A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles
Background and aimsOverweight or obesity is one of the most prevalent health burdens in companion pets and predisposes subjects to multiple comorbidities and reduced longevity. Dietary management and sufficient exercise are effective options for weight loss but challenged by modern lifestyle and cal...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1019615/full |
| _version_ | 1811235528288239616 |
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| author | Jinhua Xue Jinhua Xue Yuanyuan Lu Toujun Zou Wei Shi Shuang Wang Xu Cheng Juan Wan Yun Chen Min Wang Qingzheng Wang Qingzheng Wang Xia Yang Mingxing Ding Zhili Qi Yi Ding Manli Hu Xin Zhang Hongliang Li Hongliang Li Hongliang Li Yufeng Hu |
| author_facet | Jinhua Xue Jinhua Xue Yuanyuan Lu Toujun Zou Wei Shi Shuang Wang Xu Cheng Juan Wan Yun Chen Min Wang Qingzheng Wang Qingzheng Wang Xia Yang Mingxing Ding Zhili Qi Yi Ding Manli Hu Xin Zhang Hongliang Li Hongliang Li Hongliang Li Yufeng Hu |
| author_sort | Jinhua Xue |
| collection | DOAJ |
| description | Background and aimsOverweight or obesity is one of the most prevalent health burdens in companion pets and predisposes subjects to multiple comorbidities and reduced longevity. Dietary management and sufficient exercise are effective options for weight loss but challenged by modern lifestyle and calorie control-triggered malnutrition. Therefore, this study aimed to develop a formulated obesity control diet characterized by protein- and fiber-rich diet and supplemented with astaxanthin. We systemically evaluated global influences of the designed weight-loss diet on metabolic homeostasis in an obese beagle model.Materials and methodsBeagles were induced for obesity by a 24-week HFD treatment and then included into weight-loss programs. Briefly, obese beagles were randomly assigned to two groups that were fed with a formulated weight-loss diet or control diet, respectively. Body weight and body condition scoring (BCS) were analyzed biweekly. Computed tomography (CT), nuclear magnetic resonance imaging (MRI) measurements, and blood and adipose tissue biopsies were collected at 0 and 8 weeks. Plasma lipids and adipocyte size were also measured after 8 weeks of weight-loss diet feeding. The global influence of the formulated diet on the whole spectrum of gene panels were examined by adipose RNA assays.ResultsTwenty-four weeks of continuous HFD feeding significantly induced obesity in beagles, as evidenced by increased body weight, BCS, abdominal fat mass, and serum lipid levels. The obese and metabolic condition of the modeled canine were effectively improved by an 8-week weight-loss diet administration. Importantly, we did not observe any side effects during the weight loss duration. Transcriptional analysis of adipose tissues further supported that a weight-loss diet significantly increased energy metabolism-related pathways and decreased lipid synthesis-related pathways.ConclusionThe prescribed weight-loss diet exhibited profound benefits in canine weight management with well safety and palatability. These findings support effective strategies of nutritional management and supplementation approaches for weight control in companion animals. |
| first_indexed | 2024-04-12T11:53:39Z |
| format | Article |
| id | doaj.art-581f0d82bd1d4e58ad8552daac67f865 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-12T11:53:39Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-581f0d82bd1d4e58ad8552daac67f8652022-12-22T03:34:06ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-10-01910.3389/fnut.2022.10196151019615A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beaglesJinhua Xue0Jinhua Xue1Yuanyuan Lu2Toujun Zou3Wei Shi4Shuang Wang5Xu Cheng6Juan Wan7Yun Chen8Min Wang9Qingzheng Wang10Qingzheng Wang11Xia Yang12Mingxing Ding13Zhili Qi14Yi Ding15Manli Hu16Xin Zhang17Hongliang Li18Hongliang Li19Hongliang Li20Yufeng Hu21Gannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, ChinaDepartment of Physiology, School of Basic Medicine, Gannan Medical University, Ganzhou, ChinaGannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaSchool of Basic Medicine, Wuhan University, Wuhan, ChinaCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, ChinaGannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, ChinaGannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, ChinaDepartment of Cardiology, Huanggang Central Hospital, Huanggang, ChinaJiangxi Huichong Technology Co., Ltd., Ganzhou, ChinaGannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, ChinaDepartment of Physiology, School of Basic Medicine, Gannan Medical University, Ganzhou, ChinaGannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, ChinaCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, ChinaCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, ChinaCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, ChinaGannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, ChinaGannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, ChinaGannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaSchool of Basic Medicine, Wuhan University, Wuhan, ChinaGannan Innovation and Transformation Medical Research Institute, Key Laboratory of Cardiovascular Disease Prevention and Control, Ministry of Education, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, ChinaBackground and aimsOverweight or obesity is one of the most prevalent health burdens in companion pets and predisposes subjects to multiple comorbidities and reduced longevity. Dietary management and sufficient exercise are effective options for weight loss but challenged by modern lifestyle and calorie control-triggered malnutrition. Therefore, this study aimed to develop a formulated obesity control diet characterized by protein- and fiber-rich diet and supplemented with astaxanthin. We systemically evaluated global influences of the designed weight-loss diet on metabolic homeostasis in an obese beagle model.Materials and methodsBeagles were induced for obesity by a 24-week HFD treatment and then included into weight-loss programs. Briefly, obese beagles were randomly assigned to two groups that were fed with a formulated weight-loss diet or control diet, respectively. Body weight and body condition scoring (BCS) were analyzed biweekly. Computed tomography (CT), nuclear magnetic resonance imaging (MRI) measurements, and blood and adipose tissue biopsies were collected at 0 and 8 weeks. Plasma lipids and adipocyte size were also measured after 8 weeks of weight-loss diet feeding. The global influence of the formulated diet on the whole spectrum of gene panels were examined by adipose RNA assays.ResultsTwenty-four weeks of continuous HFD feeding significantly induced obesity in beagles, as evidenced by increased body weight, BCS, abdominal fat mass, and serum lipid levels. The obese and metabolic condition of the modeled canine were effectively improved by an 8-week weight-loss diet administration. Importantly, we did not observe any side effects during the weight loss duration. Transcriptional analysis of adipose tissues further supported that a weight-loss diet significantly increased energy metabolism-related pathways and decreased lipid synthesis-related pathways.ConclusionThe prescribed weight-loss diet exhibited profound benefits in canine weight management with well safety and palatability. These findings support effective strategies of nutritional management and supplementation approaches for weight control in companion animals.https://www.frontiersin.org/articles/10.3389/fnut.2022.1019615/fullobesitycaninedietweight losstranscriptional profile |
| spellingShingle | Jinhua Xue Jinhua Xue Yuanyuan Lu Toujun Zou Wei Shi Shuang Wang Xu Cheng Juan Wan Yun Chen Min Wang Qingzheng Wang Qingzheng Wang Xia Yang Mingxing Ding Zhili Qi Yi Ding Manli Hu Xin Zhang Hongliang Li Hongliang Li Hongliang Li Yufeng Hu A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles Frontiers in Nutrition obesity canine diet weight loss transcriptional profile |
| title | A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles |
| title_full | A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles |
| title_fullStr | A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles |
| title_full_unstemmed | A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles |
| title_short | A protein- and fiber-rich diet with astaxanthin alleviates high-fat diet-induced obesity in beagles |
| title_sort | protein and fiber rich diet with astaxanthin alleviates high fat diet induced obesity in beagles |
| topic | obesity canine diet weight loss transcriptional profile |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1019615/full |
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