Vaccination in Patients with Chronic Lymphocytic Leukemia: Current Problems
Relevance. Infections are the most common complication of chronic lymphocytic leukemia (CLL). According to registry studies, infections are the cause of death in 10–20% of patients. The emergence of new therapies for CLL has led to a decrease in mortality due to CLL progression, while mortality from...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2021-07-01
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| Series: | Эпидемиология и вакцинопрофилактика |
| Subjects: | |
| Online Access: | https://www.epidemvac.ru/jour/article/view/1294 |
| _version_ | 1797879512763990016 |
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| author | M. I. Kislova A. A. Petrenko M. P. Kostinov E. A. Nikitin |
| author_facet | M. I. Kislova A. A. Petrenko M. P. Kostinov E. A. Nikitin |
| author_sort | M. I. Kislova |
| collection | DOAJ |
| description | Relevance. Infections are the most common complication of chronic lymphocytic leukemia (CLL). According to registry studies, infections are the cause of death in 10–20% of patients. The emergence of new therapies for CLL has led to a decrease in mortality due to CLL progression, while mortality from infections has remained constant in recent decades.The aim of this literature review is to analyze the effectiveness of vaccine prophylaxis in patients with CLL as well as predictors of vaccine inefficiency according to published data, to explore current guidelines.Conclusions. The mechanisms of immune dysfunction in CLL are complex and associated with both the disease itself and the therapy. Numerous studies have shown that patients with CLL have an inadequate response to most vaccines given routinely in the general population. Vaccination in CLL patients remains a poorly developed topic. Additional clinical trials are needed to improve the effectiveness of vaccination in patients with CLL. |
| first_indexed | 2024-04-10T02:49:50Z |
| format | Article |
| id | doaj.art-581ae14b7528447db1958bdccd3e6ea8 |
| institution | Directory Open Access Journal |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| last_indexed | 2024-04-10T02:49:50Z |
| publishDate | 2021-07-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj.art-581ae14b7528447db1958bdccd3e6ea82023-03-13T07:43:18ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942021-07-012039110610.31631/2073-3046-2021-20-3-91-106755Vaccination in Patients with Chronic Lymphocytic Leukemia: Current ProblemsM. I. Kislova0A. A. Petrenko1M. P. Kostinov2E. A. Nikitin3ФГБУ «Национальный медицинский исследовательский центр гематологии» Министерства здравоохранения Российской Федерации; ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский Университет)ГБУЗ Городская клиническая больница имени С. П. Боткина Департамента здравоохранения города Москвы; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский Университет); ФГБНУ «НИИ вакцин и сывороток им. И. И. Мечникова»ГБУЗ Городская клиническая больница имени С. П. Боткина Департамента здравоохранения города Москвы; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииRelevance. Infections are the most common complication of chronic lymphocytic leukemia (CLL). According to registry studies, infections are the cause of death in 10–20% of patients. The emergence of new therapies for CLL has led to a decrease in mortality due to CLL progression, while mortality from infections has remained constant in recent decades.The aim of this literature review is to analyze the effectiveness of vaccine prophylaxis in patients with CLL as well as predictors of vaccine inefficiency according to published data, to explore current guidelines.Conclusions. The mechanisms of immune dysfunction in CLL are complex and associated with both the disease itself and the therapy. Numerous studies have shown that patients with CLL have an inadequate response to most vaccines given routinely in the general population. Vaccination in CLL patients remains a poorly developed topic. Additional clinical trials are needed to improve the effectiveness of vaccination in patients with CLL.https://www.epidemvac.ru/jour/article/view/1294хронический лимфолейкозвторичный иммунодефицитвакцинацияпневмококковая вакцинаантигриппозная вакцинанедостаточность специфических антител |
| spellingShingle | M. I. Kislova A. A. Petrenko M. P. Kostinov E. A. Nikitin Vaccination in Patients with Chronic Lymphocytic Leukemia: Current Problems Эпидемиология и вакцинопрофилактика хронический лимфолейкоз вторичный иммунодефицит вакцинация пневмококковая вакцина антигриппозная вакцина недостаточность специфических антител |
| title | Vaccination in Patients with Chronic Lymphocytic Leukemia: Current Problems |
| title_full | Vaccination in Patients with Chronic Lymphocytic Leukemia: Current Problems |
| title_fullStr | Vaccination in Patients with Chronic Lymphocytic Leukemia: Current Problems |
| title_full_unstemmed | Vaccination in Patients with Chronic Lymphocytic Leukemia: Current Problems |
| title_short | Vaccination in Patients with Chronic Lymphocytic Leukemia: Current Problems |
| title_sort | vaccination in patients with chronic lymphocytic leukemia current problems |
| topic | хронический лимфолейкоз вторичный иммунодефицит вакцинация пневмококковая вакцина антигриппозная вакцина недостаточность специфических антител |
| url | https://www.epidemvac.ru/jour/article/view/1294 |
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