Protein succinylation: regulating metabolism and beyond
Modifications of protein post-translation are critical modulatory processes, which alters target protein biological activity，function and/or location, even involved in pathogenesis of some diseases. So far, there are at least 16 types of post-translation modifications identified, particularly throug...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1336057/full |
| _version_ | 1827357513942564864 |
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| author | Xiaoli Hou Yiqiu Chen Xiao Li Xianliang Gu Weixia Dong Jie Shi Shaoping Ji Shaoping Ji |
| author_facet | Xiaoli Hou Yiqiu Chen Xiao Li Xianliang Gu Weixia Dong Jie Shi Shaoping Ji Shaoping Ji |
| author_sort | Xiaoli Hou |
| collection | DOAJ |
| description | Modifications of protein post-translation are critical modulatory processes, which alters target protein biological activity，function and/or location, even involved in pathogenesis of some diseases. So far, there are at least 16 types of post-translation modifications identified, particularly through recent mass spectrometry analysis. Among them, succinylation (Ksuc) on protein lysine residues causes a variety of biological changes. Succinylation of proteins contributes to many cellular processes such as proliferation, growth, differentiation, metabolism and even tumorigenesis. Mechanically, Succinylation leads to conformation alteration of chromatin or remodeling. As a result, transcription/expression of target genes is changed accordingly. Recent research indicated that succinylation mainly contributes to metabolism modulations, from gene expression of metabolic enzymes to their activity modulation. In this review, we will conclude roles of succinylation in metabolic regulation of glucose, fat, amino acids and related metabolic disease launched by aberrant succinylation. Our goal is to stimulate extra attention to these still not well researched perhaps important succinylation modification on proteins and cell processes. |
| first_indexed | 2024-03-08T05:32:56Z |
| format | Article |
| id | doaj.art-5822c2015d6149919c244f4cadb372e5 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-08T05:32:56Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-5822c2015d6149919c244f4cadb372e52024-02-06T04:22:17ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-02-011110.3389/fnut.2024.13360571336057Protein succinylation: regulating metabolism and beyondXiaoli Hou0Yiqiu Chen1Xiao Li2Xianliang Gu3Weixia Dong4Jie Shi5Shaoping Ji6Shaoping Ji7Department of Basic Medicine, Zhengzhou Shuqing Medical College, Zhengzhou, ChinaDepartment of Basic Medicine, Zhengzhou Shuqing Medical College, Zhengzhou, ChinaDepartment of Basic Medicine, Zhengzhou Shuqing Medical College, Zhengzhou, ChinaDepartment of Basic Medicine, Zhengzhou Shuqing Medical College, Zhengzhou, ChinaDepartment of Basic Medicine, Zhengzhou Shuqing Medical College, Zhengzhou, ChinaZhoukou Vocational and Technical College, Zhoukou, ChinaDepartment of Basic Medicine, Zhengzhou Shuqing Medical College, Zhengzhou, ChinaDepartment of Biochemistry and Molecular Biology, Medical School, Henan University, Kaifeng, ChinaModifications of protein post-translation are critical modulatory processes, which alters target protein biological activity，function and/or location, even involved in pathogenesis of some diseases. So far, there are at least 16 types of post-translation modifications identified, particularly through recent mass spectrometry analysis. Among them, succinylation (Ksuc) on protein lysine residues causes a variety of biological changes. Succinylation of proteins contributes to many cellular processes such as proliferation, growth, differentiation, metabolism and even tumorigenesis. Mechanically, Succinylation leads to conformation alteration of chromatin or remodeling. As a result, transcription/expression of target genes is changed accordingly. Recent research indicated that succinylation mainly contributes to metabolism modulations, from gene expression of metabolic enzymes to their activity modulation. In this review, we will conclude roles of succinylation in metabolic regulation of glucose, fat, amino acids and related metabolic disease launched by aberrant succinylation. Our goal is to stimulate extra attention to these still not well researched perhaps important succinylation modification on proteins and cell processes.https://www.frontiersin.org/articles/10.3389/fnut.2024.1336057/fullpost-translational modificationsuccinylationmetabolismregulationredox |
| spellingShingle | Xiaoli Hou Yiqiu Chen Xiao Li Xianliang Gu Weixia Dong Jie Shi Shaoping Ji Shaoping Ji Protein succinylation: regulating metabolism and beyond Frontiers in Nutrition post-translational modification succinylation metabolism regulation redox |
| title | Protein succinylation: regulating metabolism and beyond |
| title_full | Protein succinylation: regulating metabolism and beyond |
| title_fullStr | Protein succinylation: regulating metabolism and beyond |
| title_full_unstemmed | Protein succinylation: regulating metabolism and beyond |
| title_short | Protein succinylation: regulating metabolism and beyond |
| title_sort | protein succinylation regulating metabolism and beyond |
| topic | post-translational modification succinylation metabolism regulation redox |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1336057/full |
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