Therapy of acute respiratory viral infections in adults in outpatient clinical practice: new opportunities for the prevention of bacterial complications (Results of the observational program RAPORT)
The frequency of routine prescription of systemic antibacterial drugs in outpatient practice is still unreasonably high despite the desire to reduce them. Under the auspices of the Alliance of Clinical Chemotherapists and Microbiologists, the observational program RAPORT was conducted to assess the...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ZAO "Consilium Medicum"
2023-06-01
|
| Series: | Consilium Medicum |
| Subjects: | |
| Online Access: | https://consilium.orscience.ru/2075-1753/article/viewFile/473521/125470 |
| _version_ | 1797798135032971264 |
|---|---|
| author | Sergey V. Yakovlev Leonid I. Dvoretskiy Vladimir A. Petrov |
| author_facet | Sergey V. Yakovlev Leonid I. Dvoretskiy Vladimir A. Petrov |
| author_sort | Sergey V. Yakovlev |
| collection | DOAJ |
| description | The frequency of routine prescription of systemic antibacterial drugs in outpatient practice is still unreasonably high despite the desire to reduce them. Under the auspices of the Alliance of Clinical Chemotherapists and Microbiologists, the observational program RAPORT was conducted to assess the therapeutic potential (including bacterial complications preventing) of Raphamin in routine clinical practice in adults with acute respiratory viral infection (ARVI). The program included 14,033 patients aged 1897 years with ARVI who received an investigational drug (ID) as monotherapy (93%) or in combination with basic therapy (7%). The frequency of prophylactic prescribing antibacterial drugs was 0.6%. It was shown that fever duration was 2.311.38 days, and the duration of the disease 3.61.52 days. In 99.4% of patients, ID allowed to avoid the development of bacterial complications and prescription of antibacterial drugs. ID showed a stable therapeutic effect in patients who started treatment late, as well as in patients with a moderate course of ARVI, there was no delay in recovery. The results obtained a broad prospect for the use of ID in order to minimize the number of bacterial complications and the frequency of use of antibiotics in ARVI, which may reduce rate of resistance of topical pathogens in the future. |
| first_indexed | 2024-03-13T03:59:55Z |
| format | Article |
| id | doaj.art-58228802d34f458cb57ebccf209a829c |
| institution | Directory Open Access Journal |
| issn | 2075-1753 2542-2170 |
| language | Russian |
| last_indexed | 2024-03-13T03:59:55Z |
| publishDate | 2023-06-01 |
| publisher | ZAO "Consilium Medicum" |
| record_format | Article |
| series | Consilium Medicum |
| spelling | doaj.art-58228802d34f458cb57ebccf209a829c2023-06-21T18:25:47ZrusZAO "Consilium Medicum"Consilium Medicum2075-17532542-21702023-06-0125315716210.26442/20751753.2023.3.2021664677Therapy of acute respiratory viral infections in adults in outpatient clinical practice: new opportunities for the prevention of bacterial complications (Results of the observational program RAPORT)Sergey V. Yakovlev0https://orcid.org/0000-0001-7606-8608Leonid I. Dvoretskiy1https://orcid.org/0000-0003-3186-0102Vladimir A. Petrov2https://orcid.org/0000-0002-8580-933XSechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Obninsk Institute of Atomic Energy – branch of the National Research Nuclear University MEPhIThe frequency of routine prescription of systemic antibacterial drugs in outpatient practice is still unreasonably high despite the desire to reduce them. Under the auspices of the Alliance of Clinical Chemotherapists and Microbiologists, the observational program RAPORT was conducted to assess the therapeutic potential (including bacterial complications preventing) of Raphamin in routine clinical practice in adults with acute respiratory viral infection (ARVI). The program included 14,033 patients aged 1897 years with ARVI who received an investigational drug (ID) as monotherapy (93%) or in combination with basic therapy (7%). The frequency of prophylactic prescribing antibacterial drugs was 0.6%. It was shown that fever duration was 2.311.38 days, and the duration of the disease 3.61.52 days. In 99.4% of patients, ID allowed to avoid the development of bacterial complications and prescription of antibacterial drugs. ID showed a stable therapeutic effect in patients who started treatment late, as well as in patients with a moderate course of ARVI, there was no delay in recovery. The results obtained a broad prospect for the use of ID in order to minimize the number of bacterial complications and the frequency of use of antibiotics in ARVI, which may reduce rate of resistance of topical pathogens in the future.https://consilium.orscience.ru/2075-1753/article/viewFile/473521/125470acute respiratory viral infectionbacterial complications of acute respiratory viral infectionantibacterial effectraphaminobservational program raport |
| spellingShingle | Sergey V. Yakovlev Leonid I. Dvoretskiy Vladimir A. Petrov Therapy of acute respiratory viral infections in adults in outpatient clinical practice: new opportunities for the prevention of bacterial complications (Results of the observational program RAPORT) Consilium Medicum acute respiratory viral infection bacterial complications of acute respiratory viral infection antibacterial effect raphamin observational program raport |
| title | Therapy of acute respiratory viral infections in adults in outpatient clinical practice: new opportunities for the prevention of bacterial complications (Results of the observational program RAPORT) |
| title_full | Therapy of acute respiratory viral infections in adults in outpatient clinical practice: new opportunities for the prevention of bacterial complications (Results of the observational program RAPORT) |
| title_fullStr | Therapy of acute respiratory viral infections in adults in outpatient clinical practice: new opportunities for the prevention of bacterial complications (Results of the observational program RAPORT) |
| title_full_unstemmed | Therapy of acute respiratory viral infections in adults in outpatient clinical practice: new opportunities for the prevention of bacterial complications (Results of the observational program RAPORT) |
| title_short | Therapy of acute respiratory viral infections in adults in outpatient clinical practice: new opportunities for the prevention of bacterial complications (Results of the observational program RAPORT) |
| title_sort | therapy of acute respiratory viral infections in adults in outpatient clinical practice new opportunities for the prevention of bacterial complications results of the observational program raport |
| topic | acute respiratory viral infection bacterial complications of acute respiratory viral infection antibacterial effect raphamin observational program raport |
| url | https://consilium.orscience.ru/2075-1753/article/viewFile/473521/125470 |
| work_keys_str_mv | AT sergeyvyakovlev therapyofacuterespiratoryviralinfectionsinadultsinoutpatientclinicalpracticenewopportunitiesforthepreventionofbacterialcomplicationsresultsoftheobservationalprogramraport AT leonididvoretskiy therapyofacuterespiratoryviralinfectionsinadultsinoutpatientclinicalpracticenewopportunitiesforthepreventionofbacterialcomplicationsresultsoftheobservationalprogramraport AT vladimirapetrov therapyofacuterespiratoryviralinfectionsinadultsinoutpatientclinicalpracticenewopportunitiesforthepreventionofbacterialcomplicationsresultsoftheobservationalprogramraport |