Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinoma
The aim of this study was to investigate the factors related to large-volume central cervical lymph node metastasis (LNM) in papillary thyroid carcinoma. A retrospective study of 340 patients with 642 papillary thyroid carcinoma nodules who underwent thyroidectomy in Peking Union Medical College Hos...
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.935559/full |
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| author | Li Tan Jiaqi Ji Jiaqi Ji Gaowa Sharen Yuewu Liu Ke Lv |
| author_facet | Li Tan Jiaqi Ji Jiaqi Ji Gaowa Sharen Yuewu Liu Ke Lv |
| author_sort | Li Tan |
| collection | DOAJ |
| description | The aim of this study was to investigate the factors related to large-volume central cervical lymph node metastasis (LNM) in papillary thyroid carcinoma. A retrospective study of 340 patients with 642 papillary thyroid carcinoma nodules who underwent thyroidectomy in Peking Union Medical College Hospital between 2011 and 2015 was conducted. These nodules were divided into two groups by the number of central cervical lymph node metastases: large‐volume central cervical LNM (>5 metastatic lymph nodes, n = 129) and no central cervical LNM (n = 211). We evaluated the correlations between gender, age, chronic lymphocytic thyroiditis, thyroid ultrasonographic features, and large‐volume central cervical LNM. We found that younger age (≤40 years) (OR = 3.796, 95% CI = 2.842, 5.070), male gender (OR = 4.005, 95% CI = 2.858, 5.61), and ultrasonographic features such as tumor macroaxis size (OR = 2.985, 95% CI = 1.581, 5.633), tumor located in the isthmus (OR = 7.578, 95% CI = 4.863, 11.810), ill-defined margin (OR = 3.008, 95% CI = 1.986, 4.556), microcalcification (OR = 2.155, 95% CI = 1.585, 2.929), and abnormal cervical lymph nodes (OR = 13.753, 95% CI = 9.278, 20.385) were independent risk factors for large-volume central cervical LNM in papillary thyroid carcinoma, while chronic lymphocytic thyroiditis (OR = 0.248, 95% CI = 0.172, 0.358) was a protective factor. Younger age (≤40 years), male sex, and ultrasonographic features such as tumor macroaxis size, tumor located in the isthmus, ill-defined margin, microcalcification, and abnormal cervical lymph nodes were independent risk factors for large-volume central cervical LNM in papillary thyroid carcinoma, while chronic lymphocytic thyroiditis can be considered a protective factor. Our results provide a reference for adjusting clinical treatment approaches. |
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| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T22:34:42Z |
| publishDate | 2022-08-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-5822fbe75bf54dd9b94141a74ebdfdc42022-12-22T03:59:15ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-08-011310.3389/fendo.2022.935559935559Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinomaLi Tan0Jiaqi Ji1Jiaqi Ji2Gaowa Sharen3Yuewu Liu4Ke Lv5Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Ultrasound, Aerospace Center Hospital, Beijing, ChinaDepartment of Health Management, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaThe aim of this study was to investigate the factors related to large-volume central cervical lymph node metastasis (LNM) in papillary thyroid carcinoma. A retrospective study of 340 patients with 642 papillary thyroid carcinoma nodules who underwent thyroidectomy in Peking Union Medical College Hospital between 2011 and 2015 was conducted. These nodules were divided into two groups by the number of central cervical lymph node metastases: large‐volume central cervical LNM (>5 metastatic lymph nodes, n = 129) and no central cervical LNM (n = 211). We evaluated the correlations between gender, age, chronic lymphocytic thyroiditis, thyroid ultrasonographic features, and large‐volume central cervical LNM. We found that younger age (≤40 years) (OR = 3.796, 95% CI = 2.842, 5.070), male gender (OR = 4.005, 95% CI = 2.858, 5.61), and ultrasonographic features such as tumor macroaxis size (OR = 2.985, 95% CI = 1.581, 5.633), tumor located in the isthmus (OR = 7.578, 95% CI = 4.863, 11.810), ill-defined margin (OR = 3.008, 95% CI = 1.986, 4.556), microcalcification (OR = 2.155, 95% CI = 1.585, 2.929), and abnormal cervical lymph nodes (OR = 13.753, 95% CI = 9.278, 20.385) were independent risk factors for large-volume central cervical LNM in papillary thyroid carcinoma, while chronic lymphocytic thyroiditis (OR = 0.248, 95% CI = 0.172, 0.358) was a protective factor. Younger age (≤40 years), male sex, and ultrasonographic features such as tumor macroaxis size, tumor located in the isthmus, ill-defined margin, microcalcification, and abnormal cervical lymph nodes were independent risk factors for large-volume central cervical LNM in papillary thyroid carcinoma, while chronic lymphocytic thyroiditis can be considered a protective factor. Our results provide a reference for adjusting clinical treatment approaches.https://www.frontiersin.org/articles/10.3389/fendo.2022.935559/fullpapillary thyroid carcinomaultrasoundlymph node metastasesthyroid cancercervical lymph node metastases |
| spellingShingle | Li Tan Jiaqi Ji Jiaqi Ji Gaowa Sharen Yuewu Liu Ke Lv Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinoma Frontiers in Endocrinology papillary thyroid carcinoma ultrasound lymph node metastases thyroid cancer cervical lymph node metastases |
| title | Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinoma |
| title_full | Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinoma |
| title_fullStr | Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinoma |
| title_full_unstemmed | Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinoma |
| title_short | Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinoma |
| title_sort | related factor analysis for predicting large volume central cervical lymph node metastasis in papillary thyroid carcinoma |
| topic | papillary thyroid carcinoma ultrasound lymph node metastases thyroid cancer cervical lymph node metastases |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.935559/full |
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