Enhanced Antitumoral Activity and Photoacoustic Imaging Properties of AuNP‐Enriched Endothelial Colony Forming Cells on Melanoma
Abstract Near infrared (NIR)‐resonant gold nanoparticles (AuNPs) hold great promise in cancer diagnostics and treatment. However, translating the theranostic potential of AuNPs into clinical applications still remains a challenge due to the difficulty to improve the efficiency and specificity of tum...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-02-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202001175 |
| _version_ | 1818415176252129280 |
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| author | Paolo Armanetti Anastasia Chillà Francesca Margheri Alessio Biagioni Luca Menichetti Giancarlo Margheri Fulvio Ratto Sonia Centi Francesca Bianchini Mirko Severi Rita Traversi Daniele Bani Matteo Lulli Tommaso Del Rosso Alessandra Mocali Elisabetta Rovida Mario Del Rosso Gabriella Fibbi Anna Laurenzana |
| author_facet | Paolo Armanetti Anastasia Chillà Francesca Margheri Alessio Biagioni Luca Menichetti Giancarlo Margheri Fulvio Ratto Sonia Centi Francesca Bianchini Mirko Severi Rita Traversi Daniele Bani Matteo Lulli Tommaso Del Rosso Alessandra Mocali Elisabetta Rovida Mario Del Rosso Gabriella Fibbi Anna Laurenzana |
| author_sort | Paolo Armanetti |
| collection | DOAJ |
| description | Abstract Near infrared (NIR)‐resonant gold nanoparticles (AuNPs) hold great promise in cancer diagnostics and treatment. However, translating the theranostic potential of AuNPs into clinical applications still remains a challenge due to the difficulty to improve the efficiency and specificity of tumor delivery in vivo as well as the clearance from liver and spleen to avoid off target toxicity. In this study, endothelial colony forming cells (ECFCs) are exploited as vehicles to deliver AuNPs to tumors. It is first demonstrated that ECFCs display a great capability to intake AuNPs without losing viability, and exert antitumor activity per se. Using a human melanoma xenograft mouse model, it is next demonstrated that AuNP‐loaded ECFCs retain their capacity to migrate to tumor sites in vivo 1 day after injection and stay in the tumor mass for more than 1 week. In addition, it is demonstrated that ECFC‐loaded AuNPs are efficiently cleared by the liver over time and do not elicit any sign of damage to healthy tissue. |
| first_indexed | 2024-12-14T11:30:50Z |
| format | Article |
| id | doaj.art-581ac02795924bf8bb2a46c5df6dc1cf |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-14T11:30:50Z |
| publishDate | 2021-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-581ac02795924bf8bb2a46c5df6dc1cf2022-12-21T23:03:17ZengWileyAdvanced Science2198-38442021-02-0184n/an/a10.1002/advs.202001175Enhanced Antitumoral Activity and Photoacoustic Imaging Properties of AuNP‐Enriched Endothelial Colony Forming Cells on MelanomaPaolo Armanetti0Anastasia Chillà1Francesca Margheri2Alessio Biagioni3Luca Menichetti4Giancarlo Margheri5Fulvio Ratto6Sonia Centi7Francesca Bianchini8Mirko Severi9Rita Traversi10Daniele Bani11Matteo Lulli12Tommaso Del Rosso13Alessandra Mocali14Elisabetta Rovida15Mario Del Rosso16Gabriella Fibbi17Anna Laurenzana18Institute of Clinical Physiology (IFC) National Research Council Pisa 56124 ItalyDepartment of Experimental and Clinical Biomedical Sciences University of Florence Florence 50134 ItalyDepartment of Experimental and Clinical Biomedical Sciences University of Florence Florence 50134 ItalyDepartment of Experimental and Clinical Biomedical Sciences University of Florence Florence 50134 ItalyInstitute of Clinical Physiology (IFC) National Research Council Pisa 56124 ItalyInstitute for Complex Systems National Research Council Sesto Fiorentino 50019 ItalyInstitute of Applied Physics “N. Carrara” National Research Council Sesto Fiorentino 50019 ItalyInstitute of Applied Physics “N. Carrara” National Research Council Sesto Fiorentino 50019 ItalyDepartment of Experimental and Clinical Biomedical Sciences University of Florence Florence 50134 ItalyDepartment of Chemistry “Ugo Schiff” University of Florence Sesto Fiorentino 50019 ItalyDepartment of Chemistry “Ugo Schiff” University of Florence Sesto Fiorentino 50019 ItalyDepartment of Clinical and Experimental Medicine University of Florence Florence 50134 ItalyDepartment of Experimental and Clinical Biomedical Sciences University of Florence Florence 50134 ItalyDepartment of Physics Pontifícia Universidade Católica do Rio de Janeiro Rio de Janeiro 22451‐900 BrazilDepartment of Experimental and Clinical Biomedical Sciences University of Florence Florence 50134 ItalyDepartment of Experimental and Clinical Biomedical Sciences University of Florence Florence 50134 ItalyDepartment of Experimental and Clinical Biomedical Sciences University of Florence Florence 50134 ItalyDepartment of Experimental and Clinical Biomedical Sciences University of Florence Florence 50134 ItalyDepartment of Experimental and Clinical Biomedical Sciences University of Florence Florence 50134 ItalyAbstract Near infrared (NIR)‐resonant gold nanoparticles (AuNPs) hold great promise in cancer diagnostics and treatment. However, translating the theranostic potential of AuNPs into clinical applications still remains a challenge due to the difficulty to improve the efficiency and specificity of tumor delivery in vivo as well as the clearance from liver and spleen to avoid off target toxicity. In this study, endothelial colony forming cells (ECFCs) are exploited as vehicles to deliver AuNPs to tumors. It is first demonstrated that ECFCs display a great capability to intake AuNPs without losing viability, and exert antitumor activity per se. Using a human melanoma xenograft mouse model, it is next demonstrated that AuNP‐loaded ECFCs retain their capacity to migrate to tumor sites in vivo 1 day after injection and stay in the tumor mass for more than 1 week. In addition, it is demonstrated that ECFC‐loaded AuNPs are efficiently cleared by the liver over time and do not elicit any sign of damage to healthy tissue.https://doi.org/10.1002/advs.202001175endothelial colony forming cellsgold nanoparticlesmelanomananomedicinephotoacoustic imaging |
| spellingShingle | Paolo Armanetti Anastasia Chillà Francesca Margheri Alessio Biagioni Luca Menichetti Giancarlo Margheri Fulvio Ratto Sonia Centi Francesca Bianchini Mirko Severi Rita Traversi Daniele Bani Matteo Lulli Tommaso Del Rosso Alessandra Mocali Elisabetta Rovida Mario Del Rosso Gabriella Fibbi Anna Laurenzana Enhanced Antitumoral Activity and Photoacoustic Imaging Properties of AuNP‐Enriched Endothelial Colony Forming Cells on Melanoma Advanced Science endothelial colony forming cells gold nanoparticles melanoma nanomedicine photoacoustic imaging |
| title | Enhanced Antitumoral Activity and Photoacoustic Imaging Properties of AuNP‐Enriched Endothelial Colony Forming Cells on Melanoma |
| title_full | Enhanced Antitumoral Activity and Photoacoustic Imaging Properties of AuNP‐Enriched Endothelial Colony Forming Cells on Melanoma |
| title_fullStr | Enhanced Antitumoral Activity and Photoacoustic Imaging Properties of AuNP‐Enriched Endothelial Colony Forming Cells on Melanoma |
| title_full_unstemmed | Enhanced Antitumoral Activity and Photoacoustic Imaging Properties of AuNP‐Enriched Endothelial Colony Forming Cells on Melanoma |
| title_short | Enhanced Antitumoral Activity and Photoacoustic Imaging Properties of AuNP‐Enriched Endothelial Colony Forming Cells on Melanoma |
| title_sort | enhanced antitumoral activity and photoacoustic imaging properties of aunp enriched endothelial colony forming cells on melanoma |
| topic | endothelial colony forming cells gold nanoparticles melanoma nanomedicine photoacoustic imaging |
| url | https://doi.org/10.1002/advs.202001175 |
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