Effect and Regulation of Obesity-Associated Low-Grade Chronic Inflammation in Major Rheumatic Diseases
Current lifestyle and environmental factors contribute to obesity development, leading to low-grade chronic inflammation (LGCI). Apart from obesity, LGCI is also related to rheumatic diseases such as osteoporosis (OP) and osteoarthritis (OA). In these, an excessive accumulation of adipose tissue has...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Rheumato |
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| Online Access: | https://www.mdpi.com/2674-0621/2/4/16 |
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| author | Ana Alonso-Pérez María Guillán-Fresco Miriam López-Fagúndez Andrés Pazos-Pérez Antía Crespo-Golmar María Piñeiro-Ramil Verónica López Alberto Jorge-Mora Rodolfo Gómez |
| author_facet | Ana Alonso-Pérez María Guillán-Fresco Miriam López-Fagúndez Andrés Pazos-Pérez Antía Crespo-Golmar María Piñeiro-Ramil Verónica López Alberto Jorge-Mora Rodolfo Gómez |
| author_sort | Ana Alonso-Pérez |
| collection | DOAJ |
| description | Current lifestyle and environmental factors contribute to obesity development, leading to low-grade chronic inflammation (LGCI). Apart from obesity, LGCI is also related to rheumatic diseases such as osteoporosis (OP) and osteoarthritis (OA). In these, an excessive accumulation of adipose tissue has been linked to an excessive production of proinflammatory factors, such as adipokines. This work’s aim is to stablish the effect of obesity-associated LGCI in major rheumatic diseases and to determine optimal strategies to reduce it. Obesity is a risk factor for developing OA, where a systemic LGCI state has been found. Concretely, obesity-associated LGCI has been described as an OA instauration and progression promoter. To avoid this, several therapeutical approaches (diet control, physical exercise, or nutraceuticals) have been tested. OP is another major rheumatic disease where a basal LGCI has been described, being worsened by obesity. As in OA, diet management and supplementation with vitamin D or probiotics have been proposed as approaches to treat obesity-associated LGCI in this pathology. Currently, the increase in the prevalence of rheumatic diseases is unstoppable. Nonetheless, obesity is a risk factor that can be controlled. Thus, the study of new interventions to control the impact of obesity-associated LGCI is a challenge for the management of patients with rheumatic diseases. |
| first_indexed | 2024-03-11T08:11:46Z |
| format | Article |
| id | doaj.art-5824b6639a51494b948bd9e4467aa1f5 |
| institution | Directory Open Access Journal |
| issn | 2674-0621 |
| language | English |
| last_indexed | 2024-03-11T08:11:46Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Rheumato |
| spelling | doaj.art-5824b6639a51494b948bd9e4467aa1f52023-11-16T23:04:51ZengMDPI AGRheumato2674-06212022-11-012411412510.3390/rheumato2040016Effect and Regulation of Obesity-Associated Low-Grade Chronic Inflammation in Major Rheumatic DiseasesAna Alonso-Pérez0María Guillán-Fresco1Miriam López-Fagúndez2Andrés Pazos-Pérez3Antía Crespo-Golmar4María Piñeiro-Ramil5Verónica López6Alberto Jorge-Mora7Rodolfo Gómez8Musculoskeletal Pathology Group, Laboratory 18, Institute IDIS, Santiago University Clinical Hospital, 15706 Santiago de Compostela, SpainMusculoskeletal Pathology Group, Laboratory 18, Institute IDIS, Santiago University Clinical Hospital, 15706 Santiago de Compostela, SpainMusculoskeletal Pathology Group, Laboratory 18, Institute IDIS, Santiago University Clinical Hospital, 15706 Santiago de Compostela, SpainMusculoskeletal Pathology Group, Laboratory 18, Institute IDIS, Santiago University Clinical Hospital, 15706 Santiago de Compostela, SpainMusculoskeletal Pathology Group, Laboratory 18, Institute IDIS, Santiago University Clinical Hospital, 15706 Santiago de Compostela, SpainMusculoskeletal Pathology Group, Laboratory 18, Institute IDIS, Santiago University Clinical Hospital, 15706 Santiago de Compostela, SpainMusculoskeletal Pathology Group, Laboratory 18, Institute IDIS, Santiago University Clinical Hospital, 15706 Santiago de Compostela, SpainMusculoskeletal Pathology Group, Laboratory 18, Institute IDIS, Santiago University Clinical Hospital, 15706 Santiago de Compostela, SpainMusculoskeletal Pathology Group, Laboratory 18, Institute IDIS, Santiago University Clinical Hospital, 15706 Santiago de Compostela, SpainCurrent lifestyle and environmental factors contribute to obesity development, leading to low-grade chronic inflammation (LGCI). Apart from obesity, LGCI is also related to rheumatic diseases such as osteoporosis (OP) and osteoarthritis (OA). In these, an excessive accumulation of adipose tissue has been linked to an excessive production of proinflammatory factors, such as adipokines. This work’s aim is to stablish the effect of obesity-associated LGCI in major rheumatic diseases and to determine optimal strategies to reduce it. Obesity is a risk factor for developing OA, where a systemic LGCI state has been found. Concretely, obesity-associated LGCI has been described as an OA instauration and progression promoter. To avoid this, several therapeutical approaches (diet control, physical exercise, or nutraceuticals) have been tested. OP is another major rheumatic disease where a basal LGCI has been described, being worsened by obesity. As in OA, diet management and supplementation with vitamin D or probiotics have been proposed as approaches to treat obesity-associated LGCI in this pathology. Currently, the increase in the prevalence of rheumatic diseases is unstoppable. Nonetheless, obesity is a risk factor that can be controlled. Thus, the study of new interventions to control the impact of obesity-associated LGCI is a challenge for the management of patients with rheumatic diseases.https://www.mdpi.com/2674-0621/2/4/16obesitychronic inflammationosteoarthritisosteoporosis |
| spellingShingle | Ana Alonso-Pérez María Guillán-Fresco Miriam López-Fagúndez Andrés Pazos-Pérez Antía Crespo-Golmar María Piñeiro-Ramil Verónica López Alberto Jorge-Mora Rodolfo Gómez Effect and Regulation of Obesity-Associated Low-Grade Chronic Inflammation in Major Rheumatic Diseases Rheumato obesity chronic inflammation osteoarthritis osteoporosis |
| title | Effect and Regulation of Obesity-Associated Low-Grade Chronic Inflammation in Major Rheumatic Diseases |
| title_full | Effect and Regulation of Obesity-Associated Low-Grade Chronic Inflammation in Major Rheumatic Diseases |
| title_fullStr | Effect and Regulation of Obesity-Associated Low-Grade Chronic Inflammation in Major Rheumatic Diseases |
| title_full_unstemmed | Effect and Regulation of Obesity-Associated Low-Grade Chronic Inflammation in Major Rheumatic Diseases |
| title_short | Effect and Regulation of Obesity-Associated Low-Grade Chronic Inflammation in Major Rheumatic Diseases |
| title_sort | effect and regulation of obesity associated low grade chronic inflammation in major rheumatic diseases |
| topic | obesity chronic inflammation osteoarthritis osteoporosis |
| url | https://www.mdpi.com/2674-0621/2/4/16 |
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