Δ 9-Tetrahydrocannabinol Toxicity and Validation of Cannabidiol on Brain Dopamine Levels: An Assessment on Cannabis Duplicity
Abstract Δ9-tetrahydrocannabinol (THC) of cannabis is the main psychoactive component which is a global significant concern to human health. Evaluation on THC reported its drastic effect on the brain dopaminergic (DAergic) system stimulating mesolimbic DA containing neurons thereby increasing the le...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-08-01
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| Series: | Natural Products and Bioprospecting |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s13659-020-00263-z |
| _version_ | 1818719901534126080 |
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| author | Swapnali Chetia Gaurab Borah |
| author_facet | Swapnali Chetia Gaurab Borah |
| author_sort | Swapnali Chetia |
| collection | DOAJ |
| description | Abstract Δ9-tetrahydrocannabinol (THC) of cannabis is the main psychoactive component which is a global significant concern to human health. Evaluation on THC reported its drastic effect on the brain dopaminergic (DAergic) system stimulating mesolimbic DA containing neurons thereby increasing the level of striatal DA. Cannabidiol (CBD), with its anxiolytic and anti-psychotic property, is potent to ameliorate the THC-induced DAergic variations. Legal authorization of cannabis use and its analogs in most countries led to a drastic dispute in the elicitation of cannabis products. With a recent increase in cannabis-induced disorder rates, the present review highlighted the detrimental effects of THC and the effects of CBD on THC induced alterations in DA synthesis and release. Alongside the reported data, uses of cannabis as a therapeutic medium in a number of health complications are also being briefly reviewed. These evaluated reports led to an anticipation of additional research contradictory to the findings of THC and CBD activity in the brain DAergic system and their medical implementations as therapeutics. Graphic Abstract |
| first_indexed | 2024-12-17T20:14:18Z |
| format | Article |
| id | doaj.art-582224fa38be4279b7575e7134fcb4b1 |
| institution | Directory Open Access Journal |
| issn | 2192-2195 2192-2209 |
| language | English |
| last_indexed | 2024-12-17T20:14:18Z |
| publishDate | 2020-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Natural Products and Bioprospecting |
| spelling | doaj.art-582224fa38be4279b7575e7134fcb4b12022-12-21T21:34:08ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092020-08-0110528529610.1007/s13659-020-00263-zΔ 9-Tetrahydrocannabinol Toxicity and Validation of Cannabidiol on Brain Dopamine Levels: An Assessment on Cannabis DuplicitySwapnali Chetia0Gaurab Borah1Department of Zoology, Rajiv Gandhi UniversityDepartment of Zoology, Rajiv Gandhi UniversityAbstract Δ9-tetrahydrocannabinol (THC) of cannabis is the main psychoactive component which is a global significant concern to human health. Evaluation on THC reported its drastic effect on the brain dopaminergic (DAergic) system stimulating mesolimbic DA containing neurons thereby increasing the level of striatal DA. Cannabidiol (CBD), with its anxiolytic and anti-psychotic property, is potent to ameliorate the THC-induced DAergic variations. Legal authorization of cannabis use and its analogs in most countries led to a drastic dispute in the elicitation of cannabis products. With a recent increase in cannabis-induced disorder rates, the present review highlighted the detrimental effects of THC and the effects of CBD on THC induced alterations in DA synthesis and release. Alongside the reported data, uses of cannabis as a therapeutic medium in a number of health complications are also being briefly reviewed. These evaluated reports led to an anticipation of additional research contradictory to the findings of THC and CBD activity in the brain DAergic system and their medical implementations as therapeutics. Graphic Abstracthttps://doi.org/10.1007/s13659-020-00263-zCannabisTetrahydrocannabinolCannabidiolDopamineMedicinal uses |
| spellingShingle | Swapnali Chetia Gaurab Borah Δ 9-Tetrahydrocannabinol Toxicity and Validation of Cannabidiol on Brain Dopamine Levels: An Assessment on Cannabis Duplicity Natural Products and Bioprospecting Cannabis Tetrahydrocannabinol Cannabidiol Dopamine Medicinal uses |
| title | Δ 9-Tetrahydrocannabinol Toxicity and Validation of Cannabidiol on Brain Dopamine Levels: An Assessment on Cannabis Duplicity |
| title_full | Δ 9-Tetrahydrocannabinol Toxicity and Validation of Cannabidiol on Brain Dopamine Levels: An Assessment on Cannabis Duplicity |
| title_fullStr | Δ 9-Tetrahydrocannabinol Toxicity and Validation of Cannabidiol on Brain Dopamine Levels: An Assessment on Cannabis Duplicity |
| title_full_unstemmed | Δ 9-Tetrahydrocannabinol Toxicity and Validation of Cannabidiol on Brain Dopamine Levels: An Assessment on Cannabis Duplicity |
| title_short | Δ 9-Tetrahydrocannabinol Toxicity and Validation of Cannabidiol on Brain Dopamine Levels: An Assessment on Cannabis Duplicity |
| title_sort | δ 9 tetrahydrocannabinol toxicity and validation of cannabidiol on brain dopamine levels an assessment on cannabis duplicity |
| topic | Cannabis Tetrahydrocannabinol Cannabidiol Dopamine Medicinal uses |
| url | https://doi.org/10.1007/s13659-020-00263-z |
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