Correlation of Plasma Lipid Profile with Salivary Oxidative Stress Markers in Type Ii Diabetes Mellitus Patients
Introduction: Diabetes is known to be associated with greater production of reactive oxygen species (ROS) like malondialdehyde (MDA) and decreased antioxidants like total thiols and its estimation in plasma is used in monitoring the redox status. The aim of this study was to analyse the associat...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-06-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4451/8233_CE[Ra1]_F(DK)_PF1(PAK)_PFA(AK)_PF2(AGAK)_PF2(PN).pdf |
| Summary: | Introduction: Diabetes is known to be associated with greater
production of reactive oxygen species (ROS) like malondialdehyde
(MDA) and decreased antioxidants like total thiols and its
estimation in plasma is used in monitoring the redox status. The
aim of this study was to analyse the association between plasma
lipid profile parameters like HDL and LDL with salivary MDA and
thiols in diabetic patients.
Materials and Methods: Sixty subjects between the age group
35- 70 years who were diagnosed with type II diabetes mellitus
based on fasting blood glucose and glycated haemoglobin levels
who attended the dental OPD at Kasturba Medical College and
Hospital, Manipal consented to participate in this study. Plasma
glucose, HDL and LDL were estimated in Cobas autoanalyser by
hexokinase method, homogenous enzymatic colorimetric assay
and Friedwald’s formula respectively. Assessment of glycated
hemoglobin was by ion exchange chromatography, MDA by
thiobarbituric acid as a substrate and thiols by Ellmann’s manual
method in plasma and saliva.
Results: The association of plasma LDL with salivary MDA was
found to be positive and significant and that with salivary thiols
was negative and significant. Also, the association of plasma
HDL with salivary MDA was found to be negative and significant
and that with salivary thiols was positive and significant.
Conclusion: Results indicate the potential of saliva as a tool to
monitor prognosis of diabetes. |
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| ISSN: | 2249-782X 0973-709X |