis niloticus</i>) in Brazil. The study was carried out in two phases: one in the laboratory, on a small scale, and from the results obtained, the study was expanded to a large scale in a production system in cages. The vaccine proved to be safe and effective in laboratory tests, with a vaccine efficacy (VE) of 93.66%. However, in large-scale tests with 12,000 tilapias, the VE was 59.14%, with a better food conversion ratio (1.54 kg) in the vaccinated group compared to the control group (1.27 kg). These results corroborate the efficiency of this tested vaccine; however, they indicate the need for field tests to attest to real protection.https://www.mdpi.com/2076-2615/13/21/3338immunizationfishaquaculturetilapiculturevaccine |
| spellingShingle | Açucena Veleh Rivas Angelo Gabriel Vidal dos Santos Adrieli Barboza de Souza Gilson Bueno Junior Gabriela Fernandes de Souza Estevam Martins de Souza Louisiane de Carvalho Nunes Kelvinson Fernandes Viana Bivalent Vaccine against <i>Streptococcus agalactiae</i> and <i>Aeromonas hydrophila</i> in Nile Tilapia (<i>Oreochromis niloticus</i>): A Laboratory-Phase and Large-Scale Study Animals immunization fish aquaculture tilapiculture vaccine |
| title | Bivalent Vaccine against <i>Streptococcus agalactiae</i> and <i>Aeromonas hydrophila</i> in Nile Tilapia (<i>Oreochromis niloticus</i>): A Laboratory-Phase and Large-Scale Study |
| title_full | Bivalent Vaccine against <i>Streptococcus agalactiae</i> and <i>Aeromonas hydrophila</i> in Nile Tilapia (<i>Oreochromis niloticus</i>): A Laboratory-Phase and Large-Scale Study |
| title_fullStr | Bivalent Vaccine against <i>Streptococcus agalactiae</i> and <i>Aeromonas hydrophila</i> in Nile Tilapia (<i>Oreochromis niloticus</i>): A Laboratory-Phase and Large-Scale Study |
| title_full_unstemmed | Bivalent Vaccine against <i>Streptococcus agalactiae</i> and <i>Aeromonas hydrophila</i> in Nile Tilapia (<i>Oreochromis niloticus</i>): A Laboratory-Phase and Large-Scale Study |
| title_short | Bivalent Vaccine against <i>Streptococcus agalactiae</i> and <i>Aeromonas hydrophila</i> in Nile Tilapia (<i>Oreochromis niloticus</i>): A Laboratory-Phase and Large-Scale Study |
| title_sort | bivalent vaccine against i streptococcus agalactiae i and i aeromonas hydrophila i in nile tilapia i oreochromis niloticus i a laboratory phase and large scale study |
| topic | immunization fish aquaculture tilapiculture vaccine |
| url | https://www.mdpi.com/2076-2615/13/21/3338 |
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