<i>N</i><sup>4</sup>-(2-Amino-4-fluorophenyl)-<i>N</i><sup>1</sup>-(3-{2-[2-(3-{[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]amino}propoxy)ethoxy]ethoxy}propyl)terephthalamide

<i>N</i><sup>4</sup>-(2-Amino-4-fluorophenyl)-<i>N</i><sup>1</sup>-(3-{2-[2-(3-{[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]amino}propoxy)ethoxy]ethoxy}propyl)terephthalamide

The design of proteolysis targeting chimeras (PROTACs) has become a promising technology for modifying a protein of interest (POI) through protein degradation. Herein, we describe the synthetic pathway to develop <i>N</i><sup>4</sup>-(2-amino-4-fluorophenyl)-<i>N</i&...

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Bibliographic Details
Main Authors: Mohamed Abdelsalam, Matthes Zessin, Matthias Schmidt, Mike Schutkowski, Wolfgang Sippl
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molbank
Subjects:
PROTACs
HDAC isoforms
HDAC inhibitors
2-aminobenzamides
Online Access:https://www.mdpi.com/1422-8599/2022/4/M1501

Internet

https://www.mdpi.com/1422-8599/2022/4/M1501

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