Current methods of diagnosis and monitoring of a systemic amyloidosis course
Aim. To determine clinical significance of measuring blood levels of protein precursors of AA- and AL-amyloidosis - SAA and immunoglobulin free light chains (ILC), respectively. Material and methods. SAA concentrations were studied with ELISA in 43 rheumatoid arthritis (RA) patients including compli...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2011-08-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30902 |
| _version_ | 1828190413703348224 |
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| author | Vilen Vilevich Rameev Lidiya Vladimirovna Kozlovskaya Elena Aleksandrovna Malinina Anna Grigor'evna Serova Ivetta Nikolaevna Kogarko Bronislav Stanislavovich Kogarko Nina Vasil'evna Lyubimova V V Rameev L V Kozlovskaya E A Malinina A G Serova I N Kogarko B S Kogarko N V Lyubimova |
| author_facet | Vilen Vilevich Rameev Lidiya Vladimirovna Kozlovskaya Elena Aleksandrovna Malinina Anna Grigor'evna Serova Ivetta Nikolaevna Kogarko Bronislav Stanislavovich Kogarko Nina Vasil'evna Lyubimova V V Rameev L V Kozlovskaya E A Malinina A G Serova I N Kogarko B S Kogarko N V Lyubimova |
| author_sort | Vilen Vilevich Rameev |
| collection | DOAJ |
| description | Aim. To determine clinical significance of measuring blood levels of protein precursors of AA- and AL-amyloidosis - SAA and immunoglobulin free light chains (ILC), respectively.
Material and methods. SAA concentrations were studied with ELISA in 43 rheumatoid arthritis (RA) patients including complicated with reactive AA-amyloidosis (n = 31). Inflammation activity and its severity were studied (indices Li, richi, HAQ, DAS4). A modern quantitative nephelometric method Freelite estimated ILC levels in 31 patients with AL-amyloidosis.
Results. Patients with RA complicated with AA-amyloidosis and free of it had a strong correlation between blood serum SAA concentration and activity of joint disease. Elevated SAA concentrations to 160 mg/l (normal 10 mg/l) were detected in many patients with clinical remission of the joint syndrome. Significal inhibition of AA-amyloidosis progression was seen only in SAA concentration drop under 60 mg/l. For AL-amyloidosis patients ILC fall by less than 3 normal value means a 6-time increase in chances of a favourable outcome.
Conclusion. Monitoring of blood levels of proteins precursors of AA- and AL-amyloidosis is a key factor in prognosis of the disease and treatment efficacy. |
| first_indexed | 2024-04-12T08:22:03Z |
| format | Article |
| id | doaj.art-5821d029259d43a2bdbeadbe21c17514 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-04-12T08:22:03Z |
| publishDate | 2011-08-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-5821d029259d43a2bdbeadbe21c175142022-12-22T03:40:33Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422011-08-01838485427918Current methods of diagnosis and monitoring of a systemic amyloidosis courseVilen Vilevich RameevLidiya Vladimirovna KozlovskayaElena Aleksandrovna MalininaAnna Grigor'evna SerovaIvetta Nikolaevna KogarkoBronislav Stanislavovich KogarkoNina Vasil'evna LyubimovaV V Rameev0L V Kozlovskaya1E A Malinina2A G Serova3I N Kogarko4B S Kogarko5N V Lyubimova6I.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical UniversityN.N. Semenov Institute of Chemical Physics, MoscowN.N. Semenov Institute of Chemical Physics, MoscowN.N. Blokhin Russian Cancer Research Center, MoscowAim. To determine clinical significance of measuring blood levels of protein precursors of AA- and AL-amyloidosis - SAA and immunoglobulin free light chains (ILC), respectively. Material and methods. SAA concentrations were studied with ELISA in 43 rheumatoid arthritis (RA) patients including complicated with reactive AA-amyloidosis (n = 31). Inflammation activity and its severity were studied (indices Li, richi, HAQ, DAS4). A modern quantitative nephelometric method Freelite estimated ILC levels in 31 patients with AL-amyloidosis. Results. Patients with RA complicated with AA-amyloidosis and free of it had a strong correlation between blood serum SAA concentration and activity of joint disease. Elevated SAA concentrations to 160 mg/l (normal 10 mg/l) were detected in many patients with clinical remission of the joint syndrome. Significal inhibition of AA-amyloidosis progression was seen only in SAA concentration drop under 60 mg/l. For AL-amyloidosis patients ILC fall by less than 3 normal value means a 6-time increase in chances of a favourable outcome. Conclusion. Monitoring of blood levels of proteins precursors of AA- and AL-amyloidosis is a key factor in prognosis of the disease and treatment efficacy.https://ter-arkhiv.ru/0040-3660/article/view/30902saafreeliteaa-amyloidosisal-amyloidosisfree light chains of immunoglobulinssaafreelite |
| spellingShingle | Vilen Vilevich Rameev Lidiya Vladimirovna Kozlovskaya Elena Aleksandrovna Malinina Anna Grigor'evna Serova Ivetta Nikolaevna Kogarko Bronislav Stanislavovich Kogarko Nina Vasil'evna Lyubimova V V Rameev L V Kozlovskaya E A Malinina A G Serova I N Kogarko B S Kogarko N V Lyubimova Current methods of diagnosis and monitoring of a systemic amyloidosis course Терапевтический архив saa freelite aa-amyloidosis al-amyloidosis free light chains of immunoglobulins saa freelite |
| title | Current methods of diagnosis and monitoring of a systemic amyloidosis course |
| title_full | Current methods of diagnosis and monitoring of a systemic amyloidosis course |
| title_fullStr | Current methods of diagnosis and monitoring of a systemic amyloidosis course |
| title_full_unstemmed | Current methods of diagnosis and monitoring of a systemic amyloidosis course |
| title_short | Current methods of diagnosis and monitoring of a systemic amyloidosis course |
| title_sort | current methods of diagnosis and monitoring of a systemic amyloidosis course |
| topic | saa freelite aa-amyloidosis al-amyloidosis free light chains of immunoglobulins saa freelite |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30902 |
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